Health & Fit Antibiotic resistance: a natural compound in green tea would help fight it

05:20  26 september  2019
05:20  26 september  2019 Source:   medisite.fr

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Antibiorésistance : un composé naturel du thé vert aiderait à la combattre © Medisite Antibiotic resistance: a natural compound in green tea would help fight it

Antibiotic resistant bacteria are a real threat to global health. In the next 30 years, the number of people who die from it could rise to 10 million. Researchers have just discovered a promising new avenue to combat them. By combining a polyphenol found in green tea with an antibiotic, they have overcome one of these superbugs.

700,000 people die each year from infections caused by resistant bacteria , according to figures from Inserm. Over the next 30 years, that number could rise to 10 million . Researchers have therefore already started to address the question of antimicrobial resistance, with the aim of finding more effective treatments. For certain infections, the answer may well be found ... in tea !

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A study, published in the Journal of Medical Microbiology, found that epigallocatechin (EGCG), a polyphenol extracted from green tea leaves, would help fight a superbug, when combined with an antibiotic.

Resistant to antibiotics, the bacteria P. aeruginosa is increasingly difficult to treat

More specifically, scientists from the University of Surrey, in England, studied the bacteria Pseudomonas aeruginosa , responsible for serious infections , or even fatal . This microorganism is particularly prevalent in hospitals, and can infect patients with weakened immune systems. It is thought to cause more than 8% of nosocomial diseases , and is resistant to many classes of antibiotics.

Currently, doctors are using a combination of several antibiotics to treat P. aeruginosa infections, but these are becoming more and more difficult to treat, because there is resistance to last-line antibiotics.

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A component of green tea would make antibiotics more effective against the bacteria

In this study, the researchers found that by combining epigallocatechin with aztreonam , an antibiotic authorized on the market and frequently used to fight these infections, the results were much more conclusive. The antioxidant extracted from green tea appears to restore the activity of the drug, and make it more effective against superbug.

Scientists believe that EGCG could facilitate the absorption of aztreonam by the bacteria, by increasing the permeability of the bacteria. Another explanation could be the interference of EGCG with a biochemical pathway related to antibiotic sensitivity.

In vitro tests have confirmed the effectiveness of this combination

To study this synergy between epigallocatechin and aztreonam, and the way they interact with P. aeruginosa, the researchers conducted in vitro tests on caterpillars, then on human skin cells.

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Result: survival rates were higher in caterpillars treated with the combination of EGCG and aztreonam, than in those treated with only one of these molecules. In addition, toxicity minimal, or even zero, was observed in the skin cells and in the caterpillars having received this combination.

In other words, this association was significantly more effective for in reducing the number of P. aeruginosa, than either agent alone.

A promising new avenue in the fight against antimicrobial resistance

For the researchers, the results of this study could open a new avenue in the fight against the superbugs . "Antimicrobial resistance is a serious threat to global public health," said Dr. Jonathan Betts, senior researcher at the University of Surrey's faculty of veterinary medicine.

“We urgently need to develop new antibiotics in the fight against this resistance. Natural products, such as EGCG, used in combination with approved antibiotics, can be one way to improve their efficacy and their clinical useful life, "he said.

Combine natural products and antibiotics to save humanity?

Prof. Roberto La Ragione, head of the department of pathology and infectious diseases of the faculty, adds that “the World Health Organization has classified the antibiotic resistant Pseudomonas aeruginosa as one of the critical threats to human health . We have shown that can effectively eliminate from this type of threat by using natural products, combined with antibiotics already used ”.

The researcher considers that these alternatives to antibiotics deserve to be developed, so as to allow their future use in the clinical field.

Drug-resistant superbugs kill someone every 15 minutes in the US, new CDC report reveals .
Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention. © Centers for Disease Control Clostridioides difficile or C. Diff is a bacteria that causes diarrhea and inflammation of the colon. Every year there 223,900 cases of infection and 12,800 deaths from the bacteria. The pathogen is listed as one of the CDC's five urgent threats to antibiotic resistance. © Courtesy the Lillis family Peggy Liliis and her sons, Christian and Liam.

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This is interesting!