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Health & Fit Menopause: the hormonal treatment responsible for an increased risk of breast cancer?

10:25  05 january  2021
10:25  05 january  2021 Source:   medisite.fr

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Treating menopausal symptoms with estrogen and progestin together is known as estrogen-progestin therapy (EPT) or combined hormone therapy. This analysis found that women who took estrogen and progestin (progesterone) after menopause did have an increased risk of getting ovarian cancer .

HRT for menopause 'raises breast cancer risk to double previous estimates'Credit: Getty - Contributor. It means HRT is to blame for one in 20 “It’s going to be responsible for more than five per cent of all breast cancers .” The average age for menopause in the UK is 51, with common

Ménopause : le traitement hormonal responsable d'une hausse du risque de cancer du sein ? © Adobe Stock Menopause: hormone therapy responsible for increased risk of breast cancer?

While a 2019 study revealed that treatments against menopause increase the risk of breast cancer, even after stopping them, a gynecologist-endocrinologist tends to put this risk into perspective and recommends treatment on a case-by-case basis depending on the initial risk patients.

"There is a risk, but it is modest" , assures this January 2 in Top Health Professor Anne Gompel, gynecologist-endocrinologist at Cochin hospital and president of the National College of Teachers of Medical Gynecology. More than a year ago, a study published on August 29, 2019 in the British journal The Lancet confirmed that hormonal treatments for menopause increase the risk of breast cancer.

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Some breast cancer treatments can bring on menopause more abruptly than it would happen otherwise. Again, this is called medical This can be due to a strong family history of these diseases or a positive test for a genetic abnormality that increases risk (such as BRCA 1 or BRCA 2).

Menopausal hormone therapy (MHT)—also called postmenopausal hormone therapy and hormone replacement therapy—is a treatment that doctors However, studies of MHT use in breast cancer survivors have produced conflicting results, with some studies showing an increased risk of breast

We learned that the risk of breast cancer persists for up to 20 years after stopping the drugs . The longer the treatment, the greater the risk. According to the study, a fifty-year-old woman who undergoes menopause treatment combining estrogen and progesterone for five years has an 8.3% probability of developing breast cancer within 20 years following treatment. .

"4 additional cases of cancer per 1,000 women"

"In a recent study, we show that for women at low initial risk, hormonal treatment of menopause causes 4 additional cases of cancer per 1,000 women treated for 7 , 5 years . It is not nothing, but it remains moderate , the more so as there are benefits to be put in the balance ", answers for her part the gynecologist Anne Gompel. According to her, "everything therefore depends on the initial risk, because multiplying by 1.3 a low risk is not the same thing as multiplying by the same ratio a significant basis risk".

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The known risk factors for breast cancer are listed below. Click on each link to learn more about the risk Being overweight also can increase the risk of the breast cancer coming back (recurrence) in women Almost all breast cancer treatments have varying degrees of risk for nausea and vomiting.

An increased risk of breast and cervical cancer seen in current and recent users appeared to be lost within about five years of stopping oral contraception, with no BACKGROUND The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed the worldwide

Anne Gompel therefore recommends treatment on a case-by-case basis depending on the profile of patient . "The idea is to select the patients who are offered this treatment on the basis of their initial risk. And above all, to change the outlook on the menopause consultation. This can be an opportunity to help women. to take advantage of this moment to restore order in their hygiene of life and thus reduce their risk of breast cancer ", she explains in Top Health.

Establish a "benefit-risk balance"

For patients who present risks, the gynecologist-endocrinologist establishes a "benefit-risk balance" . "The most complicated, it is the women who have had breast cancer, because the THM remains contraindicated", notes however the professor. She explains that in these cases, it is possible to "offer alternatives such as norepinephrine reuptake inhibitors and serotonin ". Antidepressants which "have an interesting effect in the management of hot flashes". For those who refuse to take antidepressants, "there are still solutions such as acupuncture, yoga, relaxation or even certain non-prescription treatments such as Acthéane or Sérélys, whose effectiveness is marginal".

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usr: 1
This is interesting!