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UK News Man is first to receive arthritis drug in trial to treat Covid-19

03:25  28 september  2020
03:25  28 september  2020 Source:   dailymail.co.uk

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41, becomes first in the UK to receive experimental arthritis drug in trial to treat Covid - 19 Received dose of otilimab - potential arthritis treatment - to see effect on Covid Study trial is being funded by GlaxoSmithKline who aim to recruit 800 patients UK patient to be given an experimental arthritis drug in a clinical trial to treat severe Covid - 19 .

COVID ‑ 19 drug development is the research process to develop preventative therapeutic prescription drugs that would alleviate the severity of coronavirus disease 2019 ( COVID ‑ 19 ).

a group of people in a room: MailOnline logo © Provided by Daily Mail MailOnline logo

A Manchester man has become the first UK patient to be given an experimental arthritis drug in a clinical trial to treat severe Covid-19.

Farhan Hamid, 41, is in intensive care at Manchester Royal Infirmary.

He has received a dose of otilimab – which is under investigation as a potential treatment for rheumatoid arthritis – in hopes that this drug could also ease the effects of Covid-19.

Mr Hamid is part of the Otilimab in Severe Covid-19 Related Disease (Oscar) study which aims to determine whether the drug can treat the severe lung disease caused by the virus.

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Software suggested an arthritis drug might quell an out-of-control immune response that This week, Lilly announced it is working with the US National Institute of Allergy and Infectious Diseases on a large clinical trial of the drug in hospitalized Covid - 19 “We don’t know how to treat these patients.”

"Avifavir is Russia's first Covid - 19 drug and has shown high efficacy in treating patients with coronavirus during clinical trials . Avifavir has received a registration certificate from the Ministry of Health of the Russian Federation. Thus, Avifavir has become the first Favipiravir-based drug in the

a group of people in a room: Farhan Hamid, 41, has become the first UK patient to be given an experimental arthritis drug in a clinical trial to treat severe Covid-19 at Manchester Royal Infirmary © Provided by Daily Mail Farhan Hamid, 41, has become the first UK patient to be given an experimental arthritis drug in a clinical trial to treat severe Covid-19 at Manchester Royal Infirmary

The trial at the Manchester hospital is led by Dr Andy Martin. He said: 'The patients eligible to take part in this study are those experiencing very severe lung difficulties due to Covid-19 and are receiving oxygen or ventilator support.

'We are conducting this study to see whether otilimab – which is under investigation as a potential treatment for rheumatoid arthritis – could also ease the effect of coronavirus on the lungs, dampening the impact of the virus on the immune system.'

Oscar is funded by UK-based pharmaceutical giant GlaxoSmithKline, which aims to recruit 800 patients globally for the study. Trials are also under way in the US and results are expected in the first half of 2021.

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Our picks for COVID - 19 : how to treat coronavirus at home. What are the differences between colds Patients can take paracetamol or ibuprofen when self-medicating for symptoms of COVID - 19 , such as If you are asked to attend whilst isolating or you have concerns, call the practice or hospital first .

Last month, the drug reportedly received approval as an experimental treatment for COVID - 19 infections, Pharmaceutical Technology reported. Doctors are using the same drug in Japan to treat coronavirus patients with mild to moderate symptoms, The Guardian reported.

a group of people standing in a room: He has received a dose of otilimab ¿ which is under investigation as a potential treatment for rheumatoid arthritis ¿ in hopes that this drug could also ease the effects of Covid-19 © Provided by Daily Mail He has received a dose of otilimab ¿ which is under investigation as a potential treatment for rheumatoid arthritis ¿ in hopes that this drug could also ease the effects of Covid-19

GSK has said it is aiming to conduct the study at five hospitals in the UK.

Those taking part will be allocated into two groups at random, with half receiving a one-hour, single infusion of otilimab, while others get a placebo intravenous therapy, in addition to standard care.

Dr Tim Felton, a senior lecturer at the University of Manchester and clinical lead for all Covid-19-related studies at Manchester University NHS Foundation Trust, said: 'The primary end point of this study is that participants are alive and free of lung failure after 28 days - so this research is potentially life-saving.'

a man in a striped shirt in front of a brick building: Dr Tim Felton is a senior lecturer at the University of Manchester and is the clinical lead for all Covid-19-related studies at Manchester University NHS Foundation Trust © Provided by Daily Mail Dr Tim Felton is a senior lecturer at the University of Manchester and is the clinical lead for all Covid-19-related studies at Manchester University NHS Foundation Trust

Christopher Corsico, senior vice president development at GSK, said: 'We are continuing to work hard to find solutions to address the pandemic, including exploring potential treatment options for Covid-19 patients.

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The first trial , announced one week ago and being conducted by the University of Queensland, is There are many benefits to looking at existing drugs to treat Covid - 19 , as they have already been Covid - 19 is an exceptional case because it is novel, is rapidly spreading, and countries are uniting to

"These findings suggest that famotidine may affect the course of COVID - 19 ." The researchers report they all felt nearly back to normal two weeks after taking "One of the authors decided to treat a family member and a few friends after learning more about the emerging famotidine trial because it has

'We know that some Covid-19 patients experience an overreaction of their immune system - sometimes referred to as cytokine storm - which can lead to hospitalisation or death.

'We believe that otilimab might be able to help counter or calm this process.'

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