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Entertainment COVID-19: What is known from Paxlovid, the treatment of Pfizer that will be available in France late January

18:30  17 january  2022
18:30  17 january  2022 Source:   francetvinfo.fr

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The treatment of the American laboratory must be taken twice a day for five days, from the diagnosis and in the five days after the appearance of symptoms.

  Covid-19 : ce que l'on sait du Paxlovid, le traitement de Pfizer qui sera disponible en France fin janvier © Provided by FranceInfo

A new weapon against the pandemic. Paxlovid antiviral treatment, created by the American laboratory Pfizer , must soon arrive in France. These tablets can drastically reduce the risk of hospitalization and deaths for people with Covid-19 . Here is what we know about this new promising treatment.

An antiviral treatment created specifically against SAR-COV-2

Paxlovid is an antiviral: it acts by reducing the ability of the virus to replicate, thus braking the disease. It represents a complement to vaccines to protect from COVID-19. Unlike its competitors, the treatment of Pfizer has not been rehabilitated from another drug, but specifically developed against SARS-COV-2. This is a new molecule called Nirmatrelvir (or PF-07321332).

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The treatment is administered in the form of two tablets of Nirmatrelvir and an tablet of ritonavir, an antiretroviral already used against HIV. Easy to administer, it must be taken twice a day for five days, from the diagnosis and within five days after the appearance of symptoms.

89% efficiency against hospitalizations and deaths

in early November, Pfizer announced the first results (very positive) of its anti-covid medicine. Among adults at high risk of developing a serious form of the disease, PAXLOVID has been effective at 89% to prevent hospitalizations and deaths, according to intermediate results of clinical trials.

The first results of Pfizer are based on clinical trials carried out on a few more than 200 adults who have contracted CVIV-19 and at risk of developing a serious form.

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Contraindications and side effects

The treatment of Pfizer is not recommended during pregnancy and in persons likely to fall pregnant, specified the European Medicine Agency in a statement, December 16, 2021. Breastfeeding should also be interrupted when taking treatment. Finally, the most common side effects are a disturbance of taste, diarrhea and nausea.

A treatment available in France End of January

Paxlovid should soon arrive in French pharmacies. "We are waiting for two" medicine "deployments by the end of this month," said Olivier Véran , January 10 in the Senate. The Minister of Health then referred to Paxlovid, but also the treatment developed by GSK, Sotrovimab, administered to the hospital.

In December, the European Medicine Agency had approved the use in case of emergency in the European Union of Pfizer Treatment. And this, even if, for the time being, these tablets have not yet received a full marketing authorization. The final opinion of the European regulator is expected in the coming weeks.

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An order of 20 million treatments in the United States

the United States double the setting. In early January, the US government announced that it would double, to 20 million versus 10 million previously, its order of PaxLovid. "We have already spent the most important order in the world, and now I double it," said Joe Biden. The US executive had disbursed $ 5.29 billion for its initial order of 10 million treatments. Some 250,000 treatments should be available in the country as early as January, according to Joe Biden.

Tablets partly manufactured in France

Paxlovid will partly be made in France, with a manufacture planned in Mourenx, in the Pyrénées-Atlantiques. "We announced a large investment plan in France, 520 million euros over five years," said Managing Director of Pfizer, Albert Bourla, on BFMTV , Monday, January 17th. "Most of this investment will be allocated to a partnership with the NOVASEP company in Mourenx to produce the active pharmaceutical ingredient of this medicine for the whole world."

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