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Tech & Science newly discovered cancer weak point "Could revolutionize precision medicine"

20:40  08 december  2022
20:40  08 december  2022 Source:   fr.de

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Krebszellen im menschlichen Körper. (Symbolbild) © Imago/Westend61 Cancer cells in the human body. (Symbol image) newly discovered cancer weakness "Could revolutionize precision medicine"

researchers develop an algorithm that discovers a cancer weak point. The new method works in the laboratory.

Michigan - around 500,000 people in Germany develop cancer in Germany, according to estimates, around one million people in Europe are said to be undetected. The disease is one of the most common causes of death worldwide. Researchers all over the world work on opportunities to recognize, combat or at least contain different types of cancer as early as possible. Researchers from the University of Michigan have now succeeded in a promising discovery.

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The researchers from the Rogel Cancer Center have developed a computer platform that is intended to enable the development of personalized therapies in ovarian cancer. The research team around Deepak Nagrath then used the new development in mice - with success. "This could revolutionize precision medicine," explains Deepak Nagrath from the University of Michigan, an author of the study published in the Nature Metabolism journal.

Cancer Research: Investigations in their research in their research, the scientists around Nagrath focused on ovarian cancer, a disease in which mutations often occur. These provide the cells a growth advantage that contributes to the aggressiveness of the disease. In addition to the mutations, deletions also occur regularly. "If a gene is deleted, the metabolic genes that enable the growth of cancer cells will also be deleted," explains Nagrath in a statement from his university. "The theory states that vulnerabilities arise in the metabolism of cancer cells due to specific genetic changes."

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based on this theory, the team around Nagrath examined the relationship between the metabolism and these genes. According to this, cancer cells change their own metabolism when their metabolic genes are deleted. This is how you compensate for the loss, tumor formation and cancer growth can be continued aggressively. With complex metabolic modeling, machine learning and algorithms, the researchers found that a reaction of the ovarian cancer enzyme MTHFD2 is a weak point.

researchers discover vulnerability for ovarian cancer

in ovarian cancer cells in which the gene UQCR11 was deleted, there is a critical imbalance of the NAD+metabolic product. In response to the imbalance, the enzyme MTHFD2 changes its own function and forms NAD+cells. A weak point arises that researchers want to use to selectively kill cancer cells. “Most cancer medications affect normal tissues and cells. However, our strategy makes it possible to specifically address cancer cells, ”emphasizes Nagrath.

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With the help of researchers at Indiana University School of Medicine, the researchers tested their new knowledge in the laboratory. Six gene modified mice with ovarian cancer were treated with the new method - for all six animals the cancer went into remission and the tumor cells disappeared completely.

Personalized therapies improve effectiveness of cancer therapies

"Personalized therapies like this are increasingly becoming an opportunity to improve the effectiveness of cancer therapies," explains Abhinav Achreja, a co -author of the study. “There are several approaches to discover personalized target molecules for cancer, and several platforms predict target molecules based on big data analyzes. Our platform makes predictions by taking the metabolic functionality and mechanism into account, which increases the chances of success in implementation. ”

, as the Scitechdaily portal reports, is the behavior that reveals this weak point in most cancer - the algorithms could therefore be are also used for other types of cancer. (Tab)

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usr: 1
This is interesting!