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MoneyCould personalised medicine save Australia’s health system ‘billlions’?

07:30  11 january  2019
07:30  11 january  2019 Source:   stockhead.com.au

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Health care in Australia is delivered as a mixed system : universal health care (public) and private providers (insurance). The majority of Australia ' s health care is provided publicly

The remaining folks get reasonable benefit. So, we could effectively reduce our use of this treatment by 50% and actually save more lives, because we don’t cause With the right decision support system , this figure could be produced automatically in a well-designed EMR system across a vareity of risks.

Could personalised medicine save Australia’s health system ‘billlions’?© Stockhead Australia Could personalised medicine save Australia’s health system ‘billlions’?

It seems like a logical idea — tailoring medical practices, treatments and care to the specific individual rather than applying an accepted broad brush strategy that does not take into account a patient’s unique circumstances and genetic makeup.

That’s the idea behind personalised medicine, a theory that has been around since Hippocrates. But while his Hippocratic Oath remains in use today, personalised medicine is scarce.

Fundamentally, it is about mapping a person’s DNA and then analysing it before treatment, with the DNA outlining whether a treatment will be effective before it is administered.

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The Australian healthcare system has two main components; the public health system which is administered by the Australian Government This can be done by selecting an Australian Health Plan that covers in-hospital (in-patient) costs. Reciprocal Health Care Agreements with Australia .

A health system , also sometimes referred to as health care system or as healthcare system , is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.

Dr Vijay Suppiah, a scientist at UniSA, wants Australia to embrace pharmacogenetic testing (PGx) to save billions “wasted each year through unsafe and ineffective drug prescriptions”.

“Most people expect that when they get a prescription filled from a pharmacy, it will be effective and have minimal side effects,” he said. “Unfortunately that only happens in up to 60 per cent of cases.

“People don’t realise their genetic makeup plays a large role in whether a specific drug will work or not or even have adverse side effects.”

He goes on to say that Australia is trailing investment into PGx testing compared with the US and Europe, with Deloitte suggesting that PGx testing would deliver economic benefits to Australia in the order of $12 billion over 15 years if adopted nationally.

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My Health Record is an online summary of your key health information. Give your doctors access to your important health information like medicines , allergies and test results, which can mean safer and more efficient care for you and your family.

The Australian healthcare system provides a wide range of services, from population health and prevention through to general practice and community health ; emergency health services and hospital care; and rehabilitation and palliative care. General practitioners (GPs) and emergency departments

“If community pharmacists had access to their clients’ PGx test results in their database, they could tell straight away if a particular drug or dose is going to work optimally for that client based on that individual’s genetic makeup.”

And while we’ll have to wait and see whether increased calls for personalised medicine garner widespread support in Australia, a number of small cap ASX companies are embracing it to improve patient outcomes and separate themselves from the swath of biotechs on the market.

Scott Power, Morgans senior analyst, says there is plenty of talk about the subject.

“It’s the way things are heading,” he tells Stockhead. “Personalised medicine is all about really trying to target the drug or treatment to fit the person and fit the condition they have.

He points to Kazia Therapeutics (ASX:KZA) as an example. It is attempting to treat glioblastoma, a form of brain cancer.

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The concepts of personalised medicine can be applied to new and transformative approaches to health care. Reimbursement policies will have to be redefined to fit the changes that personalised medicine will bring to the healthcare system .

UMC Health System . Medical Services. Next. Back. Meet Rakhshanda L. Rahman, M.D. Personalized Care. Questions to Ask Your Doctor. Pediatric Oncology & Hematology.

Temozolomide is the drug most often used to treat glioblastoma, but only 35 per cent of patients respond to it. It is developing GDC-0084 for the 65 per cent of patients who will not respond to existing treatment.

“It makes sense because not only is it much more appropriate for the patient because you’re not giving drugs to patients that have a minimal chance of working, but it also makes economic sense as well, because if you can target the drug you have a much higher chance of getting it to market,” Mr Power says.

It is not the only one dabbling in personalised medicine. Invitrocue (ASX:IVQ) owns 3D-based diagnostic technology that helps clinicians work out the best drugs to administer more quickly.

Singapore-based Invitrocue’s flagship product is Onco-PDO, as in oncology patient-derived organoid. It uses 3D cultures to grow a patient’s own cancer cells on scaffolds and then test them in view of the best medicine to use.

Stem cell biotech Regeneus (ASX:RGS) is testing its cancer therapy RGSH4K, which is a vaccine manufactured from a patient’s own cancer cells.

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Personalized Medicine that is customized to treat the health & wellness of each individual' s unique genetic DNA. American Biohacker is a no-holds-barred, no-punches-pulled look into our broken medical system and how most Americans are following the wrong advice.

The Personalized Medicine Coalition (PMC), representing innovators, scientists, patients, providers and payers, promotes the understanding and adoption of personalized medicine concepts, services, and products to benefit patients and the health system . Believing that paradigm shifts, especially in

Such vaccines are called autologous vaccines, and offer patients more specific, personalised treatment with the right mix of tumour associated antigens (TAAs) for the body to recognise and attack.

Back in April last year, Prescient Therapeutics (ASX:PTX) treated 28 women who had a kind of breast cancer that has little or no HER2 (human epidermal growth factor receptor 2) protein with its PTX-200 drug. They claim it cured two women completely.

Mr Power says companies such as Kazia, Invitrocue, Regeneus and Prescient may find success tailoring their clinical programs to very specific indications. And though its venous leg ulcer trial failed, Mr Power had plenty of praise for Factor Therapeutics (ASX:FTT) for adapting its trial to the indication it thought would work, rather than the broad see-what-sticks strategy that many biotechs take.

“What they tried to do was the right approach. They targeted a small population base that they thought they had the best chance of succeeding it,” he says. “Now, it didn’t work, but designing trials around the target that will give you the best possible outcome is the right approach.

“I think we will start to see better-designed, more sophisticated trials, with better analysis work being done beforehand, targeting and personalising their treatment.

“Personalised medicine has been around for a while and is a concept that makes a lot of sense.”

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