Woman Gives Birth to Twins Nearly 3 Months Apart
Liliya Konovalova, 29, first gave birth to her daughter on May 24, and her son didn’t make his grand entrance until Aug. 9. A mom in Kazakhstan gave birth to twins 11 weeks apart after one was born prematurely. Liliya Konovalova, 29, first gave birth to her daughter on May 24, and her son didn’t make hi Doctors said the odds of this happening are just one in 50 million, according to the Ministry of Health of Kazakhstan Konovalova’s daughter, Liya, was born at only 25 weeks and weighed 1 pound, 13 ounces. More than two months later, baby boy Maxim arrived weighing 6 pounds, 6 ounces.
It ’ s just so special and worth it. Lance: The three years it took to get to where we are now felt like it was such a long journey, but everything was totally worth it. I was finally transplanted with a different donor’s uterus in 2017, and about three months after surgery, [the] doctors decided to do an embryo
The uterine transplant is the surgical procedure whereby a healthy uterus is transplanted into an organism of which the uterus is absent or diseased. As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation
This month, Kayla and Lance Edwards welcomed their daughter Indy Pearl Edwards into the world, and became the fourth couple to have a child through theat Baylor Scott & White Health’s Baylor University Medical Center.
The couple would have had a great love story even without those extraordinary circumstances. They attended elementary school together in Vancouver, Wash., lost touch, and then reconnected through social media more than a decade later. After months of chatting through the game “Words with Friends,” they finally went on a date in January 2013 and got engaged about a year later.
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“ It ’ s important to carry your own child and to feel that bond that you have when she’s in your stomach,” said the patient in an exclusive interview with The The mother would not say whether her donated uterus was removed. The birth of a second baby after a uterine transplant “is proof that this was
The woman is the second Baylor patient to give birth after receiving a uterine transplant from a living donor. She is the first to share her story publicly. Surgeons at Baylor have conducted eight uterine transplants —two from deceased and six from live donors—since launching their clinical trial in 2016.
Kayla always knew she wanted a family, but starting her own wasn’t easy. When she was 16 years old, she was diagnosed with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a congenital disorder that causes girls to be born either without or with an underdeveloped uterus. She stayed active in MRKH communities online, and eventually learned about a new option for women like her:. The first-ever birth from a transplanted uterus happened , the year the couple married. Baylor, one of the first U.S. institutions to perform the procedure, opened its clinical trial two years later, prompting Kayla, 28, and Lance, 27, to move to Dallas.
Baby Girl Born at Baylor Dallas Following Uterine Transplant
Baylor Dallas' uterine transplant clinical trial is the largest in the world
This was the first birth after a uterus transplant in the United States, at Baylor University Medical Center in Dallas.CreditCreditShannon A new frontier, uterus transplants are seen as a source of hope for women who cannot give birth because they were born without a uterus or had to have it
How a uterus transplant works. The women in the clinical trial are transplanted with a uterus from Baylor’s uterus transplant program is one of a handful to launch in the United States in recent years Like other infertility treatments, it ’ s very rare that an insurance company would cover the procedure
This is the couple’s story, lightly edited and condensed for clarity.
TIME: If you can put it into words, how are you feeling right now?
Kayla: It’s so rewarding to finally have her. We tried for so long, and there were some days when we thought it would never happen—especially being diagnosed with MRKH. To finally hold her and be like, ‘Oh my gosh, she’s here and she’s ours,’ has just been amazing. It’s just so special and worth it.
Lance: The three years it took to get to where we are now felt like it was such a long journey, but everything was totally worth it. I’m just soaking in every minute that I can. It’s like an out-of-body experience, to be honest.
Related video: Woman moves to North Texas for uterus transplant and then, good news (WFAA-TV Dallas-Ft. Worth)
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A woman recently gave birth after undergoing a uterus transplant from a deceased donor. Getty Images. In recent decades, physicians have made huge strides in helping women formerly considered infertile become pregnant with new drugs and procedures, like in vitro fertilization.
For the first time in the United States, a woman who was born without a uterus gave birth to a baby. The landmark birth took place at Baylor University
TIME: What was the process like, from transplantation to birth?
Kayla: It’s definitely been a long process—a little longer than some of the other girls in the program, just because we’ve had some hiccups. We moved in 2016, which is when were accepted into the trial. We had sold our house. We left everything we knew; we didn’t know anybody in Texas. Then when we got here, my donor actually fell through. I was a difficult blood match, so for the next year we waited to be matched again. That was really hard, to just sit here in Dallas be like, ‘Is this going to happen? Did we make the right choice?’
I was finally transplanted with a different donor’s uterus in 2017, and about three months after surgery, [the] doctors decided to do an embryo transfer. It didn’t work. They did another embryo transfer, and it didn’t work again. We did an IVF cycle and we got no eggs; my body didn’t respond to the medication. We had to go through another IVF cycle, and we only got two embryos. Then we did another embryo transfer, and it didn’t work. On the fourth transfer, our last embryo, they tried a natural cycle, which means they go off my natural menstrual cycle instead of mimicking it with medicine. It worked—which was really cool for a transplanted uterus, that it synched up to my body so well. My body knows what to do. I couldn’t believe when they told me that I was pregnant. It was surreal.
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The first woman in the United States gave birth to a baby after a uterus transplant . After undergoing multiple surgeries and taking powerful medication for the uterus transplant , the women Like other infertility treatments, it is uncommon that an insurance company would cover the cost of
It ' s an irreversible condition, called uterine factor infertility, affecting as many as 5% of women A 36-year-old woman gave birth after receiving a uterus transplant from a 61-year-old, unrelated donor. For a year after the transplant , the medical team checked to see how the recipient's body reacts to
Lance: I was getting to the point where I was like, ‘You know, maybe this isn’t the right thing for us to do,’ between the delays and the surgery and all the failed IVF cycles and watching my wife deal with the medications and hospital visits. Getting that phone call, it’s just like, ‘What? Are you kidding me? Did they triple check?’ Then it’s the worry of, ‘Is the pregnancy going to go well? Are we going to have a miscarriage?’ It’s a constant worry, almost from day one to the birth. But once you hold that baby and hear that cry, all of that goes out the window.
TIME: Was it strange to know your uterus came from a donor?
Kayla: Really, it’s been functioning so okay for me that I haven’t really thought of it as someone else’s. It’s just in there! You don’t really feel like, ‘Oh, I have a uterus today.’ Really, I’ve just been thankful for my donor. I really haven’t felt different, like there’s something foreign in me. This is what my body was intended to do, and I’m so thankful for this opportunity.
TIME: Have you met your donor?
Kayla: We have written letters to each other back and forth. She gave me a children’s book on the day Indy was born and wrote a sweet note in it. It made me cry.
Lance: I hope we can all meet the donor someday. We’re all so thankful. You can’t measure the amount of love that she has shown toward us, and the compassion. One day I just want to give her a big hug and tell her ‘thank you’ from the bottom of my heart.
TIME: How will you share this with Indy someday?
Lance: Definitely a lot of scrapbooks, a lot of news articles, videos and just showing our love.
TIME: Why did you choose to be so open with your story, when many couples who go through this experience are not?
Kayla: I’ve been open since the day we left Vancouver. I just hope our story gives people inspiration and hope. It is a taboo subject, and I want people to know there’s tons of support out there and people going through things with them. That has always has empowered me to share my story—so it could help somebody else.
First birth after uterus transplant from a deceased donor
In Brazil, a woman born without a uterus gave birth to a baby girl after receiving the uterus from a deceased donor.
For the first time, a woman gave birth to a child after receiving a uterus from a deceased patient. Until then, only uterine transplants from living donors had resulted in births. This new medical achievement, which took place in December 2017 in Brazil, was reported in detail on December 4 in. It is also the first birth allowed by a uterine transplant in Latin America.
The mother of the child was born without a uterus because of a rare congenital disease: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH). It affects about one woman out of 4500. For this Brazilian woman of 32 years, married for 5 years, there was a priori no other option than the adoption to become a mother ... Until doctors from the University Hospital of São Paulo offer him a uterine transplant. The organ came from a woman in a brain-dead state after bleeding. The latter, aged 45 and mother of three, also donated her heart, liver and kidneys.
An operation of more than 10 hours
The transplantation took place in September 2016, after a 10 and a half hours operation. Doctors reported that the uterus had remained close to 8 hours without blood supply after being taken, without affecting its functioning. The record was until then 3 hours and 25 minutes.
After the operation, the patient was immediately put on immunosupressors to prevent her body from rejecting the graft. After 37 days, the patient had her first menstrual period. And after six months, the doctors made a first attempt to transfer an embryo, previously obtained by in vitro fertilization, the only way to trigger a pregnancy in this case. But "the thickness of the endometrium does not reach the required 7 millimeters, we had to postpone the transfer of a cycle," say the doctors.
The second attempt, made a month later, was the right one. On December 15, 2017, after a normal pregnancy - and a month in advance - the patient gave birth by caesarean section to a healthy little girl weighing 2.55 kilos. The doctors took advantage of the delivery to remove the grafted uterus. Indeed, it was not intended to stay for life, only the time of pregnancy, to avoid any risk of rejection. By the time the Brazilian doctors wrote the study, seven months after giving birth, mother and child were doing well.
Proof of concept
Since, 39 transplants have been performed worldwide, resulting in 11 births. But until then, the organs came from live donors. This type of sampling is not without risk for the donors. Before the Brazilian experience, only a Turkish medical team had implanted a uterus taken from a deceased donor in 2011, without success.
Brazilian doctors now hope this case will inspire other teams. "The use of grafts of deceased patients could significantly expand access to this treatment," said Dr. Dani Ejzenberg, who led the operation. "The number of people wanting and committed to organ donation after death is much greater than that of living donors, offering a much larger potential donor population." In addition to women with MRKH syndrome, those who have had the uterus removed following cancer or haemorrhage from delivery may also benefit from this technique.
In France, the uterine transplant for pregnancy has been authorized since November 2015. However, this intervention is not routinely proposed, but in the context of clinical research. For the time being, two hospitals are authorized to practice it: the Limoges University Hospital (deceased donor collection) and the Foche Hospital (live donor).
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