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Health & Fit Doctors Tried Transplants Using Diseased Organs. One Year Later, the Recipients Are Still Disease-Free

23:36  06 march  2018
23:36  06 march  2018 Source:   time.com

Second face transplant for Frenchman in world-first

  Second face transplant for Frenchman in world-first A man whose body rejected a face transplant he received seven years ago has been given a second donor face after living nearly two months without one, French medical agencies said Friday. It is the first time in transplant history that doctors have replaced one donor face with another, according to Olivier Bastien of France's biomedicine agency.

One Year Later , the Recipients Are Still Disease - Free . Getty Images. While they were waiting to receive the transplant , the doctors gave the recipients a dose of an oral pill containing grazoprevir/elbasvir, a drug combination sold under the brandname Zepatier.

1 Year Later , the Recipients Are Still Disease - Free . Discussion in ' Organ transplantation ' started by Dr .Scorpiowoman, Mar 7, 2018. While they were waiting to receive the transplant , the doctors gave the recipients a dose of an oral pill containing grazoprevir/elbasvir, a drug combination sold under

a close up of a logo © Getty Images More than 90,000 people in the U.S. are waiting for a kidney transplant, and new research suggests an unusual approach may help cut down the list: using diseased kidneys.

In a new study published in the journal Annals of Internal Medicine, researchers gave 10 willing people, who were in need of a kidney transplant, kidneys that were infected with hepatitis-C, followed by medication known to clear the infection. All 10 remained free of the disease one year after their landmark transplants.

The trial, which occurred at Johns Hopkins University School of Medicine, is one of a few happening nationwide. Currently, hepatitis-C infected organs are discarded; about 500 kidneys are thrown away each year due to the infection. But in the last few years, several new and highly effective hepatitis-C drugs have been approved. The drugs have been shown to clear the disease up to 98% of the time.

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Doctors Tried Transplants Using Diseased Organs . One Year Later , the Recipients Are Still Disease - Free , Time (March 5, 2018). Patient Ratings & Comments. The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice

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So far, the same appears to be true when diseased organs are transplanted. At Johns Hopkins, researchers approached men and women over age 50 who had been on the waiting list for kidney transplants for an average of more than four months. None of the people had hepatitis C at the time. Ten people—with an average age of 71—agreed to be given hepatitis-C infected kidneys.

While they were waiting to receive the transplant, the doctors gave the recipients a dose of an oral pill containing grazoprevir/elbasvir, a drug combination sold under the brandname Zepatier. The men and women continued to take the pill daily for 12 weeks after the transplant. Three of the people also took another treatment called sofosbuvir (sold under the brandname Sovaldi, among others), to treat their specific strain of hepatitis-C.

Cure for hepatitis C gives hope to kidney patients

  Cure for hepatitis C gives hope to kidney patients Johns Hopkins researchers use drug that cures infectious liver disease to help dialysis patients Researchers from Johns Hopkins have figured out a way to cure kidneys infected with hepatitis C, which would allow them to be used for dialysis patients in desperate need of a transplant.In a small study, 10 kidney patients were treated before transplant surgery with an antiviral medication that prevents hepatitis C from replicating in the body, and continued receiving treatment for 12 weeks after transplant, according to Dr.

Doctors Tried Transplants Using Diseased Organs . One Year Later , the Recipients Are Still Disease - Free , Time (March 5, 2018). Patient Ratings & Comments. The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice

Transplant rejection occurs when transplanted tissue is rejected by the recipient 's immune system, which destroys the transplanted tissue.

The researchers report that five of the transplant recipients never had detectable hepatitis C in their blood. The other people had low levels of the virus that went away within a week. None of the men and women showed any signs of having the disease, and at least a year later, everyone is still healthy. “In this era of organ shortages, it’s difficult to watch good organs get discarded,” said study author Dr. Christine Durand, an assistant professor of medicine at Johns Hopkins University School of Medicine in a statement about the trial. “This was a great opportunity to take a neglected public health resource and put it to good use.”

The opioid epidemic is one of the reasons why there are more potential donor organs infected with hepatitis-C now than in the past. Cases of hepatitis-C nearly tripled from 2010 to 2015, which experts say is due to the rise in injection-drug use.

Organs from drug overdoses could help transplant shortage

  Organs from drug overdoses could help transplant shortage Fatal ODs are increasing organ donations, and research says people who receive those transplants generally fare as well as patients given organs from more traditional donors.Researchers from Johns Hopkins University report those transplants have jumped nearly 24-fold since 2000, to 3,533 transplants in 2016.

In a small study, doctors at Johns Hopkins have successfully transplanted 10 hepatitis C-infected kidneys And hundreds more may never make it to a recipient because some organ procurement Being able to use these organs for transplants could mean many hundreds of lives saved each year .

The disease progresses slowly, ultimately causing end-stage kidney disease in which dialysis and transplantation are the only forms of treatment. Did you know? There are multiple steps in the transplant process: You are evaluated for a transplant by the medical team at a transplant center.

Johns Hopkins is not the only hospital to test hepatitis C-infected organs for transplants. At Penn Medicine in Philadelphia, researchers are testing hepatitis-C infected hearts as well as kidneys for transplant. Every year about 1,000 donor hearts are thrown away due to the infection. At Penn, people are put on hepatitis-C drugs once the virus is detected in their blood.

“Young, otherwise healthy people are dying from a drug overdose,” Dr. David Goldberg, co-leader of the Penn study and an assistant professor of medicine and epidemiology in the Perelman School of Medicine at the University Pennsylvania told TIME in October. “There are a lot of potential donors.”

The Johns Hopkins researchers say more large-scale trials are needed to continue to test the effectiveness and safety of diseased organ transplants, including kidneys, hearts and livers.

Gallery: Doctors reveal the most miraculous recovery they’ve ever seen in a patient (courtesy Reader's Digest) In their own words: We explored a <span href=Reddit thread where doctors and nurses shared the recovery stories that baffled and amazed them. The results show that modern medicine, combined with the power of human determination, can overcome incredible circumstances." data-src="/upload/images/real/2018/03/06/in-their-own-words-we-explored-a-a-href-https-www-reddit-com-r-askreddit-comments-6uol7e-doctors-of-_442504_.img?content=1" src="/img/no_img/content/no_img_content_flip.jpg" lazyload="lazyload" /> Doctors Reveal the Most Miraculous Recovery They’ve Ever Seen in a Patient

Boy, 13, regains consciousness after parents sign papers to donate his organs .
A 13-year-old boy who was declared brain dead defied odds when he regained consciousness after his parents had signed papers to donate his organs. Trenton McKinley, of Mobile, Ala., was hospitalized two months ago after a small utility trailer he was in flipped over.“I hit the concrete and the trailer landed on top of my head. After that, I don't remember anything," Trenton told Fox 10.Trenton suffered seven skull fractures from the accident. His parents recalled doctors saying their son “would never be normal again.”“All I saw was a stretcher with his feet hanging out.

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