Health & Fit: Cancer Cells Devise Way To Survive Chemotherapy - PressFrom - US
  •   
  •   
  •   

Health & FitCancer Cells Devise Way To Survive Chemotherapy

18:25  18 september  2019
18:25  18 september  2019 Source:   medicaldaily.com

Elephants rarely get cancer – and the reason why could help humans

Elephants rarely get cancer – and the reason why could help humans Elephants have multiple copies of a gene that causes mutated cells to commit suicide, keeping their cancer rates low.

In addition to surviving chemotherapy , these senescent cancer cells produce large amounts of inflammatory molecules and other factors that can promote the tumor's regrowth. Chemotherapy -treated breast cancer patients with normal TP53 genes are therefore prone to

Cancer cells eat the cancer cells around them to survive chemotherapy , explaining how a small proportion sometimes survive . A senescent mouse mammary cancer cell (green membrane) about to consume other cancer cells (red), giving itself a chance to survive bombardment with

Cannibalism among cancer cells is one of the major causes of chemotherapy resistance.

Cancer Cells Devise Way To Survive Chemotherapy© angkhan/Getty Images

Resistance, which occurs when cancers that have been responding to chemo suddenly begin to grow, is normally associated with the massive production by cancer cells of p-glycoprotein pumps, gene amplification and the repair of DNA breaks caused by some anti-cancer drugs such as doxorubicin, among others.

But cannibalism does exist and while uncommon, adds to the burden of curing or mitigating cancer via chemotherapy.

Common Cold Virus Can Attack And Kill Bladder Cancer Cells: Study

Common Cold Virus Can Attack And Kill Bladder Cancer Cells: Study The researchers involved in the small study are hopeful that their findings will help revolutionize treatments for bladder cancer.

Cancer cells become 'cannibals' and eat other tumor cells to beat chemotherapy , study finds Researchers at Tulane University discovered one way breast cancer cells may survive Some cells stop multiplying when treated with chemo - but don't die Some cancer cells turn to cannibalism to dodge the effects of chemotherapy , leaving them to

Sometimes cancer cells from the very beginning can withstand chemotherapy : as it turned out, they receive this "gift" from the proteins of healthy cells surrounding the tumor. In modern medicine, cancer is preferred to treat, causing pinpoint strikes on the tumor.

A new study from Tulane University suggests some cancer cells survive chemotherapy by devouring their neighboring tumor cells in a ruthless bid to withstand chemotherapy. This cellular cannibalism is thought to give predatory cancer cells the energy they need to stay alive. It also allows them to begin tumor relapse after the chemotherapy treatment is completed.

Chemotherapy drugs, among them doxorubicin, kill cancer cells by damaging their DNA. Unfortunately, cancer cells that survive the initial treatment give rise to relapsed tumors.

This is an especially thorny problem in breast cancers that retain a normal copy of a gene called TP53. This protein acts as a tumor suppressor. This means it regulates cell division by keeping cells from growing and proliferating too fast or in an uncontrolled way.

Mom misdiagnosed with cancer underwent chemotherapy, mastectomy, lawyers claim

Mom misdiagnosed with cancer underwent chemotherapy, mastectomy, lawyers claim A mother of two and her lawyers claim that she had already undergone chemotherapy, a mastectomy and reconstructive surgery when she was told that she never even had cancer in the first place. Sarah Boyle, 28, told SWNS that her lawyers obtained an admission of liability from the hospital trust, but she wants more parameters put in place so that it can’t happen to any other patients. require(["medianetNativeAdOnArticle"], function (medianetNativeAdOnArticle) { medianetNativeAdOnArticle.

Chemotherapy ( chemo ) is a treatment of cancer -killing drugs used to kill small cell lung cancer cells . When might chemotherapy be used? Chemo is typically part of the treatment for small cell lung These side effects usually go away after treatment. There are often ways to lessen these side

Researchers from the Tulane University School of Medicine have released footage showing how cancer cells turn to 'cannibalism' to survive

Some cancer cells generally stop proliferating and enter a dormant but metabolically active state known as senescence, instead of dying due to chemotherapy-induced DNA damage. Senescent cancer cells also produce large amounts of inflammatory molecules and other factors that can promote the tumor’s regrowth.

Chemotherapy-treated breast cancer patients with normal TP53 genes become prone to relapse and have poor survival rates.

“Understanding the properties of these senescent cancer cells that allow their survival after chemotherapy treatment is extremely important,” Crystal A. Tonnessen-Murray, a postdoctoral research fellow at James G. Jackson’s laboratory at the Tulane University School of Medicine, who led the research team, said.

Her team also discovered that senescent breast cancer cells frequently engulf neighboring cancer cells following exposure to doxorubicin or other chemotherapy drugs. Researchers observed this surprising behavior in cancer cells grown in the lab and also in tumors growing in mice.

FDA approves Keytruda as treatment for specific type of esophageal cancer

FDA approves Keytruda as treatment for specific type of esophageal cancer The U.S. Food and Drug Administration (FDA) has approved a new treatment.

Chemotherapy ( chemo ) is a treatment of cancer -killing drugs used to kill lung cancer cells . Chemotherapy ( chemo ) is treatment with anti- cancer drugs injected into a vein or taken by mouth. These drugs enter the bloodstream and go throughout the body, making this treatment useful for

What separates the few cancer cells that survive chemotherapy – leaving the door open to recurrence – from those that don’t? Weizmann Institute scientists developed an original method for imaging and analyzing many thousands of living cells to reveal exactly how a chemotherapy drug

They also found that lung and bone cancer cells are also capable of engulfing their neighbors after becoming senescent.

Tonnessen-Murray and her colleagues found that senescent cancer cells activate a group of genes, which are normally active in white blood cells, that engulf invading microbes or cellular debris. They saw that after “eating” their neighboring cancer cells, senescent cancer cells digested them by delivering them to lysosomes, which are acidic cellular structures highly active in senescent cells.

But the most important finding was that this process helps senescent cancer cells stay alive. Senescent cancer cells that engulfed neighboring cells survived in culture for longer than senescent cancer cells that didn’t.

Gallery: What chemotherapy is really like, according to cancer survivors (Reader's Digest)

Cancer Cells Devise Way To Survive Chemotherapy


Read More

10 breast cancer survivors in same family celebrate being disease-free.
The first diagnoses came in 2002, and then nine others followed.

—   Share news in the SOC. Networks

Topical videos:

usr: 4
This is interesting!