Health & Fit This May Be The 1st New Alzheimer's Drug In Years

19:25  02 january  2018
19:25  02 january  2018 Source:   newsweek.com

Neurologist dispels myths about Alzheimer's disease

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A drug originally designed to treat diabetes has reversed Alzheimer ' s disease symptoms in lab mice. Updated |Promising new animal research suggests a drug originally developed to treat diabetes significantly reverses memory loss and brain degeneration in mice with a rodent version of

Alzheimer ' s disease is a type of dementia that causes problems with memory, thinking and behavior. Symptoms usually develop slowly and get worse Alzheimer ' s is the sixth leading cause of death in the United States. On average, a person with Alzheimer ' s lives four to eight years after diagnosis

a close up of a man © Provided by IBT Media A new promising animal research suggested a drug originally developed to treat diabetes significantly reverses memory loss and brain degeneration in mice with a rodent version of Alzheimer’s disease. If the same is proven true in humans, the drug could one day be used as a treatment for Alzheimer’s disease and other memory-related illnesses.

In the study, published online this week in Brain Research, scientists from Lancaster University in England used lab mice to test how effective a diabetes drug known as a triple receptor was in treating Alzheimer’s disease. The mice in the study were specifically created to express certain genes associated with Alzheimer's disease in humans. The researchers waited for the mice to age before giving them the drug, therefore giving their disease some time to develop and damage the animal’s brain. Once given the drug, the animals were then made to conduct a maze test designed to measure their memory.

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It has long been a controversial theory about Alzheimer ’ s disease, often dismissed by experts as a sketchy cul-de-sac off the beaten path from mainstream research. But a new study by a team that includes prominent Alzheimer ’ s scientists who were previously skeptics of this theory may well

A promising new drug appears to be especially good at sopping up toxic pieces of beta amyloid protein that stick together in the brain and form the clumps that are a key characteristic of Alzheimer ’ s disease, researchers say. WebMD Health News. New Drug Shows Promise Against Alzheimer ' s .

Related: Alzheimer's Disease Might Start In Our Bodies, Not Just Our Brains

Results revealed that after given the drug, aged mice who already had signs of a rodent version of Alzheimer’s disease showed improved learning and memory skills. The results were also seen on a biological level and these mice displayed reduced amounts of plaque buildup in the brain, a major hallmark of Alzheimer’s disease. In addition, these mice also had reduced levels of chronic inflammation in their brains, overall slower rates of brain nerve cell loss, and increased brain nerve cell protection.

The results suggest that the diabetes drug has a "clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer's disease," lead study researcher Christian Holscher of Lancaster University in a statement on Sunday. This is especially exciting, as it has been 15 years since a new Alzheimer’s drug has hit the market.

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Eighteen-month results for a new Alzheimer ' s drug show promise. BAN2401 removed plaque and improved cognition better than a placebo. For patients anxiously waiting for help, Fargo warned that it will be several years before the drug is available, assuming it's successful in the phase three trial

New Alzheimer ' s test can predict age when disease will appear. “ Alzheimer ’ s is considered to be a disease of memory but we now think from our early work that the difficulty people There are several answers, say scientists. Drugs that are currently ineffective may prove far more potent if given during

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The drug is called a triple receptor drug and according to the study, combines GLP-1, GIP and Glucagon, three biological molecules known as as “growth factors.” Growth factors are simply natural substances, usually a hormone or steroid, that help to induce growth. The growth factors in this drug specifically affected growth in the animals' brains, and this is significant as the brains of Alzheimer’s patients are shown to display growth impairment, a statement on the study reported. This impairment causes brain nerve cells to slowly lose function, eventually leading to some of the hallmark symptoms of Alzheimer's disease.

However, in the mice in the study, the diabetes drug prevented and even reversed this brain growth impairment.

The link between diabetes and Alzheimer’s is not as strange as you may think. Insulin, the hormone which diabetes patients have trouble regulating, is actually a type of growth factor. This is why a triple receptor drug was originally designed to treat diabetes. In addition, diabetes patients are more likely to develop Alzheimer’s disease, the Alzheimer’s Association reported.

Alzheimer's epidemic worsens in U.S. .
Daughters, other relatives carry most of the responsibility Alzheimer's disease just keeps getting worse in the U.S. The latest report on the most common cause of dementia shows that 5.7 million Americans have the disease and it's costing us $277 billion a year.That doesn't include the unpaid time and effort of the people, mostly women, who are caring for spouses, parents, siblings, and friends with dementia, the annual report from the Alzheimer's Association shows."In 2017, 16 million Americans provided an estimated 18.

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