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World When a DNA Test says you’re a younger man, who lives 5,000 miles away

03:05  08 december  2019
03:05  08 december  2019 Source:   msn.com

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Three months after his bone marrow transplant, Chris Long of Reno, Nev., learned that the DNA in his blood had changed. It had all been replaced by the DNA of his donor, a German man he had exchanged just a handful of messages with.

Mr. Long had become a chimera, the technical term for the rare person with two sets of DNA . The word takes its name from a fire-breathing creature in Greek mythology composed of lion, goat and serpent parts. Doctors and forensic scientists have long known that certain medical procedures turn people

a man standing in front of a mountain: Chris Long agreed to serve as a guinea pig for his colleagues’ experiment to help them understand how a bone marrow transplant could confuse a criminal investigation.© Tiffany Brown Anderson for The New York Times Chris Long agreed to serve as a guinea pig for his colleagues’ experiment to help them understand how a bone marrow transplant could confuse a criminal investigation.

Three months after his bone marrow transplant, Chris Long of Reno, Nevada, learned that the DNA in his blood had changed. It had all been replaced by the DNA of his donor, a German man he had exchanged just a handful of messages with.

He’d been encouraged to test his blood by a colleague at the Sheriff’s Office, where he worked. She had an inkling this might happen. It’s the goal of the procedure, after all: Weak blood is replaced by healthy blood, and with it, the DNA it contains.

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When A DNA Test Says You ' re A Younger Man , Who Lives 5 , 000 Miles Away . After a bone marrow transplant, a man with leukemia found that his donor's DNA traveled to unexpected parts of his body. A crime lab is now studying the case.

St Clair said she's come a long way since that shocking moment in 2016 when she learned the It made sense then, that her older siblings decided to gift St Clair a DNA test for her birthday in 2016. They knew she would love it — and sure enough, St Clair could scarcely wait to submit her DNA and

But four years after his lifesaving procedure, it was not only Long’s blood that was affected. Swabs of his lips and cheeks contained his DNA — but also that of his donor. Even more surprising to Long and other colleagues at the crime lab, all of the DNA in his semen belonged to his donor. “I thought that it was pretty incredible that I can disappear and someone else can appear,” he said.

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When investigators tested his DNA to do a DNA comparison there was a silly little joke around the office. While this is seemingly hoaky a lot of celebs have used the witness protection program among many other government escape routes to get away from the limelight after becoming to famous.

Long had become a chimera, the technical term for the rare person with two sets of DNA. The word takes its name from a fire-breathing creature in Greek mythology composed of lion, goat and serpent parts. Doctors and forensic scientists have long known that certain medical procedures turn people into chimeras, but where exactly a donor’s DNA shows up — beyond blood — has rarely been studied with criminal applications in mind.

Tens of thousands of people get bone marrow transplants every year, for blood cancers and other blood diseases including leukemia, lymphoma and sickle cell anemia. Though it’s unlikely that any of them would end up as the perpetrator or victim of a crime, the idea that it was possible intrigued Long’s colleagues at the Washoe County Sheriff’s Department, who have been using their (totally innocent) colleague in IT as a bit of a human guinea pig.

a person sitting at a desk in front of a computer: Four years after the bone marrow transplant, Mr. Long’s semen contained 100 percent of his donor’s DNA.© Tiffany Brown Anderson for The New York Times Four years after the bone marrow transplant, Mr. Long’s semen contained 100 percent of his donor’s DNA.

Where will the DNA go?

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They' re not wrong: DNA is the most accurate forensic science we have. It has exonerated scores of people convicted based on more flawed disciplines like The doctor who treated him said Anderson remained in bed through the night. Harinder Kumra had said the men who killed Raveesh rampaged

Answer a DNA test away . By Anita Creamer - The Sacramento Bee. DNA testing has become so widespread among amateur genealogists that the kits proved to be a popular holiday gift item. But it was through testing his Y- DNA that he found distant cousins who can also trace their ancestry to an

The implications of Long’s case, which was presented at an international forensic science conference in September, have now captured the interest of DNA analysts far beyond Nevada.

The average doctor does not need to know where a donor’s DNA will present itself within a patient. That’s because this type of chimerism is not likely to be harmful. Nor should it change a person. “Their brain and their personality should remain the same,” said Andrew Rezvani, the medical director of the inpatient Blood & Marrow Transplant Unit at Stanford University Medical Center.

He added that patients also sometimes ask him what it means for a man to have a woman’s chromosomes in their bloodstream or vice versa. “It doesn’t matter,” he said.

But for a forensic scientist, it’s a different story. The assumption among criminal investigators as they gather DNA evidence from a crime scene is that each victim and each perpetrator leaves behind a single identifying code — not two, including that of a fellow who is 10 years younger and lives thousands of miles away. And so Renee Romero, who ran the crime lab at the Washoe County Sheriff’s Office, saw an opportunity when her friend and colleague told her that his doctor had found a suitable match on a donor website and he would be undergoing a bone marrow transplant.

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DNA testing can be used in child maintenance or inheritance disputes, or applications for contact with a child or for a child to settle in the UK. find out who inherits an estate when someone has died. If you ’ re ordered to get a test by the Child Maintenance Service, they’ll tell you which laboratory to use.

If you ’ re fully outbred (which you aren’t), you should have 256 great-great-great-great-great-great-grandparents. But their genetic contribution to Before long, you will find ancestors from whom you bear no DNA . They are your family, your blood, but their genes have been diluted out of your bloodline.

The Washoe County Sheriff’s Office in Reno, Nev., ran an informal experiment that could have broader criminal implications.© Tiffany Brown Anderson for The New York Times The Washoe County Sheriff’s Office in Reno, Nev., ran an informal experiment that could have broader criminal implications.

“We need to swab the heck out of you before you have this procedure to see how this DNA takes over your body,” she recalled telling him.

Long agreed. He welcomed an intriguing distraction from his diagnosis of acute myeloid leukemia and myelodysplastic syndromes, both of which impair the production of healthy blood cells.

At the time, he said, “I didn’t even know if I would live.”

Four years later, with Mr. Long in remission and back at work, Ms. Romero’s experiment persisted, aided by her crime lab colleagues. Within four months of the procedure, Mr. Long’s blood had been replaced by his donor’s blood. Swabs collected from his lip, cheek and tongue showed that these also contained his donor’s DNA, with the percentages rising and falling over the years. Of the samples collected, only his chest and head hair were unaffected. The most unexpected part was that four years after the procedure, the DNA in his semen had been entirely replaced by his donor’s.

“We were kind of shocked that Chris was no longer present at all,” said Darby Stienmetz, a criminalist at the Washoe County Sheriff’s Office.

If another patient responded similarly to a transplant and that person went on to commit a crime, it could mislead investigators, said Brittney Chilton, a criminalist at the Sheriff’s Office forensic science division.

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And it has misled them, Ms. Chilton learned once she began to research chimerism. In 2004, investigators in Alaska uploaded a DNA profile extracted from semen to a criminal DNA database. It matched a potential suspect. But there was a problem: The man had been in prison at the time of the assault. It turned out that he had received a bone marrow transplant. The donor, his brother, was eventually convicted.

Abirami Chidambaram, who presented the Alaska case in 2005, when she worked for the Alaska State Scientific Crime Detection Laboratory in Anchorage, said she had heard about another disconcerting scenario since then. It involved police investigators who were skeptical of a sexual assault victim’s account because she said there had been one attacker, though DNA analysis showed two. Eventually, the police determined that the second profile had come from her bone marrow donor.

Similar scenarios could also create confusion around a victim’s identity — and in fact, it has, said Yongbin Eom, a visiting research scholar at the University of North Texas Center for Human Identification. In 2008, he was trying to identify the victim of a traffic accident for the National Forensic Service in Seoul, South Korea. Blood showed that the individual was female. But the body appeared to be male, which was confirmed by DNA in a kidney, but not in the spleen or the lung, which contained male and female DNA. Eventually, he figured out that the victim had received a bone marrow transplant from his daughter.

The specifics of Mr. Long’s situation raise an inevitable question: What happens if he has a baby? Would he pass on the genes of his German donor or his own to future offspring? In this case, the answer will remain untested because Mr. Long had a vasectomy after his second child was born.

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Live Science is supported by its audience. When you purchase through links on our site, we may earn an affiliate commission. But most people who know me probably wouldn't be surprised to learn that most of my ancestors lived in shtetls in Eastern Europe.

But what about everyone else? Three bone marrow transplant experts who were surveyed agreed that it was an intriguing question. They also agreed that passing on someone else’s genes as a result of a transplant like Mr. Long’s was impossible.

“There shouldn’t be any way for someone to father someone else’s child,” said Dr. Rezvani, the Stanford medical director.

That’s not to say that other forms of chimerism haven’t created comparably confusing scenarios. Fraternal twins sometimes acquire each other’s DNA in the womb; in at least one case that led to unfounded fears of infidelity when a man’s child did not seem to be his. In another case, a mother nearly lost custody of her children after a DNA test.

But a donor’s blood cells should not be able to create new sperm cells, Dr. Rezvani said. Dr. Mehrdad Abedi, the doctor at the University of California, Davis, who treated Mr. Long, agreed: He believed it was Mr. Long’s vasectomy that explained how his semen came to contain his donor’s DNA. The forensic scientists involved say they plan to investigate further.

Everyone who has reviewed Mr. Long’s case agrees on one thing: He is a living, breathing case study of one, and it’s impossible to say how many other people respond to bone marrow transplants the same way he did. It’s simply one of those curious possibilities that forensic analysts may want to consider when DNA results are not adding up.

For his part, Mr. Long said he hopes to meet his donor during an upcoming trip to Germany and to thank him in person for saving his life.

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