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UK News osteoarthritis: the zebrafish, a hope of treatment against the disease?

17:40  29 november  2021
17:40  29 november  2021 Source:   medisite.fr

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Arthrose : le poisson-zèbre, un espoir de traitement contre la maladie ? © Adobe Stock osteoarthritis: the zebrafish, a hope of treatment against the disease?

The zebrafish has the ability to reconstitute its fin. French researchers identified the process that allows this regeneration, paving the way for new tracks to allow the regeneration of certain tissues in the treatment of degenerative diseases such as osteoarthritis.

Could a fish be the solution for a future treatment against osteoarthritis? The future of regenerative medicine would be in a fish, Danio Rerio, more commonly known as zebrafish. According to a study of the researchers of the Inserm and the University of Montpellier published in the journal Nature Communications on November 3rd, this fish with the ability to regenerate its caudal fin would be able to tell us how to treat degenerative diseases like the osteoarthritis. Scientists have indeed sought to identify the structure that orchestrates this regeneration process in zebrafish. This phenomenon is made possible by the formation of a blastème, a group of cells that initiate and controls the regeneration of the tissue. By reaching the ability of the zebrafish to reconstitute its fin, researchers open avenues for the progress of regenerative medicine. The orchestrating cells identified

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in fact, according to the Inserm communiqué, published on November 23, surprisingly, the zebrafish is capable of

regenerating its caudal fin when it was amputated, "grace to the transitional formation of a mass of cells called blastem ". In previous works, Farida Djouad, Director of Research at Inserm, and his team had demonstrated "the unprecedented role of macrophages, immune system cells, when training the zebra fish. The researchers had managed to prove "that macrophages orchestrate the inflammatory processes necessary for the proliferation of the cells of the blastème and the regeneration of the caudal fin".

In their new study, these scientists were further exploration of this blast and revealed "the major involvement of a new cell population, the neural peak derived cells". These cells are present in all vertebrates, including in the human species, and play a key role in the development of the embryo. According to the Inserm's release, the Montpellier researchers' team has managed to demonstrate that "

the neural peak cells orchestrate the regeneration process of the fin, by dialogue with macrophages and with the other cells of the Blastème to control and regulate their answer ". "New tracks for regeneration of tissues"

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knowing that these are the

interactions of these cells within the blastème with the macrophages that allow the regeneration of the zebrafff fish, the researchers wonder why it is The only mammal to be able to reconstitute his fin. "Why mammals, which also have macrophages and derived cells from the neural ridge fail to regenerate their appendages as does the zebrafish?", Ask Farida Djouad, Director of Research at Inserm . The work carried out on several animal models capable of regeneration have for "purpose of to identify the 'conductor cell, common to all the regeneration processes ". "A better understanding of its role, and especially the factors that it secretes could pave the way to new tracks to promote the regeneration of certain tissues in the treatment of degenerative diseases such as osteoarthritis ", concludes the researcher .

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