Money: Could personalised medicine save Australia’s health system ‘billlions’? - PressFrom - Australia

MoneyCould personalised medicine save Australia’s health system ‘billlions’?

07:30  11 january  2019
07:30  11 january  2019 Source:

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The concepts of personalised medicine can be applied to new and transformative approaches to health care. Personalised health care is based on the dynamics of systems biology and uses predictive tools to evaluate health risks and to design personalised health plans to help patients

Health care in Australia is delivered as a mixed system : universal health care (public) and private providers (insurance). Most health care is provided publicly

Could personalised medicine save Australia’s health system ‘billlions’?© Stockhead Australia Could personalised medicine save Australia’s health system ‘billlions’?

It seems like a logical idea — tailoring medical practices, treatments and care to the specific individual rather than applying an accepted broad brush strategy that does not take into account a patient’s unique circumstances and genetic makeup.

That’s the idea behind personalised medicine, a theory that has been around since Hippocrates. But while his Hippocratic Oath remains in use today, personalised medicine is scarce.

Fundamentally, it is about mapping a person’s DNA and then analysing it before treatment, with the DNA outlining whether a treatment will be effective before it is administered.

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Personalized medicine is an extension of traditional approaches to understanding and treating illness. Since the beginning of the study of medicine Genetic profiles can help physicians to better discern subgroups of patients with various forms of cancer in addition to other complex diseases, helping to

Personalised medicine is a move away from a ‘one size fits all’ approach to the treatment and care of patients with a particular condition, to one NHS England is beginning a discussion about what we mean by personalised medicine , now and in the future, and the approach we will take, working with

Dr Vijay Suppiah, a scientist at UniSA, wants Australia to embrace pharmacogenetic testing (PGx) to save billions “wasted each year through unsafe and ineffective drug prescriptions”.

“Most people expect that when they get a prescription filled from a pharmacy, it will be effective and have minimal side effects,” he said. “Unfortunately that only happens in up to 60 per cent of cases.

“People don’t realise their genetic makeup plays a large role in whether a specific drug will work or not or even have adverse side effects.”

He goes on to say that Australia is trailing investment into PGx testing compared with the US and Europe, with Deloitte suggesting that PGx testing would deliver economic benefits to Australia in the order of $12 billion over 15 years if adopted nationally.

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“If community pharmacists had access to their clients’ PGx test results in their database, they could tell straight away if a particular drug or dose is going to work optimally for that client based on that individual’s genetic makeup.”

And while we’ll have to wait and see whether increased calls for personalised medicine garner widespread support in Australia, a number of small cap ASX companies are embracing it to improve patient outcomes and separate themselves from the swath of biotechs on the market.

Scott Power, Morgans senior analyst, says there is plenty of talk about the subject.

“It’s the way things are heading,” he tells Stockhead. “Personalised medicine is all about really trying to target the drug or treatment to fit the person and fit the condition they have.

He points to Kazia Therapeutics (ASX:KZA) as an example. It is attempting to treat glioblastoma, a form of brain cancer.

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A health system , also sometimes referred to as health care system or as healthcare system , is the organization of people, institutions

Temozolomide is the drug most often used to treat glioblastoma, but only 35 per cent of patients respond to it. It is developing GDC-0084 for the 65 per cent of patients who will not respond to existing treatment.

“It makes sense because not only is it much more appropriate for the patient because you’re not giving drugs to patients that have a minimal chance of working, but it also makes economic sense as well, because if you can target the drug you have a much higher chance of getting it to market,” Mr Power says.

It is not the only one dabbling in personalised medicine. Invitrocue (ASX:IVQ) owns 3D-based diagnostic technology that helps clinicians work out the best drugs to administer more quickly.

Singapore-based Invitrocue’s flagship product is Onco-PDO, as in oncology patient-derived organoid. It uses 3D cultures to grow a patient’s own cancer cells on scaffolds and then test them in view of the best medicine to use.

Stem cell biotech Regeneus (ASX:RGS) is testing its cancer therapy RGSH4K, which is a vaccine manufactured from a patient’s own cancer cells.

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Precision, or personalized , medicine is a new and better approach to health care based on each Increasingly it is allowing health care providers to: shift the emphasis in medicine from reaction to Systems genetics is a comprehensive approach to studying and understanding this biological

The Personalized Medicine Coalition (PMC), representing innovators, scientists, patients, providers and payers, promotes the understanding and adoption of Some 20 institutions representing different sectors of the health system launched PMC in 2004 to improve upon medical paradigms that base

Such vaccines are called autologous vaccines, and offer patients more specific, personalised treatment with the right mix of tumour associated antigens (TAAs) for the body to recognise and attack.

Back in April last year, Prescient Therapeutics (ASX:PTX) treated 28 women who had a kind of breast cancer that has little or no HER2 (human epidermal growth factor receptor 2) protein with its PTX-200 drug. They claim it cured two women completely.

Mr Power says companies such as Kazia, Invitrocue, Regeneus and Prescient may find success tailoring their clinical programs to very specific indications. And though its venous leg ulcer trial failed, Mr Power had plenty of praise for Factor Therapeutics (ASX:FTT) for adapting its trial to the indication it thought would work, rather than the broad see-what-sticks strategy that many biotechs take.

“What they tried to do was the right approach. They targeted a small population base that they thought they had the best chance of succeeding it,” he says. “Now, it didn’t work, but designing trials around the target that will give you the best possible outcome is the right approach.

“I think we will start to see better-designed, more sophisticated trials, with better analysis work being done beforehand, targeting and personalising their treatment.

“Personalised medicine has been around for a while and is a concept that makes a lot of sense.”

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