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Technology Scientists genetically modify mosquitoes to resist all dengue viruses

18:02  17 january  2020
18:02  17 january  2020 Source:   cnet.com

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Scientists modified female Aedes aegypti mosquitoes with the antibody against the virus . The mosquitoes appear to be unable to spread any According to the National Center for Biotechnology Information, dengue is the "fastest spreading mosquito -borne viral disease in the world."

Researchers at Johns Hopkins Bloomberg School of Public Health (https://www.jhsph.edu/) have genetically modified mosquitoes to resist infection from dengue

Getting a mosquito bite can be more than just annoying. If the pest is carrying a virus like dengue, it can make you sick with fever, rash and extreme pain or it can even kill you. But a team of researchers may have a solution. Scientists from the Australia national science agency CSIRO and the University of California-San Diego have engineered the first genetically modified mosquitoes resistant to spreading all four types of the dengue virus.

a close up of a person: A team working with Professor Omar Akbari of UC-San Diego has engineered mosquitoes that repel the four known times of dengue virus. Erik Jepsen/UC San Diego Publications © Provided by CNET A team working with Professor Omar Akbari of UC-San Diego has engineered mosquitoes that repel the four known times of dengue virus. Erik Jepsen/UC San Diego Publications a insect on the ground: The Aedes aegypti mosquito spreads dengue virus. Erik Jepsen/UC San Diego Publications © Provided by CNET The Aedes aegypti mosquito spreads dengue virus. Erik Jepsen/UC San Diego Publications

"Recent advances in genetic engineering technologies have made it possible to create mosquitoes with reduced vector competence, limiting their ability to acquire and transmit pathogens," scientists stated in a research paper published Thursday in the medical journal PLOS Pathogens,

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Researchers have genetically modified mosquitoes to resist infection from dengue virus , a virus that sickens an estimated 96 million people globally from research organizations. Researchers create mosquito resistant to dengue virus . Boosting natural ability of mosquito to fight disease could

Genetically modifying mosquitoes to prevent disease may sound like science fiction, but the Ways to use genetically modified mosquitoes . There are two alternative methods currently used to Estimated range of the dengue and Zika virus carrying mosquito species in the United States

a insect on the ground: University of California San Diego Associate Professor Omar S. Akbari holds up genetically-modified mosquitoes resistant to spreading dengue. © Erik Jepsen/UC San Diego Publications

University of California San Diego Associate Professor Omar S. Akbari holds up genetically-modified mosquitoes resistant to spreading dengue.

Scientists modified female Aedes aegypti mosquitoes with the antibody against the virus. The mosquitoes appear to be unable to spread any form of the debilitating disease.

"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," study author and UC-San Diego Professor Omar S. Akbari said in a statement. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."

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Scientists say they have created mosquitoes resistant to the dengue virus , which might eventually help control The team at Johns Hopkins Bloomberg School of Public Health in Baltimore genetically modified Aedes aegypti mosquitoes to boost their natural ability to fight infection by the virus .

Thousands of genetically modified mosquitoes will be released in Panama in an attempt to stop the spread of the dengue virus . The Aedes aegypti mosquito is the primary vector of dengue . For the project, scientists will genetically alter male mosquitos by putting a sterility gene into the

The research could eventually change the lives of millions of people. According to the National Center for Biotechnology Information, dengue is the "fastest spreading mosquito-borne viral disease in the world."

"We are already in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, Yellow Fever and Chikungunya," Akbari said.

The mosquitoes in the study were tested in CSIRO's bio-containment site specifically designed for research of dangerous infectious agents.

The study found that the new genetically engineered mosquitoes outperform mosquitoes armed with bacterium Wolbachia pipientis approved by the EPA in 2017.

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