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Health & FitCancer Cells Devise Way To Survive Chemotherapy

18:25  18 september  2019
18:25  18 september  2019 Source:   medicaldaily.com

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In addition to surviving chemotherapy , these senescent cancer cells produce large amounts of inflammatory molecules and other factors that can promote the tumor's regrowth. Chemotherapy -treated breast cancer patients with normal TP53 genes are therefore prone to

Cancer cells become 'cannibals' and eat other tumor cells to beat chemotherapy , study finds Researchers at Tulane University discovered one way breast cancer cells may survive Some cells stop multiplying when treated with chemo - but don't die Some cancer cells turn to cannibalism to dodge the effects of chemotherapy , leaving them to

Cannibalism among cancer cells is one of the major causes of chemotherapy resistance.

Cancer Cells Devise Way To Survive Chemotherapy© angkhan/Getty Images

Resistance, which occurs when cancers that have been responding to chemo suddenly begin to grow, is normally associated with the massive production by cancer cells of p-glycoprotein pumps, gene amplification and the repair of DNA breaks caused by some anti-cancer drugs such as doxorubicin, among others.

But cannibalism does exist and while uncommon, adds to the burden of curing or mitigating cancer via chemotherapy.

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Chemotherapy ( chemo ) is a treatment of cancer -killing drugs used to kill small cell lung cancer cells . When might chemotherapy be used? Chemo is typically part of the treatment for small cell lung These side effects usually go away after treatment. There are often ways to lessen these side

Chemotherapy ( chemo ) is a treatment of cancer -killing drugs used to kill lung cancer cells . Chemotherapy ( chemo ) is treatment with anti- cancer drugs injected into a vein or taken by mouth. These drugs enter the bloodstream and go throughout the body, making this treatment useful for

A new study from Tulane University suggests some cancer cells survive chemotherapy by devouring their neighboring tumor cells in a ruthless bid to withstand chemotherapy. This cellular cannibalism is thought to give predatory cancer cells the energy they need to stay alive. It also allows them to begin tumor relapse after the chemotherapy treatment is completed.

Chemotherapy drugs, among them doxorubicin, kill cancer cells by damaging their DNA. Unfortunately, cancer cells that survive the initial treatment give rise to relapsed tumors.

This is an especially thorny problem in breast cancers that retain a normal copy of a gene called TP53. This protein acts as a tumor suppressor. This means it regulates cell division by keeping cells from growing and proliferating too fast or in an uncontrolled way.

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Scientists have developed a promising strategy for defeating certain types of cancer cell that survive chemotherapy . New research finds a way to tackle treatment-resistant cancer cells . The team of researchers tested this new approach in a type of lung cancer in which the cells are able to evade

Chemotherapy is a cancer treatment where medication is used to kill cancer cells . There are many different types of chemotherapy medication, but they all work in a similar way . They stop cancer cells reproducing, which prevents them from growing and spreading in the body.

Some cancer cells generally stop proliferating and enter a dormant but metabolically active state known as senescence, instead of dying due to chemotherapy-induced DNA damage. Senescent cancer cells also produce large amounts of inflammatory molecules and other factors that can promote the tumor’s regrowth.

Chemotherapy-treated breast cancer patients with normal TP53 genes become prone to relapse and have poor survival rates.

“Understanding the properties of these senescent cancer cells that allow their survival after chemotherapy treatment is extremely important,” Crystal A. Tonnessen-Murray, a postdoctoral research fellow at James G. Jackson’s laboratory at the Tulane University School of Medicine, who led the research team, said.

Her team also discovered that senescent breast cancer cells frequently engulf neighboring cancer cells following exposure to doxorubicin or other chemotherapy drugs. Researchers observed this surprising behavior in cancer cells grown in the lab and also in tumors growing in mice.

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Chemotherapy is the treatment of cancer with drugs that can destroy cancer cells by impeding their growth and reproduction. At Cancer Treatment Centers of America (CTCA), we work closely with our patients to meet your individual needs before, during and after chemotherapy treatment.

Because cancer cells usually grow and divide faster than normal cells , chemotherapy has more of an effect on Chemotherapy is the use of drugs to destroy cancer cells . It usually works by keeping the cancer cells from Doctors use chemotherapy in different ways at different times. These include

They also found that lung and bone cancer cells are also capable of engulfing their neighbors after becoming senescent.

Tonnessen-Murray and her colleagues found that senescent cancer cells activate a group of genes, which are normally active in white blood cells, that engulf invading microbes or cellular debris. They saw that after “eating” their neighboring cancer cells, senescent cancer cells digested them by delivering them to lysosomes, which are acidic cellular structures highly active in senescent cells.

But the most important finding was that this process helps senescent cancer cells stay alive. Senescent cancer cells that engulfed neighboring cells survived in culture for longer than senescent cancer cells that didn’t.

Gallery: What chemotherapy is really like, according to cancer survivors (Reader's Digest)

Cancer Cells Devise Way To Survive Chemotherapy


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