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Health & Fit Can Fungi In The Gut Cause Pancreatic Cancer?

08:15  25 october  2019
08:15  25 october  2019 Source:   medicaldaily.com

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The fungi that inhabit the body and their effect on human health have not received as much attention from scientists as bacteria. This situation could be about to change as a new study reveals that fungi that live in the gut appear to have a role in pancreatic cancer .

Pancreatic cancer accounts for 3 percent of all cancers in the United States. Tumors of the pancreas cancers are usually too small to cause symptoms, and later Fungi from the gut can promote cancer in the pancreas . Deleting just one gene may 'completely prevent' pancreatic cancer .

Only 9.3 percent of people diagnosed with pancreatic cancer made it past the remission period between 2009 and 2015, according to the National Cancer Institute (NCI). Researchers at New York University School of Medicine recently made some headway into the treatment of one of the top 10 most common cancers that is estimated to be diagnosed in 55,770 people in 2019.

  Can Fungi In The Gut Cause Pancreatic Cancer? © svetikd/Getty Images

They studied the fungal microbiome, specifically the way certain species could cause pancreatic cancer, in a paper published in the journal Nature on October 2. Previously, bacteria and fungi were linked to colon and liver cancer. In a major breakthrough, researchers have observed a connection to pancreatic cancer for the first time, although the hypothesis is not new and was not well recieved before.

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Pancreatic cancer often goes undetected until it's advanced and difficult to treat. In the vast majority of cases, symptoms only develop after pancreatic By the time it's large enough to cause symptoms, pancreatic cancer has generally grown outside the pancreas . Because of the location of the

Research shows fungi can migrate from your gut to your pancreas , where it can contribute to the development of pancreatic cancer . The fungi trapped in the pancreas appears to drive tumor growth by activating MBL (mannose-binding lectin), a liver protein that triggers an immune mechanism

The paper described how fungi travel from the gut in the opposite direction of digestive juices and reach the pancreatic duct. This is also the tube used by the pancreas to transport digestive juices to the intestine.

Pancreatic ductal adenocarcinoma (PDA) is one of three types of pancreatic cancers, and make up about 90 percent of all pancreatic cancer cases. Regarding the cancer and the multiplication of the fungi, the study stated “PDA tumors in humans and mouse models of this cancer displayed an increase in fungi of about 3,000-fold compared to normal pancreatic tissue."

“While past studies from our group have shown that bacteria travel from the gut to the pancreas, our new study is the first to confirm that fungi too make that trip, and that related fungal population changes promote tumor inception and growth,” senior study co-author George Miller said in the news release.

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Pancreatic cancer arises when cells in the pancreas , a glandular organ behind the stomach, begin to multiply out of control and form a mass.

Diagnosing pancreatic cancer early could help fast-track a person's access to adequate treatment and boost the likelihood of a positive outcome. Existing studies have already suggested that there is a connection between pancreatic health and bacterial abundance in the gut and that the

Experiment Conducted On Mice

Over a period of 30 weeks, glowing fluorescent proteins were attached to the fungi to follow the route they took from the gut to the pancreatic duct within the mice studied. Genomic and statistical methods were employed by the researchers to study the different kinds of fungi and the rate of various fungi populations' proliferation.

Significant differences were observed between the fungi found in the cancerous pancreas and healthy pancreas in mice and human tissue samples as well.  Among all the fungal species, the Malassezia species were present abundantly inside cancerous tissues, especially in comparison to other fungal species such as Parastagonospora, Saccharomyces and Septoriella. The other species also grew at a slower rate.

The Malassezia genome sped up the growth of cancer by 20 percent, the researchers found. This does not happen in the presence of other fungi species along with it, according to a report by Medical News Today. Since the cause was identified, they were able to figure out which antifungal medicine is suited to bring down the tumor. The antifungal drug the researchers found to reduce the tumors weight by 20 to 40 percent is called amphotericin B.

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These gene changes may cause as many as 10% of pancreatic cancers . Sometimes these changes result in syndromes that include increased risks of other Lucenteforte E, La Vecchia C, Silverman D, et al. Alcohol consumption and pancreatic cancer : A pooled analysis in the International Pancreatic

Early pancreatic cancers often do not cause any signs or symptoms. By the time they do cause symptoms, they have often grown very large or Cancers that start in the head of the pancreas are near the common bile duct. These cancers can press on the duct and cause jaundice while they are

The drug coincedentally had more than one use. It also helped treat the early stage of pancreatic cancer and reduced it by 20 to 30 percent. Similarly, the treatment also aided the performance of the chemotherapy drug used to treat pancreatic cancer.

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What Is Pancreatic Cancer? .
Some growths in the pancreas are simply benign, while others might become cancer over time if left untreated.Pancreatic adenocarcinoma is the most common type of pancreatic cancer. Pancreatic neuroendocrine tumors (NETs) are a less common type and are discussed in Pancreatic Neuroendocrine Tumors.

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