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Health & Fit How does flu spread? This experiment seeks answers

21:50  13 february  2018
21:50  13 february  2018 Source:   nbcnews.com

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This experiment seeks answers . newsvire February 14, 2018 Latest News Leave a comment 22 Views. Stefanos Koutsoukos, a College of Maryland scholar, demonstrates the Gesundheit 2 gadget that gathers viruses from exhaled breath for experiments on how flu spreads .

How does flu spread ? A team at the University of Maryland is studying how one person passes influenza virus to another. It’s all part of an experiment to find out just how flu spreads .

Hannah Weisman is clipping Namitha Thomas's fingernails.

This is not a beauty session. Thomas is also giving blood samples and her nose and throat will be swabbed.

It's all part of an experiment to find out just how flu spreads. Thomas and Weisman are students at the University of Maryland, where Dr. Donald Milton and colleagues are taking a deep dive into influenza in one of its richest habitats — a college dormitory.

Thomas has been in close contact with a flu patient, and now Milton's team will watch her and test her to see if and when she comes down with flu herself.

"Who is going to become contagious?" Milton asked.

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How does flu spread ? Follow QuestionFollowing Unfollow. This answer should not be considered medical advice Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD.

CDC: “ How Flu Spreads ,” “ Flu & You.” Cowling, B. , published online May 7, 2008. PLOSOne. More Answers On Cold and Flu . Is there any way to tell if my flu is still contagious? Do flu medicines stop the flu from being contagious?

Hannah Weisman, a neurobiology major at the University of Maryland, helps fellow student Namitha Thomas clip her fingernails as part of a study of how flu spreads. © Provided by NBCU News Group, a division of NBCUniversal Media LLC Hannah Weisman, a neurobiology major at the University of Maryland, helps fellow student Namitha Thomas clip her fingernails as part of a study of how flu spreads.

The tests will help identify the route of transmission — whether people get infected by large droplets of mucus or saliva that carry flu virus into their nasal passages, whether they pick up the virus on their fingers from droplets that have fallen onto surfaces such as desks, or whether they breathe in the virus on tiny, airborne particles.

It's an especially timely experiment. The U.S. is suffering through one of the most severe flu seasons in recent years. Almost every state is experiencing widespread flu activity at the same time — an unusual pattern. Understanding how and when influenza spreads can help doctors understand and, perhaps, better control the annual flu epidemic.

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Signs around the campus urge students to come in if they start feeling ill to be tested for flu. If they are positive, they're asked to give up the names of four close contacts so they can be tested for flu and followed.

Students are also asked to download an app, also designed by a student there that tracks their movements. The cellphone app can show whether they were exposed to roommates or someone in a study room.

College residence halls are perfect breeding ground for respiratory viruses such as flu.

"You're sharing the same air in small rooms," said Dr. Barbara Albert, head clinician helping oversee the study. "They may not even know they've been in contact with somebody else."

Although influenza causes an epidemic every single year, and some years causes a more serious pandemic, how it is transmitted is poorly understood. Scientists estimate that each flu patient infects about one-and-a-half other people on average, a number known as R0 (r zero).

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It's known that people can transmit influenza before they feel sick, and after they feel better, and that the virus spreads on droplets. But more subtle factors may aid the spread of flu.

Facing the sneeze machine

Milton's lab showed earlier this year that flu virus can remain suspended in the air in tiny particles that people emit when they are breathing normally — something that many doctors had believed did not happen.

"We are all breathing out potentially infectious viruses," said Stefanos Koutsoukos, a biochemistry major who is one of 68 students earning college credit while helping with the experiment. "It's led me to think differently about how I may have become sick."

They use Milton's Gesundheit 2 machine to measure this, recruiting patients with flu to sit with their faces in the cone-shaped collection device to see what they send out with each breath.

Gesundheit 2 machineStefanos Koutsoukos, a University of Maryland student, demonstrates the Gesundheit 2 machine that gathers viruses from exhaled breath for experiments on how flu spreads. © Provided by NBCU News Group, a division of NBCUniversal Media LLC Gesundheit 2 machineStefanos Koutsoukos, a University of Maryland student, demonstrates the Gesundheit 2 machine that gathers viruses from exhaled breath for experiments on how flu spreads.

"We are trying to figure out what students are getting sick with," said Christine Shi, a public health major who is working on the experiment. "How much virus do the students emit?"

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If someone develops flu after a close contact has had it, the tests can show how they became infected. Genetic tests can establish if student A infected student B directly.

"We can deep sequence the flu virus and see the source," Milton said. The samples are sent to the University of Maryland's Institute for Genome Sciences for those tests.

Which particles are worse?

A patient's symptoms may be a function of how they caught the virus. Milton has a theory that flu causes worse symptoms if inhaled on tiny, airborne particles rather than from larger particles that are coughed or sneezed out and either breathed in or picked up from a surface.

The smaller particles, he believes, can be sucked directly down into the lungs and lower airways, making people sicker. Students' cellphones are also being swabbed.

"I think infection route matters," Milton said.

They ask about stress, physical activity and sleep. "We are trying to get a broad picture of susceptibility," Milton said.

The team has a grant from the Defense Advanced Research Projects Agency (DARPA) to develop various tests for infection.

"They want to know if we can identify a signal in the blood to tell us who is going to infect everybody else," Milton said.

Last year, a few students showed up with flu but more had other viruses that cause similar symptoms, such as coronaviruses and respiratory syncytial virus or RSV. Out of 72 students tested last year, 13 had RSV-B, 10 had coronavirus OC43, 10 had adenovirus, eight had influenza A, and the rest had an assortment of coronaviruses, RSV strains, rhinovirus and another flu-like virus called human parainfluenza virus.

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Experiment Overview Teaching Tips Tree map Cold and Flu Worksheet Pathogens Test & Answer Key Science Standards. 2 4 6 7 9 13. Now that we know germs cause sickness, how do you think germs are spread ?

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Thomas, a freshman biology major from Ellicot City, Maryland who hopes to study medicine, will come back for regular checkups. "I hope you stay well," Albert tells her as she leaves the lab.

Will she catch flu? "I really hope not," Thomas said.

Flu lab at the University of MarylandDr. Sanmi Adenaiye, a graduate student at the Univerrsity of Maryland, takes blood from Namitha Thomas, a fellow student who has been in close contact with a flu patient. They are studying how influenza spreads. © Provided by NBCU News Group, a division of NBCUniversal Media LLC Flu lab at the University of MarylandDr. Sanmi Adenaiye, a graduate student at the Univerrsity of Maryland, takes blood from Namitha Thomas, a fellow student who has been in close contact with a flu patient. They are studying how influenza spreads.

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