•   
  •   
  •   

Health & Fit Here’s How the AstraZeneca COVID-19 Vaccine Compares to Pfizer’s and Moderna’s

04:40  06 january  2021
04:40  06 january  2021 Source:   prevention.com

Here’s where all the COVID-19 vaccine candidates currently stand

  Here’s where all the COVID-19 vaccine candidates currently stand More than a dozen frontrunners have reached late-stage clinical trials.Many of the other candidates, however, will fail somewhere along the vaccine development pipeline, which includes three rounds of clinical trials with increasingly large pools of volunteers to assess their safety, efficacy, and ability to prompt a response from the immune system. And for those that achieve authorization, there remain important questions that we’ll need more time and further research to answer, including how long the immunity they offer from COVID-19 lasts.

  • AstraZeneca’s COVID-19 vaccine has been approved for emergency use in the United Kingdom, India, and Mexico.
  • Unlike its competitors, AstraZeneca’s vaccine is a modified version of a common cold virus that spreads among chimpanzees.
  • This is the first vaccine of its kind to be approved for human use, but other companies are developing similar tech to fight COVID-19.

The United Kingdom became the first country to approve AstraZeneca’s COVID-19 vaccine for emergency use on Dec. 30, just weeks after Pfizer’s and Moderna’s vaccine candidates received a green light from the Food and Drug Administration in the United States. The approval is another promising sign in the global immunization rollout—especially because this option, developed by Oxford University and biopharmaceutical company AstraZeneca, could be key to reaching people in rural and underfunded areas.

Second coronavirus vaccine is 94.5% effective in clinical trial

  Second coronavirus vaccine is 94.5% effective in clinical trial US-based Moderna has got a deal to supply 100million doses to the US and potentially 160million to the European Union but the jab is not one of the six pre-ordered by British officials.Early results from the company's final stage of clinical trials bring another landmark success in the global race to end the pandemic after Pfizer's vaccine, which works the same way, was found to be 90 per cent effective. But there won't be any Moderna doses available in Europe until spring 2021, while the US will get it this year.

Unlike its competitors, the AstraZeneca COVID-19 vaccine can be stored at higher temperatures, costs less per dose, and uses different technology to immunize people. Although the vaccine hasn’t been approved for use in the U.S. yet, it could reach arms stateside in February at the earliest, The New York Times reports. Here’s what we know about the vaccine so far, and how it stacks up against Pfizer’s and Moderna’s.

How does the AstraZeneca COVID-19 vaccine work?

AstraZeneca’s vaccine uses adenovirus-vectored technology. Translation: It’s a harmless, modified version of a common cold virus that usually only spreads among chimpanzees. This altered virus can’t make you sick, but it carries a gene from the novel coronavirus’ spike protein, the portion of the virus that triggers an immune response. This allows the immune system to manufacture antibodies that work against COVID-19, teaching your body how to respond should you become infected.

How many coronavirus vaccine doses each US state will get to start

  How many coronavirus vaccine doses each US state will get to start The federal government is allocating COVID-19 vaccine doses to states according to their populations.Most states have announced how many doses they expect to receive in the first batch once a vaccine is approved.

In other words, AstraZeneca’s vaccine mimics a COVID-19 infection without its life-threatening side effects, per a release from the company. The reason researchers chose a chimpanzee adenovirus is simple: The modified virus needs to be new to the people being vaccinated—otherwise, the body won’t create those all-important antibodies. Anyone could already have antibodies for a cold spread among humans, but far fewer people have been exposed to a cold spread among chimps.

The Pfizer-BioNTech and Moderna vaccines, meanwhile, rely on mRNA technology, which essentially introduces a piece of genetic code that tricks the body into producing COVID-19 antibodies, no virus required. All three vaccines require two shots spaced about a month apart. Although no adenovirus-vectored vaccine has been approved for human use before, companies like Johnson & Johnson, CanSino, and NantKwest are all working on their own versions.

Covid-19 Vaccines: Moderna vs. Pfizer—What Docs Need You to Know

  Covid-19 Vaccines: Moderna vs. Pfizer—What Docs Need You to Know Moderna and Pfizer are the first two Covid-19 vaccines available, but how do they compare? Here are the similarities and differences to know. The post Covid-19 Vaccines: Moderna vs. Pfizer—What Docs Need You to Know appeared first on The Healthy.

How does the AstraZeneca vaccine compare to the Moderna and Pfizer vaccines?

Storage and distribution

AstraZeneca’s vaccine is the easiest to transport so far—it can be stored for up to six months between 36 and 46°F, normal refrigerator temperatures. The Moderna and Pfizer options, meanwhile, must be stored at subzero temperatures until they’re ready to be used, at -4°F and -94°F, respectively. (mRNA technology is relatively fragile compared to adenovirus-vectored tech, meaning it must be kept at much lower temperatures to remain effective and stable.)

AstraZeneca’s higher storage temperature could make distribution much easier. “A clinic, a nursing home, or even [regional] health departments may not have freezers that can hold things at -94°F,” says Kawsar Talaat, M.D., an infectious disease doctor, vaccine researcher, and assistant professor in the department of International Health at Johns Hopkins University. Being able to use a typical fridge “allows time for distribution, allows the vaccine time to get to more rural areas, [and allows vaccines] to be kept at a clinic for a longer period of time.”

Coronavirus outbreak: Live Updates

  Coronavirus outbreak: Live Updates Pandemic news from around the world.A 90-year-old woman (who will turn 91 next week) became the first in the world to be given Pfizer's coronavirus vaccine outside of clinical trials, according to the BBC. Margaret Keenan, who is originally from Northern Ireland, was given the vaccine at the University Hospital in Coventry, England. She received the first of 800,000 doses expected to be administered in the U.K. in the coming weeks, according to the BBC. "I feel so privileged to be the first person vaccinated against Covid-19," Keenan said, according to the BBC.

logo: Prevention Premium button © Hearst Owned Prevention Premium button

Cost


Gallery: This Is Which COVID Vaccine Dr. Fauci Plans to Get (Best Life)

Anthony S. Fauci wearing a suit and tie: The initial doses of Pfizer's COVID vaccine began being administered on Dec. 15 to the relief of many Americans. The Pfizer vaccine proved its safety and efficacy through various clinical trials before being approved, and now there is another noteworthy vaccine up for approval: The U.S. Food and Drug Administration (FDA) is currently reviewing the Moderna vaccine. Assuming that vaccine is approved, both the Pfizer and Moderna vaccines will soon be available to the American public. Recently, Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), shared which COVID vaccine he would be getting.While Fauci was on CNBC's Healthy Returns on Dec. 16, Meg Tirrell pointed out that Fauci and the National Institute of Health (NIH) had a

The new vaccine also beats its competitors on price: AstraZeneca’s vaccine costs providers about $4 per dose, while Pfizer’s costs $20 and Moderna’s costs $33, Al Jazeera reports. These prices will most likely fluctuate as time goes on and the vaccines evolve.

Efficacy

The two mRNA vaccines have a slight edge in efficacy; both Pfizer and Moderna report being about 95% effective against COVID-19 after the second shot in clinical trials, while AstraZeneca has reported an average efficacy of 70%, and up to 90% if the dosing is adjusted. (For comparison, the annual flu shot is usually between 40 and 60% effective, per the CDC.)

Side effects

All three vaccines’ side effects are similar, including potential injection site pain and flu-like symptoms, including fever, fatigue, headaches, and muscle pain, which are to be expected as your immune system is primed.

Which COVID-19 vaccine is the best?

There’s no “best” vaccine option, as there’s not enough research to confirm that yet. Vaccines aren’t a silver bullet, especially as the pandemic rages on: They must be combined with masks, hand-washing, and social distancing to work as effectively as possible, per the CDC. No matter which COVID-19 vaccine becomes available to you first, you can feel confident in its ability to protect you, as long as you continue being cautious until positive cases, hospitalizations, and deaths are significantly reduced nationwide.

15 surprising risks associated with lack of sleep

  15 surprising risks associated with lack of sleep You probably already know that not getting enough sleep isn’t great for your health. But what exactly are the risks of not allowing your body the time it needs to fully recharge? Read on to find out.

In the meantime, it’s likely “that all the manufacturers are working on making their vaccines more stable at easier-to-manage temperatures,” Dr. Talaat explains. As their formulations change, their pros and cons will, too.

For now, we can be thankful that AstraZeneca’s vaccine is nearing worldwide clearance. “The next generation of vaccines, like AstraZeneca’s, which is kept at refrigerator temperatures, is a major advancement,” Dr. Talaat says. “When you’re talking about distribution to the entire world, it’s much easier to do because we already keep vaccines cold. It’s a lot harder to keep things frozen.”

Go here to join Prevention Premium (our best value, all-access plan), subscribe to the magazine, or get digital-only access.

FOLLOW PREVENTION ON INSTAGRAM

Try 200+ at home workout videos from Men’s Health, Women’s Health, Prevention, and more on All Out Studio free for 14 days!

50 Foods You Should Stop Eating Right Now .
What foods should you never eat again?

usr: 0
This is interesting!