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Tech & Science A new milestone for using Crispr gene-editing against cancer

10:11  07 february  2020
10:11  07 february  2020 Source:   msn.com

The Startling Secret of an Invincible Virus

  The Startling Secret of an Invincible Virus A phage that resists all forms of the antiviral defense known as CRISPR has an unusual means of survival.The viruses that Bondy-Denomy studies at the University of California at San Francisco don’t bother humans. Known as phages, they infect and kill bacteria instead. Bacteria can defend themselves against these assaults. They can recognize the genes of the phages that threaten them, and deploy scissorlike enzymes to slice up those genes and disable the viruses. This defense system is known as CRISPR. Billions of years before humans discovered it and used it as a tool for editing DNA, bacteria were using CRISPR to fight off phages.

They represent a stepping stone that doesn't yet prove Crispr can be used to fight cancer . Indeed, one of the patients has since died and the disease They then used a virus to arm the T-cells to attack a protein typically found on cancer cells called NY-ESO-1, and infused the cells back into the patients.

They represent a stepping stone that doesn't yet prove Crispr can be used to fight cancer . Indeed, one of the patients has since died and the disease has Researchers at the University of Pennsylvania (UPenn) removed T-cells from the patients' blood and used CRISPR to delete genes from the cells

A lab technician prepares to thaw a blood bag before genetically modifying a patient's immune cells on March 8, 2019 at the Paoli-Calmettes Institute (IPC) overall cancer care center in Marseille, southeastern France © GERARD JULIEN A lab technician prepares to thaw a blood bag before genetically modifying a patient's immune cells on March 8, 2019 at the Paoli-Calmettes Institute (IPC) overall cancer care center in Marseille, southeastern France

US scientists have succeeded in genetically editing the immune systems of three cancer patients using Crispr, without creating any side effects, a first for the tool which is revolutionizing biomedical research.

The highly anticipated results from the first phase of a clinical trial were published in the journal Science on Thursday. 

They represent a stepping stone that doesn't yet prove Crispr can be used to fight cancer. Indeed, one of the patients has since died and the disease has worsened in the other two -- but the trial does show that the technique is non-toxic.

'I can't hide I'm 60 as everyone saw me hit 30': Nigella Lawson says she's determined to embrace her age despite admitting she finds milestone 'odd'

  'I can't hide I'm 60 as everyone saw me hit 30': Nigella Lawson says she's determined to embrace her age despite admitting she finds milestone 'odd' 'I can't hide I'm 60 as everyone saw me hit 30': Nigella Lawson says she's determined to embrace her age despite admitting she finds milestone 'odd'Others may pretend to be younger, but the TV cook hasn't been able to tinker with the truth since her 30th birthday party, having deliberately written her age on the invitations.

They represent a stepping stone that doesn't yet prove Crispr can be used to fight cancer . Indeed, one of the patients has since died and the disease has Researchers at the University of Pennsylvania (UPenn) removed T-cells from the patients' blood and used CRISPR to delete genes from the cells

They represent a stepping stone that doesn't yet prove Crispr can be used to fight cancer . Indeed, one of the patients has since died and the disease has Researchers at the University of Pennsylvania (UPenn) removed T-cells from the patients' blood and used CRISPR to delete genes from the cells

Researchers at the University of Pennsylvania (UPenn) removed T-cells from the patients' blood and used CRISPR to delete genes from the cells that might interfere with the immune system's ability to fight cancer.

They then used a virus to arm the T-cells to attack a protein typically found on cancer cells called NY-ESO-1, and infused the cells back into the patients.

Edward Stadtmauer, the study's principal investigator, told AFP that T-cell therapy, in which a person's own immune system is exploited to destroy tumors, had been a major breakthrough of the past decade, but "unfortunately, even with that technology  there are so many patients who don't respond."

The idea of this work therefore is to combine the two cutting-edge approaches to make T- cells even more powerful.

There may not have been major clinical results this time around, but "to me the import of this study is not the clinical results but the fact that we were able to feasibly do this very complex procedure," added Stadtmauer.

Olivia Newton-John gives update on cancer battle - and it’s positive .
Olivia Newton-John threw her hands to the sky as she discussed her illnessWhen asked by Lisa "on behalf of everyone in Australia" how she was, 71-year-old Olivia threw her fists into the air as she told the audience: "I'm doing really well... Thank you for your love and support, I really appreciate it." The Grease star added: "My last MRI, which is an exam where they look inside, things are shrinking and going away, or staying the same, and I'm living well with it and feeling great.

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