US News Plate Sclerosis: The mononucleosis virus in question

20:20  17 january  2022
20:20  17 january  2022 Source:   medisite.fr

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Sclérose en plaques : le virus de la mononucléose en cause © Adobe Stock Multiple Sclerosis: The mononucleosis virus in question

according to a US study published in Science, the Epstein-Barr virus (EBV) , which causes mononucleosis, seems to be a triggering element of the multiple sclerosis. This discovery relaunches the hope of finding treatment to cure this autoimmune disease.

the plate sclerosis (SEP) is most likely caused by the Epstein-Barr (EBV) virus, according to a study published in the Journal Science on January 13, 2022. It was already years already that the hypothesis was studied But it was difficult to prove, especially because the symptoms of the disease started only ten years after the infection and that this virus touches a large part of the world's population.

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Eptein-Barr: 90% of the population affected by the

virus The Epstein-Barr is a very common virus that infects nine people out of ten in the world, most often during childhood or adolescence . To discover its causal link with multiple sclerosis, American researchers followed for 20 years more than 10 million young adults engaged in the US military. Of these, 955 were diagnosed with this autoimmune disease during their service.

based on the results of their research, the risk of developing multiple sclerosis would then multiplied by 32 after being infected with the Epstein-Barr virus, while it remains unchanged after an infection by Other viruses. Specifically, the risk appears as the greatest when contracted the virus during pubert (between 11 and 15 years) and disappears completely after 25 years.

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Scientists recall, however, that if this virus seems to be the trigger element of the SEP, it is not enough for the disease to declare . Other environmental factors come into play such as tobacco, a vitamin D deficiency, obesity during adolescence, or night work.

multiple sclerosis: towards a future treatment?

In France, multiple sclerosis concerns 100,000 young adults , with an average of 5,000 new cases each year . It is an autoimmune disease which affects the central nervous system . "A dysfunction of the immune system causes lesions that cause the motor disturbances, sensory, cognitive, visual or sphincate (most often urinary and intestinal)", details the INSERM. Evolving "pushed", the SEP is very variable from one patient to another. At more or less long term, all these disorders can progress towards irreversible disability.

At present, there is no treatment to heal , but only for to slow the evolution of the disease . This American discovery therefore strongly relaunches the hope of scientists to find one. "It is an important step, because it suggests that most cases of multiple sclerosis could be prevented by stopping the infection with Epstein-Barr virus," said Alberto Ascherio, principal author and professor of Epidemiology at Harvard Public Health School, in a statement. "Aim for this virus could lead to the discovery of a remedy". The scientist argues that an " Vaccine Against EBV " or " Specific Antivirals " could be developed to prevent or treat multiple sclerosis.

Chance of the calendar or not, the American company Modera announced in early January have started clinical trials on humans for an Epstein-Barr virus vaccine using RNA messenger technology.

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