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World Prostate cancer: an antidepressant from the 1950s, useful for treating it

20:40  24 november  2020
20:40  24 november  2020 Source:   medisite.fr

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Prostate cancer is cancer of the prostate . The prostate is a gland in the male reproductive system that surrounds the urethra just below the bladder. Most prostate cancers are slow growing. Cancerous cells may spread to other areas of the body, particularly the bones and lymph nodes.

Prostate cancer treatment can include active surveillance, surgery, radiation therapy, hormonal therapy, chemotherapy, immunotherapy, and supportive care. Get detailed treatment information for newly diagnosed and recurrent prostate cancer in this summary for clinicians.

november prostate cancer awareness month, adult man holding light blue ribbon with mustache for supporting people living ... © Istock november prostate cancer awareness month, adult man holding light blue ribbon with mustache for supporting people living ...

The results of a small trial clinical findings suggest that the seventy-year-old antidepressant phenelzine helps shrink tumors in men whose prostate cancer has come back after surgery.

Do you know the phenelzine ? This is a drug in the monoamine oxidase inhibitor (MAOI) family, used in the treatment of depression. In France, it is marketed under the name NARDIL®. This molecule has been around since the years 1950 , but nowadays it is used much less, due to possible interactions with other drugs.

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Antidepressants could stop the spread of prostate cancer to the bones, which kills 90 per cent of men who die from the disease. Scientists have found a chemical linked to depression may help prostate cancer invade the bones. The protein in the brain, which cuts levels of 'happy hormones'

After initial treatment for prostate cancer , PSA levels are expected to drop dramatically. Diagnosing and treating prostate cancer . Several tests may be used to diagnose prostate cancer . At Cancer Treatment Centers of America®(CTCA), our prostate cancer experts treat all stages of the disease.

But if phenelzine is talking about it today, it is for a completely different use… Researchers at the University of Southern California, in the United States, have shown its possible effectiveness in the treatment of cancer prostate . Their results were published in the journal Prostate Cancer and Prostatic Diseases.

Phenelzine: effective in treating prostate cancer

In addition to playing a role in depression, the enzyme called " monoamine oxidase " is also known to help prostate cancer cells to grow. The use of phenelzine therefore helps to interrupt the signals that testosterone sends to tumors to encourage them to grow.

But unlike hormone therapy , it does not block the production of testosterone and thus prevents its unpleasant side effects, such as hot flashes, fatigue, impotence, muscle wasting or weakened bones.

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Prostate cancer is the most common cancer in men. Learn the signs and symptoms of prostate cancer , along with causes and treatments . Benign prostatic hyperplasia (BPH). BPH results from the prostate growing larger. BPH causes symptoms by creating pressure on the bladder, urethra, or

Prostate cancer treatment can include active surveillance, surgery, radiation therapy, hormonal therapy, chemotherapy, immunotherapy, and supportive care. Normal prostate and benign prostatic hyperplasia (BPH). A normal prostate does not block the flow of urine from the bladder.


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Phenelzine reduces PSA levels in 55% of patients

The researchers therefore gave this drug to 20 men including cancer of the prostate had reappeared after surgery. The participants were given doses similar to those used to treat depression (between 60 mg and 90 mg ), twice a day, for 12 weeks.

Result: This antidepressant reduced levels of prostate specific antigen protein ( PSA ) in 55% of men - a rate that allows doctors to monitor the progression of prostate cancer. In five participants, PSA levels fell by at least 30% , and this decrease even reached 74% for one of the volunteers.

Some candidates have experienced side effects : dry mouth, fatigue and light dizziness. However, we are a long way from the serious side effects of hormone therapy.

This antidepressant may reduce the duration of hormone therapy

Scientists believe that the use of phenelzine is not intended to replace hormone therapy. But it could make it possible to reduce the doses of hormones required, and therefore the heavy adverse effects linked to the lack of testosterone, or else be used as a first step, in order to delay the use of hormone therapy and thus reduce the duration of this treatment.

Professor Nicholas James, director of prostate and bladder cancer research at the Institute of Cancer Research in London, believes that finding a new use for existing drugs is a quick way to introduce new s treatments. And for good reason, the drugs already on the market are available quickly, and we already know their possible side effects and contraindications.

However, this clinical trial has only been performed on a small number of participants, and therefore deserves to be further .

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