Health & Fit Roche Drug Reduces Need for Ventilation in Covid Patients
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Fast fashion is getting cheaper while luxury gets more expensive—so what’s the “right” price for clothes? Much of it comes down to fabric quality, ethical labor, and profit margins. Here, two designers explain what you’re really paying for.Read that again, and the idea of a T-shirt being “worth” $5 might seem preposterous, if not criminal. How is it possible that all of those materials, logistics, and people amount to just dollars or cents? Many of those costs are fixed; the price of cotton isn’t negotiable, even at scale. The person who made the T-shirt, on the other hand, is a lot easier to exploit.
(Bloomberg) -- Roche Holding AG said its Actemra drug reduced the need for ventilation in a third-phase clinical trial on hospitalized patients with Covid-19 and pneumonia.
The patients who got the drug were 44% less likely to progress to ventilators or die, compared with others who just got the standard care, Roche said Friday. There was no statistically significant improvement in reducing mortality in the results published Friday.
Hospitals are running out of staff, supplies, and beds for Covid-19 patients — and this time could be worse
If hospitalizations continue to rise, health care workers in Arizona, Texas, and California fear they’ll be completely overwhelmed.Hospitals in hot spots across the country are expanding and even maxing out their staff, equipment, and beds, with doctors warning that the worst-case scenario of hospital resources being overwhelmed is on the horizon if their states don’t get better control of the coronavirus.
In August, results from anotheron Actemra showed that injecting the medicine didn’t help improve the health of patients or reduce deaths, although it did appear to allow people to leave the hospital earlier.
What Bloomberg Intelligence Says
“Roche’s Empacta trial in hospitalized Covid-19 patients showed a significant reduction in ventilator need, but not death, which is perplexing given subjects needing ventilation have a higher mortality rate.”
-- Sam Fazeli, pharma analyst
Roche Actemra Covid-19 Win Leaves Several Open Questions: React
The Roche study is one of many programs to evaluate known treatments -- from antiviral drugs to plasma from recovered patients -- against the pandemic virus.
Actemra and other medicines with the same mode of action such as Regeneron Pharmaceuticals Inc. and Sanofi’s Kevzara spurred hope against Covid-19 because they work on inflammation, which the new virus appears to stoke in many patients.
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Young people have reported higher levels of anxiety and depression during the pandemic, according to a new survey.Ever since COVID-19 reared its ugly head and upended our world, long-lasting symptoms of the virus have been varied and hard to pinpoint—until now. "A survey conducted by Dr. Natalie Lambert of Indiana University School of Medicine and Survivor Corps analyzed the long-term experiences COVID-19 survivors are having with the virus. The COVID-19 'Long Hauler' Symptoms Survey Report identified 98 long-lasting symptoms." Click through from least common to most common to see if you've experienced any.
Unlike antivirals, these drugs won’t attack the virus directly, but instead are thought to have an effect on the immune system’s response to the pathogen. The idea is to prevent the massive reaction that chokes the lungs of the sickest patients.
Actemra’s sales surged 36% in the first half of the year, a gain fueled in part by its use in Covid-19 patients.
The test was Roche’s first with a focus on enrolling primarily minority patients. About 85% of the 389 patients were of ethnic groups including Hispanic, Native American or Black.
Roche is also studying the drug in combination with an antiviral. No health authority has yet approved Actemra for Covid-associated pneumonia.
(Updates with previous trial in third paragraph)
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Video: Out of 8 companies, just 3 vaccines are in final stage of trials (ABC News)
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