Australia ‘We can treat it': Mortality rate of rare condition linked to AstraZeneca shot plunges

14:41  07 june  2021
14:41  07 june  2021 Source:   brisbanetimes.com.au

A guide on how to get your vaccine in Victoria

  A guide on how to get your vaccine in Victoria A short guide on how to work out what vaccine you're eligible to receive, how to book an appointment, and where to go for a walk-in vaccination. How do I book in for a vaccine? The state government set up a dedicated vaccination hotline on Friday morning after the coronavirus hotline crashed for several hours on Thursday amid overwhelming demand following its decision to offer vaccinations to those aged over 40. The best way to to book in for your Pfizer or AstraZeneca shot is to call the Victorian government's new COVID vaccination hotline on 1800 571 121.

Video: SA Health confirms blood clot case linked to AstraZeneca jab (Sky News Australia)

a man smiling for the camera: Professor Huyen Tran, he is leading the care for people who have suffered blood clots after having a dose of AstraZeneca's vaccine. 7 June 2021. The Age news. Photo: Eddie Jim. © Eddie Jim Professor Huyen Tran, he is leading the care for people who have suffered blood clots after having a dose of AstraZeneca's vaccine. 7 June 2021. The Age news. Photo: Eddie Jim.

Doctors are now confident they can detect and treat the rare blood clotting syndrome associated with AstraZeneca's vaccine, with just one death recorded so far.

When the syndrome, known as thrombosis with thrombocytopenia (TTS), was first identified one in four people with it died.

But the fatality rate has been dropping in Europe, where it was first identified. As of last Thursday, Australia had recorded 31 confirmed and 10 probable cases.

Japan donates more than 1 million AstraZeneca jabs to Taiwan

  Japan donates more than 1 million AstraZeneca jabs to Taiwan Tokyo is donating more than one million doses of the AstraZeneca coronavirus vaccines to Taiwan, Japan's foreign minister announced Friday, as Taipei struggles to secure jabs, accusing China of interference. © Philip FONG Japan has secured enough AstraZeneca doses for 60 million people but is not administering it, as concerns linger about rare blood clots The move is likely to stir controversy with Beijing, which views democratic and self-ruled Taiwan as its own territory and works to keep the island diplomatically isolated.

Of those cases, 23 are out of hospital and recovering, four require ongoing care and 13 remain in hospital.

Two trends are emerging, experts say: doctors are detecting more cases due to better screening, which shows the syndrome is more common but less deadly than first thought, and treatments have improved dramatically.

"We can recognise it, we can diagnose it, and we can treat it," said Huyen Tran, head of the Alfred hospital's thrombosis and haemostasis unit and a member of the Thrombosis and Haemostasis Society of Australia and New Zealand's working group investigating the syndrome

Liam Mannix's Examine newsletter explains and analyses science with a rigorous focus on the evidence. Sign up to get it each week.

Professor Tran has been personally involved in the care of nearly every patient with TTS in Victoria.

Thailand starts long-awaited COVID vaccination campaign

  Thailand starts long-awaited COVID vaccination campaign Thailand rolls out locally produced AstraZeneca jabs as it begins a much-anticipated mass inoculation campaign.The campaign’s launch on Monday came as Thailand battles its third and worst wave of the coronavirus pandemic.

He said it was always going to be the case that newly discovered conditions had higher mortality rates at first, but that the true mortality rate would end up being much lower.

The syndrome is extremely unusual, doctors say, as it causes both blood clots and low levels of platelets in the bloodstream.

Australia's Technical Advisory Group on Immunisation (ATAGI) advised in April that Pfizer's vaccine should be "preferred" for people under 50 due to evidence the risk of the syndrome was higher for younger people.

At the time, the advisory group estimated it occurred at a rate of between four and six cases per million, with a fatality rate of 25 per cent (meaning one in four people with the syndrome were expected to die), based on overseas data.

Europe has now doubled its estimates to around 20 cases per million doses for those under 50; for over 50s, the rate is closer to 10 in a million.

Delta force

  Delta force Good morning, early birds. Victorian officials and experts have expressed concern about the highly-infectious Delta variant, and 3-year-old Christmas Island detainee Tharnicaa Murugappan has been medically evacuated to Perth with a suspected blood infection. It's the news you need to know, with Chris Woods.Eighteen new exposure sites identified yesterday span cafes, chemists and a number 19 tram, and date from May 30-June 6, across Campbellfield, Coburg, Coburg North, Flemington, Glenroy, Maribyrnong, Melbourne, Mickleham, Port Melbourne, Southbank, South Melbourne, Strathmore, and Yarraville.

Australia's fatality rate presently sits between 2.4 and 3.2 per cent. However, Australia has done fewer vaccinations than other countries and has not been giving AstraZeneca to people under 50.

Britain's fatality rate sits at 18 per cent.

"When you look at the data from overseas, that mortality rate is coming down - most are coming down to 10 per cent, and I presume it will come down further again," said Professor Paul Monagle, who is studying the syndrome at the Murdoch Children's Research Institute.

"It's not the uniformly catastrophic disease that was originally presented."

To treat the rare syndrome, Australian doctors are using injections of antibodies taken from the blood of donors. This treatment, known as intravenous immunoglobulin, has been shown to be effective in similar autoimmune blood clotting disorders.

ATAGI's decision to prefer Pfizer over AstraZeneca for people under 50 was made after balancing risk - including the 25 per cent fatality rate - and reward.

Experts said a lower fatality rate and Melbourne's current COVID-19 outbreak did change that risk-benefit calculation, but not enough to alter the earlier recommendation.

Blood clots linked to Covid-19 vaccines are still extremely rare

  Blood clots linked to Covid-19 vaccines are still extremely rare Medical experts say blood clots linked to COVID-19 vaccines remain extremely rare and Australians should continue to roll up their sleeves for the jab. The Therapeutic Goods Administration reported a 52-year-old NSW woman died from a blood clot in the brain - the second person to do so out of 3.6 million doses of the AstraZeneca vaccine delivered.Of the 48 confirmed and probable cases of people who have developed clots after receiving the vaccine, 31 have been discharged from hospital and are recovering.Fifteen remain in hospital.

"Even if mortality drops, as is likely, it does appear to be a more severe disease in the younger population with worse non-fatal disease course and outcomes than in the over 50s," said Professor Jim Buttery, head of epidemiology at the Victorian immunisation safety service.

ATAGI declined to comment directly on whether the risk-benefit calculus was changing.

It remains unclear just what causes the syndrome.

Early attention focused on the possibility AstraZeneca's vaccine was causing the immune system to make an antibody against a protein released by blood platelets. The antibody then binds to the platelets, activating them and causing blood clots to form.

Late last month German scientists uploaded a paper - not yet peer reviewed - suggesting AstraZeneca's vaccine may cause immunised cells to release proteins in the blood, which are then bound by antibodies, causing blood clots.

"There is a lot more work to be done yet before we get to the bottom of it," said Professor Monagle.

AstraZeneca and Pfizer COVID vaccine shots lead to missed work days, survey reveals .
It's normal to have some side effects after the COVID vaccine, but new research shows people report more symptoms after the first AstraZeneca vaccine and second Pfizer dose. Here's what to expect."I get my flu shot every year and don't normally get any reaction at all," Mr Cronin said.

usr: 0
This is interesting!