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Canada Some coronavirus vaccines claim to be over 90% effective. What does that mean?

17:45  25 november  2020
17:45  25 november  2020 Source:   globalnews.ca

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Pfizer and BioNTech announced Monday their coronavirus vaccine was more than 90 % effective in preventing Covid-19 among those without evidence of prior infection, hailing the The final vaccine efficacy percentage may vary, however, as safety and additional data continue to be collected.

Pfizer announced positive early results from its coronavirus vaccine trial What Does 95% Effective Mean ? fall, Pfizer’s chief executive, Dr. Albert Bourla, frequently claimed that the company could have some indication of whether the vaccine worked by October, something that did not come to pass.

In recent weeks, several developers working to create the world's first viable vaccine candidate for the novel coronavirus have shared results from their preliminary and late-stage trials, touting high efficacy rates of 90 per cent and above.

a person in a blue shirt: Doctor in protective gloves & workwear filling injection syringe with COVID-19 vaccine. © Getty Images Doctor in protective gloves & workwear filling injection syringe with COVID-19 vaccine.

Moderna first released its results on Nov. 16, claiming its vaccine candidate was 94.5 per cent effective against COVID-19, based on preliminary data from an ongoing study. Pfizer followed shortly after, announcing two days later that its candidate was 95 per cent effective based on a final analysis from its Phase 3 clinical trial.

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AstraZeneca on Monday became the third pharmaceutical company to announce positive results from late-stage trials of a coronavirus vaccine , saying that its candidate, developed by Oxford University, is up to 90 % effective .

“These vaccines are going to be approved and then rolled out with basically a few months worth of data. Fifteen were adults over the age of 65. Moderna said it plans to apply for emergency use The goal is to provide enough coronavirus vaccine doses to all Americans who want to be

On Monday, AstraZeneca joined them, touting a combined efficacy rate of 70 per cent based on one dosing regimen that proved 90 per cent effective and another that was 62 per cent effective.

Read more: Pfizer says final results show coronavirus vaccine is 95% effective, no safety concerns

Here's what those numbers actually mean.

How effective a vaccine is has to do with observations made during each of its trials. In both the Pfizer-BioNtech and Moderna trials, one group of test subjects was given the vaccine while the other was given a placebo.

Dr. Eric Arts, Canada Research Chair in Infectious and Parasitic Diseases at Western University, said scientists get to the efficacy number by comparing the outcomes of those who got the vaccine and those who received a placebo dose.

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What is vaccine ‘ effectiveness ’ anyway? Some political leaders have suggested that society will Since COVID-19 coronavirus vaccines are still under development, now is the time to set Of course, how long this takes depends upon how the virus and the response to it may evolve over time.

Pfizer and BioNTech have announced that their coronavirus vaccine is 95 percent effective in preventing infections, with A final analysis of the vaccine ’s Phase-Three trial, involving over 43,000 volunteers, showed that 170 cases of coronavirus were detected among volunteers, with only eight

"You look at how many people didn't receive the vaccine and how many people got infected in that case and how many people did receive the vaccine and how many people got infected. The ratio of those two is your efficacy," he said.

Achieving an efficacy rate of 95 per cent isn't easy. In fact, Arts called it "exceptional," saying the Pfizer candidate "probably is one of the most effective vaccines that has been described."

Dr. Horacio Bach, an adjunct professor for the University of British Columbia's Division of Infectious Diseases, said it would be near impossible for any vaccine to maintain a 100 per cent efficacy rate, as "not everyone is the same."

There are a multitude of reasons a vaccine could work on 90 per cent of people and not the other 10 per cent, he said. This can include a person's genetics, an improperly administered shot or the simple off-chance that a particular dose just didn't work.

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"The virus basically is taken by these antibodies and destroyed by specific cells in the body, in the blood," said Bach. "That is a very complex system."

Read more: Moderna’s coronavirus vaccine is 94.5% effective, company says

But even if a vaccine was only 30 per cent effective and distributed to an entire nation's high-risk population, Arts said that "30 per cent of the people who potentially would be infected now are not infected."

"That is billions of dollars in savings for the Canadian government and probably thousands of lives saved every year in Canada," he said.

"So you can't really make an assessment of when a certain efficacy makes sense and when it doesn't make sense."

A solid benchmark for what a vaccine's efficacy rate should be is also almost entirely up for debate, although the U.S. Food and Drug Administration has set the cut-off for authorizing the emergency use of a COVID-19 vaccine at 50 per cent.

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According to the U.S. Centers for Disease Control and Prevention, the highest rate of effectiveness the flu vaccine has ever gotten for people aged six months and older was 52 per cent this year, although Bach said the rate varies because a vaccine is developed for a different strain of the virus each year.

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Both the HPV4 and HPV9 vaccines are nearly 99 per cent effective on girls and women 12 to 26 years old, but that number can drop to as low as 84 per cent for men in the same age demographic, the Public Health Agency of Canada said.

Meanwhile, the Canadian government has said that vaccinations for hepatitis A can range between 80 per cent and 90 per cent depending on if a person has already been exposed to the virus.

Art said the efficacy of the virus is expected to drop as more and more people take the vaccine, until herd immunity can be reached.

Read more: AstraZeneca says late-stage trials show coronavirus vaccine ‘highly effective’

However, if too many people don't take the vaccine, Arts said "we're in for a very, very long fight" against the virus. He expressed concerns about misinformation about the vaccine's "toxicity" and negative side effects, adding that so far, results have shown "very minimal if any toxicity."

"My biggest fear is that people won't take the vaccine because they get the impression that it won't make a difference," he said.

"In the end, we're all in the same boat."

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