US News: Humans Can Regrow Cartilage in Joints Using 'Salamander-like' Ability - PressFrom - United Kingdom
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US News Humans Can Regrow Cartilage in Joints Using 'Salamander-like' Ability

06:05  10 october  2019
06:05  10 october  2019 Source:   newsweek.com

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Humans have a salamander - like ability to regrow cartilage in joints , a team of scientists has found. They also found that humans make use of some of the same molecules—called microRNA—that are key to limb regeneration in salamanders and other animals which can regrow

Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to “We believe that an understanding of this ‘ salamander - like ’ regenerative capacity in humans , and the critically missing components of this

a green frog: A Mombacho salamander (Bolitoglossa mombachoensis), a species endemic to Nicaragua and in danger of extinction, is pictured at the Mombacho Volcano Natural Reserve in Granada, Nicaragua, on March 18, 2017. © INTI OCON/AFP/Getty Images A Mombacho salamander (Bolitoglossa mombachoensis), a species endemic to Nicaragua and in danger of extinction, is pictured at the Mombacho Volcano Natural Reserve in Granada, Nicaragua, on March 18, 2017.

Humans have a salamander-like ability to regrow cartilage in joints, a team of scientists has found.

Salamanders are well-known for being able to regrow new limbs, but it turns out that a similar process takes place in the human body, according to a study published in the journal Science Advances.

The scientists from Duke Health identified a mechanism for cartilage repair that they say could have important implications, potentially opening the door to new treatments for osteoarthritis—the world's most common joint disorder—as well as methods to grow human body parts.

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Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs "We believe that an understanding of this ' salamander - like ' regenerative capacity in humans , and the critically missing

Cartilage in human joints can repair itself through a process similar to creatures such as salamanders and zebrafish to regenerate limbs, Duke Health found. “We believe that an understanding of this ‘ salamander - like ’ regenerative capacity in humans , and the critically missing

Osteoarthritis knee . film x-ray AP ( anterior - posterior ) and lateral view show narrow joint space, osteophyte ( spur ), subchondral sclerosis, inflammation, OA Osteoarthritis knee . film x-ray AP ( anterior - posterior ) and lateral view show narrow joint space, osteophyte ( spur ), subchondral sclerosis, inflammation, OA

"We believe that an understanding of this 'salamander-like' regenerative capacity in humans, and the critically missing components of this regulatory circuit, could provide the foundation for new approaches to repair joint tissues and possibly whole human limbs," Virginia Byers Kraus, a senior author of the study from the departments of Medicine, Pathology and Orthopedic Surgery at Duke, said in a statement.

For the research, the scientists used a technique known as "mass spectrometry" to determine the age of cartilage throughout the body. This analysis revealed that cartilage has different "ages" depending on where it is located: young in the ankles, middle-aged in the knees and old in the hips.

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Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs "We believe that an understanding of this ' salamander - like ' regenerative capacity in humans , and the critically missing

Humans possess a salamander - like ability to regrow cartilage in joints , contrary to popular belief. Researchers have found potent molecules in the body which encourage the growth of new proteins in the connective tissue. The process is similar to that of salamanders, lizard-like amphibians famed for

Male Traumatologist orthopedics surgeon doctor examining middle aged man patient to determine injury, pain, mobility and to diagnose medical treatment. © edwardolive Male Traumatologist orthopedics surgeon doctor examining middle aged man patient to determine injury, pain, mobility and to diagnose medical treatment.

"In our efforts to understand the proteins in cartilage, we discovered big differences in the chemical modifications of the proteins in hip, knee and ankle cartilages," Kraus told Newsweek. "These types of modifications build up if the tissue is not repairing or turning over—the process of getting rid of old protein while making new protein."

"Hip cartilage proteins had an abundance of chemical modifications of proteins while the knee had moderate amounts and the ankle very few proteins with these chemical modifications," she said. "This showed that the ankle was in a high state of repair or turnover, the hip in a low state of repair and the knee in between."

These results mimic those seen in animals which regenerate their limbs beginning at the furthest tips.

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Cartilage in human joints can repair itself through a process similar to that used by animals such as salamanders and zebrafish to regenerate limbs She said: “We believe that an understanding of this salamander - like regenerative capacity in humans , and the critically missing components of this

Our bodies have retained the capacity to repair injured or overworked cartilage in our joints , says new research published today in Science Advances. The axolotl is particularly special in that it can regrow its limbs, organs, and even portions of its brain. That humans cannot regrow entire limbs is

specialist watching image of knees and lower limbs at x-ray film viewer © endopack specialist watching image of knees and lower limbs at x-ray film viewer

"In searching for an explanation for these different levels of repair ability, we considered the possibility of salamander limb regeneration because their limbs regenerate best at the ends—the hands and feet," Kraus said.

They also found that humans make use of some of the same molecules—called microRNA—that are key to limb regeneration in salamanders and other animals which can regrow body parts, such as zebrafish, African fresh water fish and other lizards.

"In human cartilage, these [molecules] were present at a high level in human ankle cartilages, intermediate in knees and low in hips and strongly related to the 'age'—amount of chemical modifications—of proteins at the three joint sites," Kraus said.

Young woman's hand touching her knee during running time on footpath. Joint pain. Sporty problem and solution. Close up. Front view. Young woman's hand touching her knee during running time on footpath. Joint pain. Sporty problem and solution. Close up. Front view.

"Our results suggest that the principles underlying limb regeneration in limb regenerating animals involving regenerative microRNA, appear to be a biologic principle underlying the natural repair capability of human cartilage. To our knowledge, this is the first insight that human cartilage repair is linked to processes used in limb regeneration," she said.

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Research links human ability to regrow cartilage to molecules that help amphibians sprout new Contrary to popular opinion, humans can regrow cartilage in their joints , researchers have found. “We like to call it our inner salamander ,” said Prof Virginia Kraus, the co-author of the research from

Humans possess a salamander - like ability to regrow cartilage in joints , contrary to popular belief. Researchers have found potent molecules in the body The process is similar to that of salamanders, lizard-like amphibians famed for their remarkable ability to recover from damage to their body.

According to the researchers, the results could provide an explanation for why ankle injuries tend to heal quicker than knee and hip injuries, and why the latter two develop into arthritis less frequently.

The study has significant implications, the team say, because it broadens our understanding of the microRNAs—which could be developed into medicines to treat or even reverse arthritis.

"The traditional view has been that cartilage lining the joints throughout the body is all the same and does not repair or regenerate," Kraus said. "This research shows that cartilage at different sites is different and that cartilage has has a natural repair capacity that varies by joint site."

"The implications are far-reaching, suggesting new treatments based on boosting, with regenerative microRNA, the natural human ability to repair cartilage," she said. "We think of it as "boosting our inner salamander capacity". We wonder, might it be possible to someday regenerate a human limb based on a deeper knowledge of how humans and salamanders are alike and unalike."

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