Tech & Science brain: Alzheimer, epilepsy ... Can we regenerate lost neurons?
NASSER HUSSAIN: Brilliance and brain fades made Moeen Ali so watchable
NASSER HUSSAIN: Moeen Ali's Test career encapsulated why we watch cricket. There was brilliance but there were also, as Moeen would say himself, those brain fade moments . It is what makes sport, and Moeen Ali in particular, so watchable.Moeen, who confirmed his Test retirement on Monday, ended up with almost 3,000 runs and nearly 200 wickets and that is the record of a genuine Test all-rounder. But he was certainly a man of extremes.
According to a recent study, scientists have found a way to regenerate neurons lost by the brain because of epilepsy. A cell reprogramming technique that paves the way for therapeutic perspectives for other neurological diseases such as Alzheimer or Parkinson.
This is a new hope for all patients with neurodegenerative diseases. According to a new study published in the Cell Stem Cell journal on September 29, researchers managed to "transform non-neuronal cells present in the brain into new inhibitory neurons which make it possible to halve the chronic epileptic activity". This is explained by the Inserm Communiqué, whose researchers have worked on the study alongside CNRS researchers, Claude Bernard Lyon 1 at the Institute Cell Straße and Brain and in collaboration with The King's College of London. Starting from the observation that the brain was devoid of regenerative capacities for to replace damaged or lost neurons , they used the technique of direct cell reprogramming in order to "reprogram" the identity of certain non-neuronal cells present within the very non-neuronal cells. sick brain to turn them into neurons. Result, they have reached transforming glial cells from the brain into new neurons in mice suffering from mesio-temporal epilepsy, the most frequent pharmaco-resistant epilepsy form in humans.
Milder COVID-19 infection could still leave brain with lasting impact: UK study
Mild cases of COVID-19 could also leave a lasting impact on the human brain, according to a recent study. EARLY ADULTHOOD DEPRESSION INCREASES DEMENTIA RISK STUDY FINDS In August, researchers from England's University of Oxford and the Imperial College of London wrote that brain imaging from the UK Biobank – including the data from more than 40,000 people in the United Kingdom, dating back to 2014 – showed differences in gray matter thickness between those who had been infected with COVID-19 and those who had not.
reprogram the glial cells to make neurons
in practice, the researchers left the observation only during neuronal death, as observed in the case of the mesio-temporal epilepsy, "the glial cells present in the direct environment Damaged neurons react by multiplying without this glial response resolves the problem ". As part of the study, the researchers had the idea of taking advantage of this proliferation and use these supernumerary glial cells.
The Inserm specifies that at first, they have "identified genes for transforming these glial cells into inhibitory neurons", whose loss plays a key role in the occurrence of epileptic seizures, in order to " restore balance neuronal activities that has been impacted ". The researchers have thus chosen genes known to be involved in the genesis of these inhibitory neurons during the development and then, by "forcing the expression of these genes, they were able to reprogram the identity of the glial cells to make neurons, so-called 'induced neurons, whose properties are comparable to those missing in the disease. Twice Twice Crises Epileptics In Mice
Bat bites and rabies: What to know
An Illinois man died this month after being bitten by a bat in the state's first human case of rabies since 1954. The Illinois Department of Public Health (IDPH) said in a statement that the Lake County man, in his 80s, declined to start post-exposure rabies treatment after the August incident. ILLINOIS MAN DIES OF RABIES IN STATE'S FIRST HUMAN CASE SINCE THE 1950S A month later, the man started experiencing symptoms of rabies and subsequently died. The bat tested positive for rabies and a bat colony was later found in the man's home. The U.S.
The researchers then used stereotaxic surgery to directly insert the genes into the mouse brain at the epileptic focus using disabled viral vectors inducing the reprogramming of glial cells. Result, "
in a few weeks, the vast majority of these glial cells received the genes had turned into new neurons." These new neurons created had " molecular characteristics similar to those of the neurons that had been lost because of the disease". They thus inhibited the neighboring neurons that were responsible for epileptic seizures. The mice saw their epileptic episodes divided by two.This is an
new therapeutic track to fight against epilepsy. "These results thus reveal the therapeutic potential of this cell reprogramming strategy to combat pathology such as measio-temporal epilepsy. A boon in the precise case of this disease while 30% of patients who are reached are refractory Pharmacological treatments, "explains Christophe Heinrich, the main author of the study. Cellular reprogramming useful for other diseases?This work makes it possible to consider therapeutic perspectives in humans on this technique against mesio-temporal epilepsy, but also against other neurological diseases such as Alzheimer or Parkinson.
Regenerate the neurons destroyed following strokes, in some forms of epilepsies or in Parkinson's disease would also become possible.
Tom Parker breaks down as he talks about brain tumour in documentary .
The Wanted singer Tom Parker bared his soul on Sunday night in his Channel 4 documentary Inside My Head. And the 33-year-old, who is battling a brain tumour, was seen breaking down as he detailed his illness, before performing at the Royal Albert Hall with his band.The pop star was documenting the last few months, which has seen him undergo treatment for cancer. © Provided by Daily Mail ( He told cameras how he has suffered from short-term memory loss, how he spent nearly three months in bed solidly, and how he has tried to deal with his prognosis.