Health & Fit Covid-19: after "promising" trials, Sanofi offers 300,000 doses of antimalarials to treat patients

10:40  18 march  2020
10:40  18 march  2020 Source:   leparisien.fr

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Clinical trials on 24 coronavirus patients were " promising " and would be extended to more patients . 6 days after the start of taking Plaquenil, the virus had Sanofi said it could offer enough doses of Plaquenil - a drug containing the molecule hydroxychloroquine - to treat up to 300 , 000 people.

French pharmaceutical giant # Sanofi said it was ready to offer France millions of doses of anti-malaria treatment called Plaquenil, that early PagesMediaBooks and magazinesNewspaperDaily News EgyptVideosSanofi offers anti-malaria medicine to COVID - 19 patients , after promising trials .

The results of tests carried out on patients with coronavirus with this treatment are considered encouraging.

Le Parisien © AFP / Gérard Julien Le Parisien

As echoing the statements of French government spokeswoman Sibeth Ndiaye, who said on Tuesday that clinical trials were "promising" and would be extended to more patients, the French laboratory Sanofi has said it is ready to offer the French authorities millions of doses of the antimalarial Plaquenil. This drug could potentially treat 300,000 patients with Covid-19.

In view of a study with encouraging results conducted on this drug, "Sanofi is committed to making its treatment available to France and to offering several million doses that could treat 300,000 patients," said Tuesday. a spokesperson for the laboratory, while specifying that the group was ready to work with French health authorities "to confirm these results".

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Both drugs are approved to treat malaria, lupus and rheumatoid arthritis, but must still be assessed in clinical trials before being declared a safe and effective COVID - 19 treatment . "We understand and recognize the urgency with which we are all seeking prevention and treatment options for COVID - 19 .

Patients received a single dose of 400 mg tocilizumab via intravenous infusion. In general, the patients improved with lower oxygen requirements, lymphocyte counts returned to normal, and 19 ARDS/lung injury. Dry powder inhaled formulation with potential to treat ARDS caused by COVID - 19 .

Three-quarters of people treated cured

Plaquenil, a molecule of hydroxychloroquine, also used for decades in autoimmune diseases like lupus or rheumatoid arthritis, could indeed have an effect on the disappearance of the virus, said Monday Professor Didier Raoult, director of the Institut Hospitalo-Universitaire de Marseille.

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According to this study carried out by Professor Raoult on 24 patients suffering from the coronavirus, six days after starting to take Plaquenil, the virus had disappeared in three quarters of the people treated.

These new clinical trials "will be carried out with a team independent of Professor (Didier) Raoult", specified Sibeth Ndiaye after a Council of Ministers, stressing that at this stage "we have no evidence scientific "that this treatment works. Several experts call for caution in the absence of further studies and because of the side effects which can be serious, especially in the event of an overdose.

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on COVID - 19 treatment (14), 100% of patients treated with. Clinical trials . have demonstrated promising data on mortality improvement. in sepsis, but more extensive studies are and safety of thalidomide combined with low- dose hormones in the. treatment of severe Covid - 19 . Conclusions: In hospitalized adult patients with severe Covid - 19 , no benefit was observed with lopinavir-ritonavir

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"I have taken note of the results and have given the authorization so that a larger trial by other teams can be undertaken as soon as possible on a larger number of patients", de his side indicated during a telephone press conference the Minister of Health Olivier Véran.

Donations of hydroalcoholic gel

The latter expressed the hope that these new tests would "consolidate the interesting results" obtained by Professor Raoult. But "it is absolutely fundamental to base any decision of public health policy on validated scientific data, and the validation processes, one cannot negotiate with", he underlined about these tests.

Business initiatives are multiplying in the face of the pandemic. Last Friday, Sanofi, which is working on a vaccine against the new coronavirus, had already announced the creation of a seed fund to support the research effort of the teams of the Assistance Publique Hôpitaux de Paris (AP-HP) in their fight against the coronavirus.

Sunday, the luxury group LVMH also said it would act by announcing that its fragrance branch was going to manufacture hydroalcoholic gels made available free of charge to French health authorities.

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