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Canada Trudeau says he wants an AstraZeneca shot — but a supply crunch could be coming

00:50  21 april  2021
00:50  21 april  2021 Source:   cbc.ca

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Canadian Prime Minister Justin Trudeau said Sunday he ’ll deploy additional health-care workers and equipment to help Ontario, the country’s most populous province, which is struggling to contain a sharp rise in Covid-19 cases. In a video posted on Twitter, Trudeau said he ’s working with provinces and territories that could help, including Newfoundland and Nova Scotia, with a particular focus on reducing infection rates in Toronto, the country’s largest city. From mobilizing health care workers, to boosting rapid testing, to coordinating with provinces and territories, we ’ re putting everything on the table to

The AstraZeneca shot was supposed to be the vaccine for a couple of billion people. It is inexpensive at just a couple of dollars per dose and can be stored in an ordinary fridge unlike the mRNA vaccines. Now many physicians and scientists fear the public’s response to AstraZeneca ’s missteps—which included earlier reports of muddled test results and confusing dosing schedules. Could AstraZeneca ’s actions undermine the public’s trust in what clinical trials showed is a safe and effective vaccine, one that many hope would be instrumental in ending the global pandemic?

a person standing in front of a computer: Joan Fisher gets a dose of the AstraZeneca COVID-19 vaccine at the Guardian Snowdon Pharmacy, located at 264 Bloor St. W., in Toronto on Wednesday, March 17, 2021. (Sam Nar/CBC) © Sam Nar/CBC Joan Fisher gets a dose of the AstraZeneca COVID-19 vaccine at the Guardian Snowdon Pharmacy, located at 264 Bloor St. W., in Toronto on Wednesday, March 17, 2021. (Sam Nar/CBC)

Prime Minister Justin Trudeau said today his office was busy working the phones to secure him an appointment to get the AstraZeneca shot at a pharmacy, now that age restrictions for the vaccine have been adjusted in Ontario.

Speaking in French, Trudeau said he was eager to get the AstraZeneca shot in particular "to convey the message to all Canadians that they should be vaccinated with the first one that is offered to them as quickly as possible."

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He said a ban would imperil the UK's vaccination drive, which has so far been more successful than EU member states' vaccine programmes. Mr Johnson also warned that a ban that extended beyond AstraZeneca 's disputed supply could also block jabs produced for BioNTech/Pfizer in Belgium. "One can 't play with blackmail, having given a lot of first jabs and then run into problems with the second," Jean-Yves Le Drian told France Info radio. Mrs von der Leyen said on Thursday that EU was the "region that exports most vaccines worldwide" and invited other countries to "match our openness".

He raised concerns that the training could be used to gather intelligence on Canada and learn its military techniques in order to use them against the country down the line. 'In these memos, you can see the Trump administration warned Canada that this winter warfare training would transfer knowledge to China that could be used,' he said . Levant said the documents show 'an antipathy toward America' from Trudeau while he wants to 'let China's President XI Jinping save face'.

While the vaccine is safe and effective, it has been the subject of much debate in recent weeks — with competing recommendations about who should get the vaccine and when.

Here's a look at the current state of Canada's AstraZeneca supply and some answers to common questions about vaccine deployment in the months ahead:

How many AstraZeneca doses are there in Canada right now?

Trudeau, 49, may not have much time to secure that vaccine appointment. The country's limited AstraZeneca stockpile is quickly running low as some provinces open up eligibility to younger people. And no one seems to know for certain when the next shipment of this COVID-19 vaccine will arrive.

The federal government had distributed 2,316,000 AstraZeneca doses to the provinces and territories as of Monday. Many of them have been administered already.

How old do you have to be to get the AstraZeneca COVID-19 vaccine in each province?

  How old do you have to be to get the AstraZeneca COVID-19 vaccine in each province? Many provinces have been lowering the age of eligibility for the AstraZeneca vaccine to as young as 40. Here’s a look at the rules, recommendations and age cutoffs across the country.The AstraZeneca-Oxford vaccine against COVID-19 is a non-replicating viral vector vaccine. Unlike Moderna's and Pfizer's mRNA vaccines, it doesn't need to be stored at extremely cold temperatures, and it can be easily administered in pharmacies and doctor's offices. Besides the AstraZeneca brand manufactured by the company itself, the vaccine also comes in a version known as COVISHIELD made by the Serum Institute of India.

PHAC now says it believes Canada's vaccine supply will be sufficient to allow all Canadians wishing to be vaccinated to get their shots by the end of September. In an interview with MSNBC late last month, he said every American who wants a vaccine will be able Trudeau announced Tuesday that 168,000 doses of the Moderna shot are expected to be He can be reached at john.tasker@cbc.ca.

President Biden said he would meet his goal to have enough doses to vaccinate every American adult who wanted it by the end of next month. “There is enough vaccine, that is basically 100 percent unquestionable, for every single, solitary American,” he insisted. At the news conference, Dr. Marks drew a link between the two vaccines, saying the clotting cases were “very, very similar.” The vaccines are based on similar technology, but AstraZeneca ’s has not yet been authorized for emergency use in the United States.

As of last Thursday, 709,000 doses had been used nationwide — but much has changed since Maj.-Gen. Dany Fortin, the military commander leading federal vaccine logistics, delivered that update.

Some jurisdictions were reporting an abundance of the AstraZeneca product when Fortin made his statement — 543,000 doses were sitting unused in Ontario pharmacies, for example — because older Canadians were either reluctant to take this shot or had other options at public health-run clinics.

AstraZeneca-oxford covid vaccine vial. © Jeff Stapleton/CBC AstraZeneca-oxford covid vaccine vial.

Frustrated with the number of shots it had on hand, Quebec gave up on scheduling appointments and launched a series of walk-in clinics.

The largest provinces have now adjusted their age criteria. Based on Statistics Canada data, some 6.3 million more Canadians between the ages of 40 and 54 are now eligible to book appointments to get the AstraZeneca vaccine. Now that this larger age cohort is cleared to get the vaccine, demand almost certainly will outstrip supply.

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  Who have provinces pegged to receive COVID-19 vaccines in the coming weeks? As COVID-19 vaccine supplies ramp up across the country, most provinces and territories have released details of who can expect to receive a shot in the coming weeks. The military commander handling logistics for Canada's vaccine distribution program says there will be enough vaccine delivered to give a first dose before Canada Day to every adult who wants one. Maj.-Gen. Dany Fortin says that's if provinces follow the advice to delay second doses up to four months. He also cautions that it is dependent on having no production delays again. Health Canada anticipates a total of 36.

"I want to stress at present there is no indication that vaccination has caused these conditions," she said . In a joint statement later on Tuesday, French President Emmanuel Macron and Italian Prime Minister Mario Draghi said the EMA's comments were "encouraging". Meanwhile, experts from the World Health Organization (WHO) were also meeting on Tuesday but a spokesman stressed there was "no evidence" that the reported blood clots were linked to the vaccine. The WHO has urged countries not to pause their vaccinations. The suspensions come as much of Europe struggles to control rising

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After Ontario went first in expanding eligibility on Sunday, Alberta, B.C., Manitoba and Quebec have all followed suit — jurisdictions that together account for roughly 86 per cent of the Canadian population. (Quebec said today it would restrict the shot to people age 45 and older.)

So when is the next AstraZeneca shipment coming?

Nobody knows for sure. Supplies could be relatively limited over the next month or more.

Officially, 4.1 million more AstraZeneca doses are expected by Canada Day, but dates for the next set of deliveries have not yet been finalized.

Of the 2.3 million AstraZeneca shots that have been delivered so far, 500,000 were produced by the Serum Institute of India.

That private company, which produces a biologically identical version of the AstraZeneca product, was poised to deliver one million more shots in April and an additional 500,000 in early May. Those shipments have been punted for now.

"We are expecting a delay in the shipment," Joelle Paquette, the director general responsible for vaccine procurement at Public Services and Procurement Canada, said earlier this month.

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As India grapples with a deadly surge in its COVID-19 caseload — the country is posting more than 200,000 new cases a day — the government there has restricted virtually all exports of Serum Institute-made shots, diverting most of the 2.4 million doses the institute churns out each day to the domestic vaccination campaign.

Canada is also expecting 1.6 million AstraZeneca doses by the end of June from Covax, the global vaccine-sharing initiative. The timing of that shipment is also in doubt.

The Serum Institute produces millions of shots for Covax — again, Indian restrictions have delayed those deliveries — but SK Bioscience in South Korea is also a designated manufacturer for the worldwide vaccine alliance.

Airport personal unload the first batch of the AstraZeneca vaccines sent from the Covax facility on Sunday, March 28, 2021, at Adem Jashari airport Pristina, Kosovo. © AP Photo Airport personal unload the first batch of the AstraZeneca vaccines sent from the Covax facility on Sunday, March 28, 2021, at Adem Jashari airport Pristina, Kosovo.

Canada has received 316,000 Korean-made doses from Covax but details about another shipment are scant.

"Delivery schedules are not yet finalized, therefore precise delivery dates are to be determined, but doses are expected this quarter," a government official, speaking on background, told CBC News.

Canada is also poised to receive one million AstraZeneca-made shots in the April-through-June period.

No more walk-in AstraZeneca vaccinations in Montreal

  No more walk-in AstraZeneca vaccinations in Montreal Montrealers will no longer be able to get an AstraZeneca vaccine at a walk-in clinic in Montreal, the city’s public health department announced on Friday. All the doses allocated for the walk-in portion of the effort have been used up. A few doses remain for people who made an appointment to receive the shot in the coming days. “The six health and social services establishments in the Montreal region participating in the COVID-19 vaccination campaign are joining together to highlight the overwhelming success of the walk-in operation that began last Wednesday,” the public health department said in a news release.

Those shots likely will come from U.S. plants but, again, a delivery schedule has not yet been confirmed by procurement officials. Those doses are "expected in June," an official said, but issues at a U.S. plant could still derail those projections.

Could the U.S. help us out and send more doses?

Possibly. The Biden administration sent 1.5 million doses of AstraZeneca to Canada last month.

U.S. regulators haven't even approved that product for use yet in the American marketplace — but the company is still manufacturing it in the United States. More than 20 million doses have been stockpiled already, according to Bloomberg News.

Trudeau has said his government will work with the U.S. to secure more supply.

"We have continued to engage with partners around the world, including the United States, about getting more doses quickly," Trudeau said on April 9.

There's another snag in the U.S. supply chain. A major U.S. supplier of the AstraZeneca product, Maryland-based Emergent Biosolutions, was forced to make adjustments at its plant this week after workers there inadvertently ruined 15 million doses of the Johnson & Johnson vaccine.

a sign on the side of a building: A sign outside the Emergent BioSolutions site in Winnipeg is pictured on Feb. 11, 2021. © Gary Solilak/CBC A sign outside the Emergent BioSolutions site in Winnipeg is pictured on Feb. 11, 2021.

Until now, the Maryland plant had been making supplies for both vaccines — but the Biden administration has demanded that Emergent retool to ensure a steady supply of uncontaminated J&J shots and nothing else.

AstraZeneca will have to find another U.S. partner in short order, which could disrupt manufacturing and deliveries.

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I've already had a dose of AstraZeneca. What does all this mean for me?

The National Advisory Committee on Immunization (NACI) has said the provinces (and territories, although they're much further ahead in the vaccination effort) can wait up to four months between first and second doses.

In most provinces, if you receive a shot today you likely won't be scheduled for a second dose until August. The government has 16 weeks to procure more AstraZeneca doses — or land the ones they've already contracted to receive — to get recipients their second doses.

There's also the possibility that someone who received an AstraZeneca shot could receive a dose of another product at a later date.

a man standing in front of a mirror posing for the camera: Pharmacist Kyro Maseh administers a dose of the AstraZeneca COVID-19 vaccine to Matthew Stone, 46, at a pharmacy in Toronto on Apr. 20, 2021. © Evan Mitsui/CBC Pharmacist Kyro Maseh administers a dose of the AstraZeneca COVID-19 vaccine to Matthew Stone, 46, at a pharmacy in Toronto on Apr. 20, 2021.

A U.K. trial is looking into whether COVID-19 vaccines can be mixed. Researchers are probing whether an AstraZeneca-recipient can get the Pfizer product for the second dose.

"We're seeing some experience and trials going on around the world in terms of a mixed schedule," Dr. Howard Njoo, Canada's deputy chief public health officer, said on April 8, citing the U.K. study.

"We're looking very carefully at that to see what the outcomes are in terms of overall effectiveness and ... certainly that'll be taken into account of what might be put forward here in Canada."

Is the shot safe?

Following reports of rare blood clotting events among some who received the AstraZeneca vaccine, Health Canada officials reaffirmed last week they still believe the product is safe — and Canadians should have no qualms about rolling up their sleeves for it when the time comes.

NACI was expected to provide an update on its AstraZeneca-related guidance today but that press conference was cancelled at the last minute.

In a statement, Health Canada said the immunization advisory committee "postponed the planned release of its guidance ... in order to further validate its data analysis. NACI expects to be able to release its finalized guidance later this week."

Health Canada has said that if regulators conclude at any time that the risks of the AstraZeneca shot outweigh its benefits, the department won't hesitate to pull the vaccine's authorization.

Who have provinces pegged to receive COVID-19 vaccines in the coming weeks? .
As COVID-19 vaccine supplies ramp up across the country, most provinces and territories have released details of who can expect to receive a shot in the coming weeks. The military commander handling logistics for Canada's vaccine distribution program says there will be enough vaccine delivered to give a first dose before Canada Day to every adult who wants one. Maj.-Gen. Dany Fortin says that's if provinces follow the advice to delay second doses up to four months. He also cautions that it is dependent on having no production delays again. Health Canada anticipates a total of 36.

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