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Health & Fit Humans Could Live to Be 150, Science Says

11:10  02 august  2021
11:10  02 august  2021 Source:   prevention.com

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Scientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives . Researchers have now taken on the question of how long we can live if, by some combination of serendipity and genetics, we do not die from cancer, heart disease or getting hit by a bus. They report that when omitting things that usually kill us, our body’s capacity to restore equilibrium to its myriad structural and metabolic systems after disruptions still fades with time.

New research says humans can live up to 150 years old. But is there a hard limit to life expectancy? But the thing that's keeping the human body from reaching immortality is surprisingly mundane: over time, your body loses the "physiological resilience," or the ability to bounce back, that you once had in your younger years. That, scientists say in a study published earlier this year in Nature Communications, is enough to limit our lives to 120 to 150 years at the most.

a large clock mounted to the side: New research says humans can live up to 150 years old. But is there a hard limit to life expectancy? © PM Images New research says humans can live up to 150 years old. But is there a hard limit to life expectancy?
  • New research indicates the hard limit on human life is 150 years.
  • The main factor limiting our lifespan is a loss of the ability to bounce back after a setback, called "physiological resilience."
  • Even without major health issues, like cancer, your body will eventually run out of energy to help recover from even minor challenges.

Even if you somehow manage to make it through decades of old age without a single major health issue—evading cancer, heart disease, diabetes, and so on—scientists say there's a ceiling on how long you can extend your life, throwing cold water on the ambitious Silicon Valley goal to outsmart death.

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Human beings have a maximum lifespan, and it’s probably 115 years, researchers said Wednesday. While life expectancy continues to increase — that’s a measure of how long any individual can expect to live — maximum lifespan has not, the team at the Einstein College of He calculates that one in 5 million people lives to be 110 or older. He thinks there is something different about them. It’s easy to get to be old, Perls says . “That is what the Seventh Day Adventist health study has shown us,” he said . “If you take advantage of this average set of genes that we have — you don’t smoke, you don’t drink

A new study finds you might want to think about it because it’s possible for humans to live to see their 150 th birthday! Scientists in Singapore have developed an iPhone app that accurately estimates biological aging. It discovered that life expectancy has the capacity to be almost double the current norm. “Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration,” says Gero co-founder Dr. Peter Fedichev. “This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different aspects of

But the thing that's keeping the human body from reaching immortality is surprisingly mundane: over time, your body loses the "physiological resilience," or the ability to bounce back, that you once had in your younger years. That, scientists say in a study published earlier this year in Nature Communications, is enough to limit our lives to 120 to 150 years at the most.

Lead researcher Timothy Pyrkov is part of a Singapore-based biotech company called Gero (yes, the name itself is the prefix meaning "old age"). Gero's stated goal is "hacking complex diseases and aging," setting a clear agenda for the research. For this longitudinal analysis, Gero collaborated with Roswell Park Comprehensive Cancer Center in Buffalo, New York and studied large groups of people in the U.S., U.K., and Russia.

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A new study suggests that the maximum life span for human beings is around 120 to 150 years. Your accounts lets you Digg (upvote) stories, save stories to revisit later, and more. Stay up-to-date. Email will be sent to: Select the newsletters you’d like to receive. You can change your subscriptions any time in your user settings.

"Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration,” said Peter Fedichev, co-founder and CEO of Gero, a biotech company involved in the research. “This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different “It explains why even most effective prevention and treatment of age-related diseases could only improve the average but not the maximal lifespan unless true anti-aging therapies have been developed,” Gudkov concluded. The oldest human on record lived to be 122.

The team broke down all the age groups in detail, differentiating between "early adulthood" (16- to 35-year-olds), "middle ages" (35- to 65-year-olds), and "older ages" (older than 65). Then, they examined both changes in blood cell counts and the number of steps the groups took, treating the two factors as "hallmarks of aging" that could help them chart the subjects' progress (or deterioration) over several months.

Both blood cells and steps might remain constant, the researchers found, if not for periodic interruptions in the form of health setbacks. Specifically, they noticed the problem wasn't some steady decline with age, but instead, a series of step-downs in which the subjects' bodies could not return to their previous level of health.

chart: Despite the two variables being so different, blood cell counts and steps each decreased at a similar rate in the test subjects over time. © Nature Communications Despite the two variables being so different, blood cell counts and steps each decreased at a similar rate in the test subjects over time.

Let's say when you're younger, your body could normally recover 100 percent from a bad cold, or repair your skin 100 percent of the way after a bad fall. As you age, your ability to claw back to full health may be inhibited to a max of, say, 95 percent. And with more time, that resiliency will only continue to decrease as your body faces repeated obstacles. Basically, it's the opposite of gaining more health in a video game as you progress further—your stamina bar becomes smaller and smaller, even when it's full.

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We live in unprecedented times and the pace of change and innovation is explosive. Unlike any other era, mankind has the means to destroy the world completely and in so many ways. If mankind does not succumb to man-made or natural disasters, and continues to progress exponentially, it becomes Mankind’s curiosity has taken us to the stage when we can start to answer some of the fundamental questions about ourselves, why we are here and what are the mechanisms that got us to this point. I believe that we stand on the threshold where this understanding can be translated into the most

In actuality, we can definitely live 200 and even 300 years, but most people’ brains have never been given an objective to live that long. You know, common sense is a heavy factor to be neglected. I think people could live at least to 150 years but possibly also to 200 years but for that to happen a lot has to change. We live in societies that look down on people once they reach their seventies and beyond. Most old people are preyed up mercilessly by inhumane people, most of which are relatives.

By plotting the "recovery time" for all three age group cohorts over decades' worth of life, the researchers were able to find the point at which the body would ultimately disintegrate as a result of the loss of resiliency. Every year, for example, think of the risk of cancer as a kind of coin toss with a certain likelihood of happening. The longer you live, the more coin flips you must take. The point at which you take that last coin flip, they say, is somewhere between 120 and 150 years—a value that likely puts a hard limit on human life.

"We conclude that the criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan," the authors note in the paper.

Why study those two variables? Blood cell counts, for their part, have a predictable healthy range that is dependent on your age and gender. Generally speaking, the normal range for red blood cells is between 4.5 to 5.5 million cells per cubic millimeter if you're male, and between 4 to 5 million cells per cubic millimeter if you're female, according to the University of Pittsburgh Medical Center. For white blood cells, the normal range is between 5,000 and 10,000 cells per cubic millimeter. For platelets, the typical range is 140,000 to 400,000 per cubic millimeter.

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Deviations from these ranges could signal some kind of disorder. A low red blood cell count, for example, could point to anemia, while a low white blood cell count could mean you have neutropenia, a disease that damages the bone barrow at puts you at increased risk for infections.

Steps taken is a far murkier variable, though, as it's somewhat subjective. The general consensus, and the recommendation from the U.S. Centers for Disease Control and Prevention (CDC), is to aim for 10,000 steps per day. Still, that's highly personal, and the number of steps that a person needs to take to achieve positive health impacts actually declines with age: A 2019 study published in the journal JAMA Internal Medicine showed the more steps a person took, the lower their mortality rate, but the effect leveled off after 7,500 steps per day.

The differences between these two variables make the team's results more interesting. Peter Fedichev—one of the study's coauthors, and a cofounder of Gero—told Scientific American that despite how most biologists would see blood counts and step counts as "pretty different," the sheer fact that both "paint exactly the same future" means the steady decline of physiological resilience is very real.

So, what does it mean to have a hard limit on human life? Without intervention in the form of body part replacements or other supplemental procedures, it means even the most zealous life-extenders can only do so much. And while 120 to 150 years may not sound super long, it's still up to nearly twice the life expectancy of people living today in the U.S.

And considering the late Jeanne Louise Calment—who holds the record for the longest-living person—died at the age of 122 years and 164 days, it seems like they're onto something.

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