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World Trump is taking two experimental drugs for COVID-19 - what are they?

13:06  03 october  2020
13:06  03 october  2020 Source:   news.sky.com

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Covid - 19 Live Updates: Trump to Undergo Tests at Walter Reed National Military Medical Center. President Trump received an experimental drug for what the Mr. Trump is also taking vitamin D, zinc, melatonin, a daily aspirin and famotidine (an antacid better known as Pepcid), the memo said.

After being diagnosed with COVID - 19 , President Trump departs the White House for a multi-day stay at Walter Reed Medical Center The rest of the first family has tested negative. Earlier on Friday, the White House chief of staff and press secretary maintained that Trump was still involved in governing

Donald Trump has been given two experimental drugs after testing positive for COVID-19.

a man wearing a suit and tie: Donald Trump is receiving remdesivir therapy at the Walter Reed Military Hospital © Reuters Donald Trump is receiving remdesivir therapy at the Walter Reed Military Hospital

White House doctor Sean Conley said the president was given a dose of an antibody drug being developed by Regeneron on Friday before he was taken to a military hospital where he has started remdesivir therapy.

The president appeared upbeat as he landed at the Walter Reed Military Hospital in Maryland on Friday evening despite developing fatigue symptoms and having trouble breathing, according to an adviser.

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That Trump has contracted COVID - 19 well into the pandemic means that, unlike those who were sickened early on, the President will benefit from “We have learned that patients can be infectious before they are symptomatic, and that it appears they are likely most infectious around the time their

1. Trump in hospital after Covid-positive test. According to the White House, Mr Trump is "fatigued but in good spirits" and has been taken to The president received an experimental drug cocktail injection at the White House after he and First Lady Melania Trump both tested positive for Covid - 19 .

Sky News looks at what remdesivir and Regeneron's drug do, and how effective they have been in trials.

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What is remdesivir?

A drug that once offered hope in the treatment of Ebola, remdesivir is an antiviral medicine that has not been approved anywhere in the world for any use.

It is injected into the vein in the hope it will prevent SARS CoV-2 (the virus that causes COVID-19) from multiplying in the body, with some patients recovering faster after using it.

Gilead Sciences Inc began research on remdesivir in 2009 as part of studies into hepatitis C and respiratory syncytial virus (RSV), a common and highly contagious respiratory virus that most children get before they turn two.

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Mr Trump - who had a fever - said early on Friday he and First Lady Melania Trump had tested positive for Covid - 19 . The White House said he was feeling "fatigued but in good spirits" and was experiencing mild symptoms. The news comes just over a month before presidential elections, where he will face

The drug repeatedly pushed by Trump , hydroxychloroquine, has only shown anecdotal promise. The drug is used to treat malaria, arthritis and The president’s own public health advisers, who stood with him in the briefing room on Saturday, have warned against taking hydroxychloroquine for Covid - 19 .

After scientists in China determined the new pneumonia-like illness was caused by a coronavirus, Gilead provided remdesivir to China to test the drug against the virus.

Remdesivir is thought to interfere with the mechanism that certain viruses use to make copies of themselves, but scientists are still determining how that occurs.

Several clinical trials and laboratory studies have taken place since January, with some promising signs.

However, a report published in The Lancet medical journal on 3 October looking at several studies has found remdesivir "did not appear to affect rates of SARS CoV-2 viral load decline and mortality".

It said using remdesivir early "substantially decreased" viral loads but this effect was "completely lost" when the drug was given just eight hours after infection.

The report concluded that remdesivir "might require initiation before the peak viral replication" but that is "not feasible" in humans as they display symptoms after the virus multiplies.

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President Donald Trump has been treated for COVID - 19 with a 'cocktail' of antibodies produced by Regeneron, his doctor announced on Friday, and is They are quarantining in the White House. Last photo before diagnosis: Donald Trump returns to the White House from his helicopter Marine One on

US President Donald Trump has said he and First Lady Melania Trump have tested positive for coronavirus and A week after Donald Trump told Americans not to worry about Covid - 19 because "it affects Media captionCoronavirus symptoms: What are they and how long should I self-isolate?

It added that there is no clinical reason why remdesivir could not be administered before someone shows symptoms.

What is the experimental Regeneron treatment?

Drug maker Regeneron provided a dose of its experimental antibody treatment to the president on Friday before the decision to take him to Walter Reed was made.

Still in large-scale clinical trials, the new antiviral antibody "cocktail" works by binding to a protein on the surface of the virus.

This is meant to stop the virus from attaching to cells and replicating, while allowing the immune system to attack the virus.

Mr Trump was given a single 8g dose, which should "last for quite a long time", Regeneron chief executive Dr Leonard Schleifer told CNN.

Last weekend, the drug started being used in "about three hospitals in the north" of England as part of Oxford University's national recovery trial, Professor Peter Horby told the BBC.

The specialist in emerging infectious diseases at the University of Oxford said the drug is "very promising" and "very potent".

This class of drugs is "pretty safe and well understood" so is something he has "confidence in", he said.

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Donald Trump has clear risk factors - including his age, weight and being male - that all An early analysis of more than 100 studies, taking in data from around the world, showed the risk for It says eight out of 10 Covid deaths in the country have been in the over-65s. And people in Mr Trump 's age

Trump is 74 years old, putting him at higher risk of serious complications from the virus. They were on their way to Minnesota when this photograph was taken . Senior staff have been tested for Covid - 19 daily since two people who work at the White House complex tested positive in early May

He added that about four or five hundred patients have been given it so far and there have been "no worrying safety signals", with the plan to roll it out to another 30 to 40 UK hospitals next week.

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Prof Horby said a single dose of the treatment provides "prolonged protection" for "a month to six weeks".

Dr Jeremy Faust, an emergency doctor at Brigham and Women's Hospital in Boston, said he would not give it to his patients because he could not say what the benefit is, or the risks.

He added that giving an unproven treatment to the president "sends a message that they're scrambling".

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