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Health & Fit1 in 3 People Could Develop This Alzheimer’s-Like Disease by Age 85

16:11  07 may  2019
16:11  07 may  2019 Source:   rd.com

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A new disease mimics Alzheimer ' s symptoms in people aged 85 and older—but it's entirely different. Get the facts on LATE. “Approximately one in three of all persons over age 85 diagnosed with Alzheimer ’ s may actually have LATE,” says study author Peter Nelson, MD, PhD, a professor at the

A new disease mimics Alzheimer ' s symptoms in people aged 85 and older—but it's entirely different. Get the facts on LATE.

1 in 3 People Could Develop This Alzheimer’s-Like Disease by Age 85© Atthapon Raksthaput/Shutterstock brain scans Each year, 500,000 people learn that they have Alzheimer's, a progressive brain disease marked by problems with memory and thinking that interfere with daily life. Now new research suggests some of these people—especially those aged 85 and older—may actually have a newly coined form of dementia known as LATE: limbic-predominant age-related TDP-43 encephalopathy. The acronym is apt since the condition tends to strike people later in life than Alzheimer's. "Approximately one in three of all persons over age 85 diagnosed with Alzheimer's may actually have LATE," says study author Peter Nelson, MD, PhD, a professor at the University of Kentucky in Lexington. The new report, which appears in the journal Brain, is based on a National Institute on Aging (NIA) project on LATE, and it included researchers from more than 20 institutions in six countries.

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A new disease mimics Alzheimer ' s symptoms in people aged 85 and older—but it's entirely different. Get the facts on LATE. The acronym is apt since the condition tends to strike people later in life than Alzheimer ’ s . “Approximately one in three of all persons over age 85 diagnosed with Alzheimer ’ s

The most common symptoms of Alzheimer ’ s disease appear during stage three—clear, persistent, memory loss. Dr. Porter says patients with mild Alzheimer ’ s disease will need help with handling finances, making travel 1 in 3 People Could Develop This Alzheimer ’ s - Like Disease by Age 85 .

Alzheimer's versus LATE

While Alzheimer's disease is the most common type of dementia, it is far from the only type. There are several lesser-known types that are equally devastating. LATE seems to be the most similar to AD in terms of symptoms, namely memory loss and confusion, but there are some important distinctions. Here's how to know if your memory loss might be Alzheimer's.

For starters, LATE tends to hit people aged 85 and older, while Alzheimer's often starts around age 65 and up. What's more, LATE tends to progress at a slower pace than Alzheimer's—unless the two diseases travel together, in which case there is a more rapid decline. Alzheimer's can have a genetic link, but LATE is not hereditary, says Howard Fillit, MD, founding Executive Director and Chief Science Officer of the Alzheimer's Drug Discovery Foundation. Like Alzheimer's, LATE can only be definitively diagnosed after death during an autopsy of the brain, but the brains of people with LATE look a whole lot different than those of people with Alzheimer's. "With LATE, the brain can look quite devastated in the region that serves to consolidate short-term memory called the hippocampus," Dr. Nelson says. There is also an abundance of a toxic protein called TDP-43 in the brains of people with LATE, which suggests a different cause than Alzheimer's. The tell-tale signs of Alzheimer's in the brain include tangles of a protein called tau along with plaques of amyloid-beta, explains Julie A. Schneider, MD, MS, The Deborah R. And Edgar D. Jannotta Presidential Professor of Pathology and Neurological Sciences Associate Director, Rush Alzheimer's Disease Center, Rush University Medical Center. Alzheimer's damage starts in the hippocampus but eventually attacks other areas of the brain.

Eye exam detects signs of Alzheimer's disease

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Are you worried about Alzheimer ' s ? Healthy lifestyle choices can go far in reducing your risk with this disease . We know a lot about what happens during the course of Alzheimer ' s and how the symptoms affect memory and behaviour. What we don't know is what kicks off that whole process.

It's an exciting time for Alzheimer ' s disease research, with new studies, treatments and answers on the horizon. Here’s what scientists are doing to possibly prevent and reverse the debilitating disease . 1 in 3 People Could Develop This Alzheimer ’ s - Like Disease by Age 85 .

LATE: What's in a name?

"Recent research and clinical trials in Alzheimer's disease have taught us two things: First, not all of the people we thought had Alzheimer's have it; second, it is very important to understand the other contributors to dementia," says Nina Silverberg, PhD, director of the Alzheimer's Disease Centers Program at the NIA, in a news release. Dr. Nelson agrees: "A growing awareness of non-Alzheimer's diseases that underlie the clinical syndrome of dementia will assist in both clinical trials for Alzheimer's, and also for the non-Alzheimer's dementias such as LATE," he says. "I hope that we can now get on to better tailoring the right therapeutic strategies to the right groups of individuals." Time is of the essence, Dr. Fillit adds. "The old-old or individuals aged 85 and older are the fastest growing segment of our population."

Can LATE be treated?

Like Alzheimer's the disease is incurable. Doctors can and do use some of the same drugs to ease symptoms of LATE as they do for Alzheimer's, but in the future, there may be targeted drugs that work better for each type of dementia. And don't fall for false hopes: Here's what the FDA wants you to know about fake Alzheimer's cures.

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Trembling hands could be the result of something as simple as too much caffeine or a side effect of certain medications like asthma drugs and antidepressants. 1 in 3 People Could Develop This Alzheimer ’ s - Like Disease by Age 85 .

Early-onset Alzheimer ' s disease is a rare form of dementia that presents unique challenges. Learn more about causes, diagnosis and how to cope. Of all the people who have Alzheimer ' s disease , about 5 percent develop symptoms before age 65.

When doctors treat cancer today, they analyze a tumor's genetic makeup and pair it with therapies that are more likely to be effective. Such "precision medicine" may one day play a role in treating dementia. "We hope to identify subtypes of dementia with cheap and non-invasive blood tests and then have tailored treatments," Dr. Fillit says. Because of the new report, "we can now say, it's probably LATE, and we know about TDP-43, which ultimately gives us a drug target." Learn more about the differences between dementia and Alzheimer's disease.

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New research gives some biological clues to why women may be more likely than men to develop Alzheimer's disease and how this most common form of dementia varies by sex. At the Alzheimer's Association International Conference in Los Angeles on Tuesday, scientists offered evidence that the disease may spread differently in the brains of women than in men. Other researchers showed that several newly identified genes seem related to the disease risk by sex. require(["medianetNativeAdOnArticle"], function (medianetNativeAdOnArticle) { medianetNativeAdOnArticle.

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