Health & Fit Antibiotic resistance: a natural compound in green tea would help fight it

05:20  26 september  2019
05:20  26 september  2019 Source:   medisite.fr

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An ingredient commonly found in green tea could help eliminate antibiotic resistant bacteria - one Researchers at the UK’s University of Surrey found that a natural antioxidant in green tea can help aztreonam, an antibiotic commonly used to treat serious respiratory tract and bloodstream infections.

Green tea has gained immense popularity across the globe, mainly because of its health benefits. A team of researchers at the University of Surrey has found that a natural antioxidant, called epigallocatechin (EGCG), which is commonly found in green tea can help fight antibiotic - resistant bacteria. Natural products such as EGCG, used in combination with currently licensed antibiotics

Antibiorésistance : un composé naturel du thé vert aiderait à la combattre © Medisite Antibiotic resistance: a natural compound in green tea would help fight it

Antibiotic resistant bacteria are a real threat to global health. In the next 30 years, the number of people who die from it could rise to 10 million. Researchers have just discovered a promising new avenue to combat them. By combining a polyphenol found in green tea with an antibiotic, they have overcome one of these superbugs.

700,000 people die each year from infections caused by resistant bacteria , according to figures from Inserm. Over the next 30 years, that number could rise to 10 million . Researchers have therefore already started to address the question of antimicrobial resistance, with the aim of finding more effective treatments. For certain infections, the answer may well be found ... in tea !

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As the antibiotic resistance crisis deepens, experts are looking for new angles. A new study concludes that a compound found in green tea could be Antibiotic resistant bacteria are one of the biggest threats to global health. As researchers scramble to find solutions, a recent study concludes that a

(Related: Beat interstitial cystitis naturally .) Green tea is a powerful aid for beating cystitis. Stay informed and you'll even likely learn information that may help save your own life." Women in the green tea group showed a statistically significant decrease in the prevalence of cystitis symptoms at

A study, published in the Journal of Medical Microbiology, found that epigallocatechin (EGCG), a polyphenol extracted from green tea leaves, would help fight a superbug, when combined with an antibiotic.

Resistant to antibiotics, the bacteria P. aeruginosa is increasingly difficult to treat

More specifically, scientists from the University of Surrey, in England, studied the bacteria Pseudomonas aeruginosa , responsible for serious infections , or even fatal . This microorganism is particularly prevalent in hospitals, and can infect patients with weakened immune systems. It is thought to cause more than 8% of nosocomial diseases , and is resistant to many classes of antibiotics.

Currently, doctors are using a combination of several antibiotics to treat P. aeruginosa infections, but these are becoming more and more difficult to treat, because there is resistance to last-line antibiotics.

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Scientists have discovered that a natural antioxidant commonly found in green tea can help eliminate antibiotic resistant bacteria. We urgently need to develop novel antibiotics in the fight against AMR. Natural products such as EGCG, used in combination with currently licenced antibiotics , may

The important components in green tea that show antimicrobial properties are the catechins. The CDC has estimated that each year more than two million people in the US suffer from antibiotic - resistant infections and that as many as 23,000 people die each year from these infections

A component of green tea would make antibiotics more effective against the bacteria

In this study, the researchers found that by combining epigallocatechin with aztreonam , an antibiotic authorized on the market and frequently used to fight these infections, the results were much more conclusive. The antioxidant extracted from green tea appears to restore the activity of the drug, and make it more effective against superbug.

Scientists believe that EGCG could facilitate the absorption of aztreonam by the bacteria, by increasing the permeability of the bacteria. Another explanation could be the interference of EGCG with a biochemical pathway related to antibiotic sensitivity.

In vitro tests have confirmed the effectiveness of this combination

To study this synergy between epigallocatechin and aztreonam, and the way they interact with P. aeruginosa, the researchers conducted in vitro tests on caterpillars, then on human skin cells.

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To brew green tea , steep a tea bag or loose tea leaves in a tea infuser for five minutes. Matcha powder is finely ground green tea leaves, and In addition, compounds in green tea can interact with certain medications, including acetaminophen, codeine, verapamil, nadolol, tamoxifen, and bortezomib, so

Green Tea Benefits - A Big Boost in Antibiotic Effectiveness. As more people become increasingly Cephalosporin, an important antibiotic in the treatment of resistant bacteria st rains, showed a 20 The EGCG compound in black and oolong teas is converted because the tea leaves a re fermented.

Result: survival rates were higher in caterpillars treated with the combination of EGCG and aztreonam, than in those treated with only one of these molecules. In addition, toxicity minimal, or even zero, was observed in the skin cells and in the caterpillars having received this combination.

In other words, this association was significantly more effective for in reducing the number of P. aeruginosa, than either agent alone.

A promising new avenue in the fight against antimicrobial resistance

For the researchers, the results of this study could open a new avenue in the fight against the superbugs . "Antimicrobial resistance is a serious threat to global public health," said Dr. Jonathan Betts, senior researcher at the University of Surrey's faculty of veterinary medicine.

“We urgently need to develop new antibiotics in the fight against this resistance. Natural products, such as EGCG, used in combination with approved antibiotics, can be one way to improve their efficacy and their clinical useful life, "he said.

Combine natural products and antibiotics to save humanity?

Prof. Roberto La Ragione, head of the department of pathology and infectious diseases of the faculty, adds that “the World Health Organization has classified the antibiotic resistant Pseudomonas aeruginosa as one of the critical threats to human health . We have shown that can effectively eliminate from this type of threat by using natural products, combined with antibiotics already used ”.

The researcher considers that these alternatives to antibiotics deserve to be developed, so as to allow their future use in the clinical field.

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