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World Hydroxychloroquine and chloroquine not effective and even harmful according to a study

00:28  23 may  2020
00:28  23 may  2020 Source:   parismatch.com

Hydroxychloroquine: Olivier Véran requests a revision of the prescription rules

 Hydroxychloroquine: Olivier Véran requests a revision of the prescription rules © Copyright 2020, L'Obs The Minister of Health Olivier Véran asked the High Council for Public Health (HCSP) on Saturday to propose "within 48 hours a review of the derogatory prescription rules ”for various treatments such as hydroxychloroquine, after the publication of a study showing its ineffectiveness and its risks for Covid-19 patients.

According to the Swiss-registered organization, Medicines for Malaria Venture, chloroquine is a The CDC cited a study , documented in the journal Bioscience Trends this month, that chloroquine phosphate Both chloroquine and hydroxychloroquine , however, are reportedly well-tolerated in

But Mr. Trump continued to champion hydroxychloroquine , prompting criticism even from his favorite television A small study in Brazil of patients taking a high dose of chloroquine — a On April 24, the F.D.A. issued a warning about hydroxychloroquine and chloroquine , cautioning against their

A large study published Friday in the scientific journal "The Lancet" shows that chloroquine and its derivative hydroxychloroquine increase the risk of death and cardiac arrhythmia.

  Hydroxychloroquine et chloroquine pas efficaces et même néfastes d'après une étude © LOUAI BESHARA / AFP

Neither chloroquine nor its derivative hydroxychloroquine prove effective against Covid-19 in hospitalized patients, and these molecules even increase the risk of death and cardiac arrhythmia, warns a large study published in The Lancet on Friday, which recommends not to prescribe them outside of clinical trials.

Carried out on nearly 15,000 patients, this is the "first large-scale study" to show "robust statistical evidence" that these two treatments that are so much in the news, "do not benefit patients of Covid- 19 ", said in a statement Dr Mandeep Mehra, lead author of the study published in the prestigious medical journal.

UK healthcare workers begin COVID-19 hydroxychloroquine trial

  UK healthcare workers begin COVID-19 hydroxychloroquine trial British healthcare workers will on Thursday begin taking part in a University of Oxford-led international trial of two anti-malarial drugs to see if they can prevent COVID-19, including one U.S. President Donald Trump says he has been taking. The 'COPCOV' study will involve more than 40,000 frontline healthcare workers from Europe, Africa, Asia and South America to determine if chloroquine and hydroxychloroquine are effective in preventing the novel coronavirus. © ShutterStock Demand for hydroxychloroquine surged after Trump touted it in early April. Earlier this week the U.S.

“We really do not know if chloroquine or hydroxychloroquine are beneficial or harmful against Covid-19. The best way to find out if they are effective in Health workers who take part will be randomly allocated either the trial drug or a placebo. In Asia, the trial drug will be chloroquine and in Europe

The malaria drugs hydroxychloroquine and chloroquine did not help coronavirus patients and may have done harm, according to a new study based on the records of nearly 15,000 patients Even so, the authors of the study recommended that the drugs not be used outside clinical trials, and they said

These patients received four different combinations based on chloroquine (an antimalarial) and hydroxychloroquine (prescribed for rheumatoid arthritis for example): the treatments were either administered alone or combined with an antibiotic from the macrolide family.

The study analyzed data from approximately 96,000 patients infected with the SARS-CoV-2 virus admitted to 671 hospitals between December 20, 2019 and April 14, 2020, discharged or deceased since. About 15,000 of them received one of the four combinations (chloroquine alone or combined with the antibiotic, hydroxychloroquine alone or combined with the same antibiotic), then these four groups were compared to the 81,000 patients in the control group who did not not received this treatment.

Donald Trump reveals that he is taking hydroxychloroquine

 Donald Trump reveals that he is taking hydroxychloroquine © Brendan Smialowski US President Donald Trump answers questions from journalists from the White House May 18, 2020 US President Donald Trump revealed on Monday that he was taking 'hydroxychloroquine, a drug against malaria, the possible efficacy of which against the coronavirus has not been rigorously demonstrated at this stage. "I have been taking it for a week and a half (...) I hear a lot of extraordinarily positive things" about this drug, said Mr.

The 'COPCOV' study will involve more than 40,000 frontline healthcare workers from Europe, Africa, Asia and South America to determine if chloroquine and hydroxychloroquine are effective in preventing the novel coronavirus. Demand for hydroxychloroquine surged after Trump touted it in

Hydroxychloroquine (HCQ), sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine .

Result, the four treatments were all associated with a much higher risk of mortality than in the control group (which was 9.3%): 16.4% of deaths from chloroquine alone, 22.2% when combined with the antibiotic; 18% for hydroxychloroquine alone, and 23.8% when it was combined with the same antibiotic.

"34% to 45%" more risk of mortality

The authors estimate that the risk of mortality is 34% to 45% higher in patients taking these treatments than in patients with comorbidity factors, c that is, risk factors.

They also discovered serious serious cardiac arrhythmias more frequent in patients receiving chloroquine or hydroxychloroquine, especially with the combination hydroxycholroquine / macrolide (8% of the patients against 0.3% in the control group).

The risk of arrhythmia would be ultimately five times higher with the intake of these two molecules, even if the cause and effect link is not directly proven, explain the authors who request an "urgent" confirmation via clinical trials randomized (patients chosen by lot) before any conclusion.

Read: Exclusive interview with Didier Raoult, "I am a renegade"

Stressing that preliminary small-scale studies have already "failed to identify robust evidence of a benefit" of these two treatments, "we now know with our study found that the chances of improving "the condition of Covid-19 patients" are rather slim, "writes Dr. Frank Ruschitzka, of the Zurich University Hospital, co-author.

While several countries such as Brazil are betting on the use of chloroquine and its derivative, the study recommends that these treatments not be administered outside of clinical trials.

Hydroxychloroquine is currently being tested in several clinical trials, including the European Discovery trial.

WHO reports most coronavirus cases in a day as cases approach 5 million .
WHO reports most coronavirus cases in a day as cases approach 5 millionThe global health body said 106,000 new cases of infections of the novel coronavirus had been recorded in the past 24 hours, the most in a single day since the outbreak began.

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