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Health & Fit Triple Negative Breast Cancer: Everything You Need to Know

02:40  16 october  2019
02:40  16 october  2019 Source:   health.com

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We teach you why Triple Negative Breast Cancer is threatening. Learn how it is treated, and it's link to the BRCA genetic mutation. VISIT THE BREAST CANCER

Triple Negative Breast Cancer : What you need to know - Продолжительность: 10:06 Breast Cancer School for Patients 15 407 просмотров.

Not all breast cancers are the same. For people diagnosed with a type called triple negative breast cancer, that news can deliver an even bigger blow. Triple negative breast cancer is considered a more aggressive, harder-to-treat cancer—and this in turn affects survival rate and life expectancy.

Thanks to deeper research, experts have more knowledge about this form of breast cancer. That's helped doctors develop better ways to treat it, which has led to better outcomes for patients. Here's the latest information on the symptoms, risk factors, and treatment of triple negative breast cancer (TNBC).

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Only 10% to 20% of breast cancers are triple - negative , but they tend to be more aggressive. Laura Pearson, M.D, explains what you need to know about

Triple - negative breast cancer is an aggressive condition that is rarer than other types of breast cancer . It is more likely to come back than many In particular, around 70% of breast cancers in people with a BRCA gene mutation are triple - negative . If a doctor knows that a person has a family

What is triple negative breast cancer?

“Fifteen percent of breast cancers are triple negative,” Jane Mendez, MD, surgical oncologist and chief of breast surgery at Miami Cancer Institute, tells Health. The name refers to the tumor itself. “When we analyze [tumor] tissue, we can check for three receptors at the membrane of cancer cells to see which type of breast cancer the patient has,” she says.

These three receptors doctors check are for the hormones estrogen and progesterone, plus a protein called human epidermal growth factor—which is more commonly known as HER2, according to the Centers for Disease Control and Prevention (CDC).

Identifying these receptors is key, because it tells doctors which targeted therapies will be most effective in eradicating the cancer cells. However, the cancerous tumor or tumors in women who have been diagnosed with TNBC don't have any of these receptors. (Hence, the "triple negative" name.) That means there are far fewer options for targeted treatment.

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What is triple negative breast cancer ? Who is at risk? What Every Woman Needs to Know eBook. Triple negative breast cancer occurs in about 10-20% of diagnosed breast cancers and is more likely to affect younger people, African Americans, Hispanics, and/or those with a BRCA 1 gene

Your Breast Surgeon will know your “receptor pattern” within days after your initial breast biopsy. These results are often not communicated to you early on in your decision process. Triple Negative Breast Cancer : What you need to know - Продолжительность: 10:06 Breast Cancer School for

“When triple negative was first identified as a specific subtype, it was thought to be one disease lacking these three receptors. But with time and research, there has been an appreciation that within each [breast cancer] subtype there are more sub-subtypes,” Dorraya El-Ashry, PhD, chief scientific officer of the Breast Cancer Research Foundation (BCRF), tells Health. The future of TNBC is learning more about the biology of each subtype and using that info to better tailor treatment—and save more lives.

Triple negative breast cancer risk factors

TNBC occurs in approximately 10%-20% of breast cancer diagnoses, according to the National Breast Cancer Foundation. It is twice as common in black women as it is in white women in the US, according to the American Cancer Society. In the past, it was assumed that this discrepancy was due in part to socioeconomic factors. But researchers now believe that genetics play a role, says Dr. Mendez.

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Triple negative breast cancer is also more common in premenopausal women. In addition, about 75% of TNBC cases are in people who have the BRCA1 mutation (a genetic mutation that increases one’s risk of developing breast and ovarian cancers).

Triple negative breast cancer treatment

“[Targeted treatment for TNBC] is considered the holy grail in breast cancer because we don’t have the magic bullet as we do with other breast cancers,” says Dr. Mendez. That makes TNBC a lot more difficult to treat. Besides the fact that researchers haven’t identified the right therapies, this kind of tumor couldbe more biologically aggressive, she adds.

That said, catching it early is the goal. “TRBC has a higher likelihood of metastasis [spreading to distant sites in the body], and therefore has a poorer outcome,” says El Ashry.

Current treatment options for TNBC include surgery (lumpectomy or mastectomy), chemotherapy, and radiation, says Dr. Mendez. Unfortunately, the downside of using chemo to treat TNBC is that the cancer becomes resistant to chemo quicker than it does with other types of breast cancer, adds El Ashry.

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Triple - negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer . Often, patients first need to have the lump removed (a lumpectomy) or the entire breast removed (a mastectomy). Then they have chemotherapy treatments

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There is hope though: New drugs are becoming available, and immunotherapy to treat TRBC is in clinical trials. The right treatment for each woman depends on the size of the tumor, the stage of the cancer (for example, if lymph nodes are involved), and personal health history—plus the results of genetic testing.

If you are under age 65, doctors will refer you for genetic counseling to identify the presence of a BRCA mutation, says Dr. Mendez. Treatment depends on the outcome of testing:

If you do have a BRCA 1 or 2 mutation: Doctors may recommend a bilateral mastectomy followed by reconstruction. Because of the presence of this mutation, “we know that it’s a matter of time that you’ll likely develop breast cancer in the other breast,” says Dr. Mendez.

One bright spot if you have the BRCA mutation: You may be a candidate for a PARP inhibitor, a type of targeted therapy. One is a drug called talazoparib, approved by the FDA in 2018 for patients with locally advanced or metastatic breast cancer who are HER2-negative and have a BRCA1 or 2 mutation. “Originally it was identified as a therapy for ovarian cancer, but has been shown effective in this type of cancer,” says El-Ashry.

If you don’t carry a BRCA mutation: then surgery, systemic chemotherapy (chemo that travels in the bloodstream), neoadjuvant chemotherapy (chemo before surgery), and radiation are all options, says Dr. Mendez. “Not all patients receive all treatments,” she says.

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What You Can Do and The Breast Cancer Site team up for Interviews with Breast Cancer In this video, Jacqueline Peterson, a Breast Cancer survivor, explains triple negative breast cancer , one of Triple - negative breast cancers , everything you 've always wanted to know | ECP Symposium

After a diagnosis of triple - negative breast cancer , you may be searching for information or For more information, visit the Triple - Negative Breast Cancer pages on the main Breastcancer .org Before I do any treatment, I need to know that it is likely to have a meaningful result on my survival chances.

The catch with triple negative breast cancer is that there are 70 subtypes. That may explain why some patients have a lot of success with standard treatment, while others are resistant to these efforts.

Still, women with TNBC should not lose hope. “While this is the [breast cancer] subtype we know the least about in terms of having targeted therapies, it’s not brand new, and there are large clinical trials in cancer centers and community hospitals that may be available to you,” says El Ashry.

If you are diagnosed with TNBC, don’t hesitate to get a second opinion, so you can make sure you're getting what you feel is the best treatment plan for you. “With research, we’re just starting to break the code of triple negative breast cancer,” she says.

Gallery: 6 Cancers on the Rise in Older Adults (Provided by Insider)

   Although the overall cancer rate in the   United States has been in decline since the 1990s, certain types   of cancers are becoming increasingly common, especially in older   adults. Those linked to obesity, such as liver and pancreatic   cancer, are among the fastest-growing.            People are more at risk of cancer as they age because of a     decline in their immune systems, lifestyle factors like diet     and alcohol/tobacco use, and treatment of other chronic     illnesses.      Here are some of the types of cancer on the rise in older   adults, factors that may be contributing to the increase, and   what you can do to reduce your risk.                   Visit INSIDER's     homepage for more stories.       Age is still the   number one risk factor for developing cancer.    And as the older population in the US increases, the number of   new cancer cases are expected to rise by as much as 2.1 million   by 2030, even as overall cancer rates are declining in the US,   according to the    Centers for Disease Control and Prevention (CDC).    More than 60% of all new cancer diagnoses are in people aged 60   and older, according to the CDC. Older men are more at risk of   some of the more prevalent types of cancer, such as liver cancer.   But older women continue to be at the highest risk of breast   cancer.     Here are some of the most common types of cancer that are on the   rise in older adults, and some of the risk factors contributing   to the increase.           Read more:        Experts warn we're not ready for the 'silver tsunami' of older   adults living with cancer

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