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US News Covid-19: doctors are trying to understand why the symptoms persist in some patients

08:55  23 november  2020
08:55  23 november  2020 Source:   lejdd.fr

As Christmas approaches, a gloomy atmosphere in the shopping districts

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Symptoms of COVID - 19 are variable, but usually include fever and a cough. People with the same infection may have different symptoms , and their symptoms may change over time.

COVID - 19 (coronavirus): Long-term effects. COVID - 19 symptoms can sometimes persist for COVID - 19 can also weaken blood vessels and cause them to leak, which contributes to potentially However, researchers recommend that doctors closely monitor people who have had COVID - 19 to

Plusieurs équipes se penchent sur les séquelles protéiformes de la pathologie. © Sipa

Several teams are looking into the protean sequelae of the pathology.

They developed a mild form of Covid-19 and were not hospitalized. These patients thought they did well. But several months after their infection, some doubt to find "the life of before". What if the persistent symptoms they complain about, sometimes debilitating, turn into lasting sequelae? Despite the impatience of patients, it takes time to assess the long-term effects. In the absence of conclusions, the medical community has forged a conviction: it is crucial to study in depth this protean pathology of the "long Covid".

The United Kingdom is going to do this with the networking of forty health establishments. This is also the ambition of the national Cocolate survey, which Olivier Robineau, doctor in the infectious diseases department of the Dron hospital center in Tourcoing (North), has been coordinating since September. Nearly 1,000 symptomatic patients will be followed for one year, every four months (blood, physical and mental tests), in partnership with twenty other hospitals. "Even if it only affected 1% of patients, advance Olivier Robineau, reported to the millions of French infected, it could affect 80,000 people, with serious consequences for public health."

Coronavirus: how to explain the low number of daily cases in Paris

 Coronavirus: how to explain the low number of daily cases in Paris © Ludovic MARIN / AFP As the second wave sweeps over France, Paris has few new daily cases compared to its population. The department is even the 14th department where there are fewer cases. An exception when the virus is developing rapidly in metropolitan areas. The second wave is "massive, deadly and straining caregivers and our entire health system". This is how the Director General of Health, Jérôme Salomon, described the French health situation on Tuesday evening.

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Hibbert and other doctors are finding that some patients infected with the novel coronavirus have a propensity towards developing blood clots, which "There's overexuberant clotting going on with Covid patients , and we ' re trying to keep ahead of it." While studies sort this out, doctors are being extra

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vaccine 5 to 10% of patients still complain of symptoms six months after

It is estimated that 5 to 10% of patients complain still showing symptoms six months after infection. They are said to be 60,000 in the United Kingdom. Research from King's College in London, pre-published at the end of October and involving more than 4,000 positive patients, suggests that one in 20 people experience symptoms beyond eight weeks; and one in 50 more than twelve weeks later. In France, a study from the Rennes University Hospital of 300 non-serious patients showed that, after six weeks, half said they had not recovered their previous state of health. "Nevertheless, reassures Pierre Tattevin, head of department in this hospital and president of the French-speaking infectious pathology society, with hindsight, we confirm that it does not worsen and that in general it improves over time . "

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So getting COVID - 19 can feel a bit like playing craps, in more ways than one. Let’s take the duration That means half the patients were still shedding the virus and potentially contagious well into the What if you’ve had COVID - 19 symptoms but no longer do? Surely, you are no longer contagious if

Why would anyone want to do this? You would think the Government would be pulling out all the 2. If you have the same symptoms as flu or pneumonia you must be put down as Covid - 19 and not as Covid - 19 has certainly been a serious disease, but the flu epidemics of 1957 and 1967 were just as

Figures from studies and monitoring of cohorts in the general population are expected in December in France. "We will have the answer not only on the prevalence of persistent Covid, hopes Olivier Robineau, but also on the link between the symptoms and the virus. Everything suggests that it exists, but a demonstration is needed."


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Their symptoms reappear after periods of calm

The profile of these "long courses" differs from that of hospitalized patients. According to researchers at King's College, the most vulnerable to long forms are those over 70, young women (50% more likely than men), people with a greater number of different symptoms during the first week, as well as asthmatics. A small study conducted by Dominique Salmon-Céron, professor of infectious diseases at Hôtel-Dieu (AP-HP), not published to date and relating to 70 patients who tested positive, also indicates that it is generally sick between 35 and 50 years, including a large proportion of women.

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Covid - 19 is typically signaled by three symptoms : a fever, an insistent cough and shortness of breath. But older adults — the age group most at risk of severe Data collection of atypical symptoms . So far, reports of cases like these have been anecdotal. But a few physicians are trying to gather more

COVID - 19 Timeline. Incubation - how long before symptoms start? The incubation period of an infection is the time between being exposed to it and Some countries only test (and confirm) coronavirus in people with severe infection, and it's not known if the incubation period for people with

Their symptoms, now better described and classified, often reappear after periods of calm. "Like pushes", notes Dominique Salmon-Céron, who groups them into five categories. First, intense fatigue. "An intolerance to the slightest effort in people who were very active," she explains. Neurological signs, including "brain fog" (problems with concentration and memory) and sensory disturbances. Cardio-thoracic disorders (tachycardia, chest tightness, hypertension or hypotension, etc.). Finally, digestive signs (diarrhea, nausea) and skin signs (inflammation, frostbite). In addition, joint pain, tingling…

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We have the impression that these patients have expended a lot of energy to defend themselves against the virus and pay it off in the process

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In the United Kingdom, the Coverscan study aims to decipher the long-term impact of Covid-19 on the organs of young so-called "low-risk" patients. Preliminary results from 200 patients aged 44 on average suggest that, four months after their illness, nearly 70% have damage to one or more organs, including the heart, lungs, liver and pancreas. "The good news is that the damage is mild," said cardiology professor Amitava Banerjee in the British daily The Guardian, adding that in 25% of people two or more organs are affected. If correlations are sometimes underlined between the affected organ and the type of symptom, the study does not prove that the deficiencies are the cause.

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Long-term effects

To date, the causes of this polymorphic pathology are still unknown. "It can be immunological, says Professor Tattevin. We have the impression that these patients have spent a lot of energy to defend themselves against the virus and pay for it in the process."

Is this an inflammatory immune reaction linked to the virus or to the viral DNA that persists? All avenues are explored: immunological, virological, genetic, psychological… The psychosomatic aspect should not be neglected, according to specialists, because anxiety can increase symptoms and their persistence. The vast French Cocolate study should also provide answers on this point. A review by the British National Institute for Health Research recalls that previous coronaviruses have had long-term effects: 30% of survivors of SARS and Mers epidemics have suffered a persistent physiological deterioration, cardiac, pulmonary, glycemic and cerebral complications. and long-term psychological. In those of SARS, symptoms of post-traumatic stress disorder were seen for up to fifty-one months after infection.

Coronavirus: Less than 4,000 patients in intensive care, decline in the main indicators .
The number of people hospitalized is also down, after a peak of more than 33,000 patients on November 16 © SYSPEO / SIPA Disinfection teams, in Nice .

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This is interesting!