Health & Fit Promising patch against food allergies

16:57  10 march  2017
16:57  10 march  2017 Source:   msn.com

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The French biotech firm DBV Technologies has developed the first patch effective against peanut allergy , according to the latest results of a clinical study presented this weekend in the United States, a very promising approach against d other food allergens .

Is food the cure for a food allergy ? The results showed that participants who received higher doses of peanut protein in the patch were able to consume more peanuts after a year. The patch was the most effective on children ages 4 to 11 and significantly less effective on older participants, according to a statement from the National Institutes of Health, which funded the study through its Dr. Jennifer Shih, an assistant professor at Emory University School of Medicine who specializes in pediatric allergies , said the peanut patch study is promising , but it doesn't mean an end to peanut allergy problems.

Environ 2% des enfants sont allergiques aux cacahuètes aux Etats-Unis, allergie alimentaire la plus fréquente dans ce pays © Provided by AFP About 2% of children are allergic to peanuts in the United States, the most common food allergy in this country

The French biotechnology company DBV Technologies has developed the first patch effective against peanut allergy, according to the final results of a clinical study presented this weekend in the United States, an approach also very promising against other food allergens.

This epidermal patch called Viaskin made it possible to reduce by 98% the risk of exacerbated allergic shock which can be fatal, shows a follow-up to this study conducted for three years in a group of patients from 4 to 11 years old.

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Buffer Against Reactions. The patch therapy’s goal is desensitization, or increasing an allergic child’s threshold for consuming peanut before experiencing symptoms of an allergic reaction. The nonprofit FARE ( Food Allergy Research and Education) expressed disappointment with the FDA’s decision to not approve the current Viaskin therapy, but also held out hope for a revised Viaskin design. “We are confident that the concerns raised by the FDA can be addressed and that this development will lead to an improved version of the patch ,” said FARE CEO Lisa Gable.

Food allergies and other types of food hypersensitivities affect millions of Americans and their families. Food allergies occur when the body's immune system reacts to certain proteins in food . Food allergic reactions vary in severity from mild symptoms involving hives and lip swelling to severe, life-threatening symptoms, often called While promising prevention and therapeutic strategies are being developed, food allergies currently cannot be cured. Early recognition and learning how to manage food allergies , including which foods to avoid, are important measures to prevent serious health consequences.

It is estimated that 2% of children are allergic to peanuts in the United States, the most common food allergy in this country where the population is fond of this food. And their number has increased by 50% since the late 1990s, determined the American Centers for Disease Control and Prevention (CDC).

In France, the prevalence of this allergy represents 0.3% to 0.75% of the population.

"These results are extremely encouraging" since 83.3% of the participants were able to multiply the quantity of peanuts they could consume, said Dr. Pierre-Henri Benhamou, co-founder and CEO of DBV Technologies, in a telephone interview with AFP.

"This is the first desensitization and healing patch for a food allergy," he noted, saying that before "there was no real treatment for this type of allergen".

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Food allergies are immunologically mediated adverse reactions to foods . Any food protein can trigger an allergic response, and allergic reactions to a large number of foods have been documented; however, only a small group of foods account for most of these reactions. Prick testing: This is the most common screening test for food allergy ; negative predictive accuracy exceeds positive predictive accuracy (>90% vs < 50%). Intradermal testing: Generally avoided, because of the risk of inducing a systemic reaction. Patch testing: Appears promising , but additional studies are needed and it is not

Promising trial shows band-aid style device cured 50% of volunteers. Device tested by National Institutes of Health is showing promising results. After a year of clinical trials, 50% of peanut- allergic volunteers are cured. It is particularly effective in under 12-year-olds, researchers said. A skin patch has been developed to treat peanut allergies . The device, being tested by the National Institutes of Health, delivers small amounts of peanut protein through the skin to build up sufferers' immunity.

- Therapeutic breakthrough -

The Food and Drug Administration (FDA), the American food and pharmaceutical agency, granted therapeutic breakthrough status to this patch, paving the way for an accelerated marketing authorization process , maybe as early as 2018.

This patch is based on a discovery showing that it is possible to act on the immune system through the skin.

The patch contains a very concentrated extract of peanut protein, 250 micrograms, which is diffused in the epidermis without passing into the blood, avoiding the risk of allergic shock for the patient while gradually desensitizing it.

"The goal is not to be able to eat a bunch of peanuts but to reduce the sensitivity enough to avoid a potentially fatal reaction in case of accidental consumption of peanuts in a sauce or a dish," explained Dr. Benhamou, who clarified that the severe allergy to this food is responsible for several thousand anaphylactic shocks per year in the United States of which 150 are fatal.

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Promise Rings. Peanut Allergy \ Food Allergy Alert Patch | Allergic to Peanuts Medical Alert patches for School Backpack Pouch Jacket Bag.

The latest in promising food allergy research and clinical trials. Microbiome. Toxic Correlations. Gut Microbes May Be Key to Solving Food Allergies . New therapeutics are testing whether protective bacteria can dampen harmful immune responses to food . Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring.

Researchers who carried out the phase 2 clinical trial, including a follow-up of several months with 28 children from 4 to 11 years old, presented the final data on Sunday at the Congress of the American Academy of Allergy, Asthma and Immunology gathered in Atlanta (Georgia).

These data represent three years of study, ie the total duration of the treatment which consists in wearing the patch permanently and changing it every day.

- Potential blockbuster -

The results of the phase 3 clinical trial, the last stage before commercialization, will be known in autumn 2017, said Dr Benhamou. According to him, this treatment would represent a market of about a billion and a half dollars. "This patch has blockbuster potential," he said.

The market for the treatment of food allergies is even more extensive since it is estimated that between 6 and 8% of the population in Europe and the USA suffers from it. The proportions are probably of the same order in China and Japan, according to the CEO of DBV Technologies.

Thus an allergy to milk affects 2% of children and 1% of adults, he added, also citing allergens in eggs, wheat, soy and seafood.

For dairy products, the French firm has developed a patch already tested in a phase 2 clinical trial in children whose results are similar to those obtained for peanuts and is preparing a desensitization patch to the allergen in the egg which poses problems especially in populations in Asia.

Another approach to avoiding peanut allergies is to have foods containing them at an early age.

In January, the National Institute of Allergies and Infectious Diseases (NIAID) recommended that peanuts be consumed regularly by children from the age of four months and up to five years.

A study carried out by this same institute showed that this made it possible to reduce by 81% the rate of allergy in children.

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This is interesting!