Politics Large Study Finds No Benefit — and Potential Harm — in Using Hydroxychloroquine for COVID-19

01:07  23 may  2020
01:07  23 may  2020 Source:   time.com

Trump’s claim he takes hydroxychloroquine prompts criticism from media, health experts

  Trump’s claim he takes hydroxychloroquine prompts criticism from media, health experts President Trump stoked a flurry of comments Monday after revealing to reporters that he has been taking hydroxychloroquine, a controversial malaria drug, to stave off the novel coronavirus.  Trump said he has been taking hydroxychloroquine and a zinc supplement daily "for about a week and a half now." require(["medianetNativeAdOnArticle"], function (medianetNativeAdOnArticle) { medianetNativeAdOnArticle.getMedianetNativeAds(true); }); Trump has spent weeks pushing the drug as a potential cure for COVID-19, despite there being no consensus on its effectiveness or safety.

"In this study , we found no evidence that use of hydroxychloroquine , either with or without azithromycin, reduced the risk of mechanical ventilation in patients hospitalized Trump has touted the drug as a "game changer" for Covid - 19 and said hydroxychloroquine shows "tremendous promise."

Hydroxychloroquine found to harm COVID - 19 patients. Another big study finds no benefit for COVID - 19 patients. Hydroxychloroquine does not help COVID - 19 patients, and indeed may increase deaths, according to a large , international study published Friday in The Lancet.

In the largest observational study thus far investigating the drug hydroxychloroquine as a treatment for COVID-19, researchers found little evidence that it helps, and worrying evidence that the medication may cause harm.

a close up of a bottle: A bottle and pills of Hydroxychloroquine sit on a counter at Rock Canyon Pharmacy in Provo, Utah, on May 20, 2020. © George Frey — AFP/Getty Images A bottle and pills of Hydroxychloroquine sit on a counter at Rock Canyon Pharmacy in Provo, Utah, on May 20, 2020.

In a study published May 22 in the journal Lancet, scientists in the U.S. and Switzerland report on an analysis of more than 96,000 people hospitalized with confirmed COVID-19 in 671 hospitals on six continents. Nearly 15,000 patients were treated with one of the following: chloroquine (which is an older version of hydroxychloroquine), hydroxychloroquine, or either of those drugs in combination with an antibiotic. The remainder did not receive any of these medications and served as the control.

Nancy Pelosi calls Trump 'morbidly obese' and says it's not a good idea for him to take hydroxychloroquine

  Nancy Pelosi calls Trump 'morbidly obese' and says it's not a good idea for him to take hydroxychloroquine Trump appeared to fully back hydroxychloroquine, despite it not being endorsed by health officials."He's our president and I would rather he not be taking something that has not been approved by the scientists, especially in his age group and his, shall we say, weight group," Pelosi said during an interview with CNN host Anderson Cooper on Monday.

Hydroxychloroquine is being studied to determine if it can prevent the onset of Covid - 19 before or after a patient is infected with the SARS coronavirus It is thus considered a recommended antiviral for Covid - 19 treatment in China, and several countries are recommending both drugs for hospitalized

"This provides evidence that hydroxychloroquine does not apparently treat patients with Covid 19 The study also raised important safety concerns about hydroxychloroquine . In the study , eight Abnormal heart rhythms are a known side effect of hydroxychloroquine , which has been used for

People in any of the four treatment groups were more likely to die during their hospitalization than those not treated. People receiving either chloroquine or hydroxychloroquine alone were 16% to 18% more likely to die in the hospital compared to those not receiving the medications, and those treated with these medications in combination with an antibiotic were 22% to 24% more likely to die in the hospital. These risks remained significant even after the researchers controlled for factors such as smoking, underlying heart disease, diabetes, lung disease, or immune conditions.

Trump trumpets that he is taking chloroquine, in violation of health recommendations

 Trump trumpets that he is taking chloroquine, in violation of health recommendations Your browser does not support this video The President of the United States has been defending hydroxychloroquine, an antimalarial treatment acclaimed in France by the doctor for several weeks Raoult, and this while recent studies have concluded that there is no effect against Covid-19. © Copyright 2020, L'Obs He has been taking "one tablet a day" for "a week and a half".

A new study -- the largest of its kind -- shows that hydroxychloroquine Study finds no benefit , higher death rate in patients taking hydroxychloroquine for Covid - 19 . "I'd be surprised if there were many patients and their families or doctors who would want to pursue using hydroxychloroquine ."

Hydroxychloroquine and chloroquine didn’t benefit patients with the coronavirus, either alone or in combination with an antibiotic, according to the study published The drugs should only be used for Covid treatment as part of robust studies that will definitively show their impact, the researchers said.

In addition, those receiving the medications had higher risk of developing abnormal heart rhythms — a known risk factor of chloroquine and hydroxychloroquine — compared to people who were not treated with the medications.

“However we sliced and diced the data, the results were identical,” says Dr. Mandeep Mehra, chair of cardiovascular medicine at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, who led the study. “There was no evidence of benefit, and a consistent signal of harm — and in particular, harm linked to heart rhythm disturbances.”

The findings come as U.S. President Donald Trump claimed to be taking hydroxychloroquine, which he requested from the White House physician, because he “heard a lot of good stories.” Mehra notes that the study included only people diagnosed with COVID-19, while the President has not been reported to be infected.

Trump, after coronavirus test, says 'I tested positively toward negative'

  Trump, after coronavirus test, says 'I tested positively toward negative' President Trump on Thursday disclose the results of his daily coronavirus test by saying he “tested positively toward negative.” "I tested very positively in another sense. I tested positively toward negative,” Trump told reporters. “I tested perfectly this morning, meaning I tested negative.” © Provided by FOX News Trump announced on May 7 that he, Vice President Pence and other senior officials would begin receiving daily coronavirus tests after a member of the president's valet tested positive for the virus, which has infected 1.5 million Americans and killed more than 93,000.

Two large observational studies , each involving around 1,400 patients in New York, recently found no COVID benefit from hydroxychloroquine . No large , rigorous studies have found the drug safe or effective for preventing or treating COVID - 19 . Trump said he decided to take hydroxychloroquine

Under study for COVID - 19 . Hydroxychloroquine and a related drug, chloroquine, are currently under study as possible treatments for COVID - 19 . This damage is more likely when the drug is used in high doses. This drug should only be used during pregnancy if the potential benefit justifies the potential risk.

Hydroxychloroquine is approved to treat malaria — replacing chloroquine in many parts of the world after the malaria parasite became resistant to chloroquine — as well as some autoimmune disorders like rheumatoid arthritis and lupus, because of its ability to tamp down inflammation. Doctors started to turn to the drug to treat COVID-19 after a small study in France suggested it might help alleviate some of the disease’s inflammatory symptoms, which can compromise breathing and cause respiratory failure. The evidence for the drug’s effectiveness, however, hasn’t been established, although ongoing rigorous trials randomly assigning patients to receive hydroxychloroquine or placebo are still ongoing (including one headed by the U.S. National Institutes of Health).

But there is growing evidence that the medication may not be as helpful as doctors had hoped. In a study of more than 1,300 people admitted to New York Presbyterian-Columbia University Irving Medical Center, for example, people receiving hydroxychloroquine did not show any lower rate of needing ventilators, or a lower risk of dying during the study period than those not getting the drug. Studies from Europe and China similarly failed to find that the drug showed any benefit for patients.

Hydroxychloroquine: Olivier Véran requests a revision of the prescription rules

 Hydroxychloroquine: Olivier Véran requests a revision of the prescription rules © Copyright 2020, L'Obs The Minister of Health Olivier Véran asked the High Council for Public Health (HCSP) on Saturday to propose "within 48 hours a review of the derogatory prescription rules ”for various treatments such as hydroxychloroquine, after the publication of a study showing its ineffectiveness and risks for Covid-19 patients.

A study performed in New York hospitals found no evidence of either harm or benefit from giving the malaria drug hydroxychloroquine to severely ill US regulators last week authorized the emergency use of the experimental drug remdesivir against COVID - 19 after it was shown in a major clinical trial

A widely publicized study in France where 40 coronavirus patients were given hydroxychloroquine , with more than half experiencing the clearing of their airways within three to six days has led to it being touted in some quarters as a potential cure for Covid - 19 . This apparent improvement is important as

Those studies have led the U.S. Food and Drug Administration (FDA) to warn health providers that they should not prescribe hydroxychloroquine off-label for COVID-19 patients unless they are part of a research study or carefully monitored in a hospital setting.

In fact, as the evidence continues to suggest that hydroxychloroquine may not provide much benefit, and instead might increase the risk of harm to the heart, Mehra says doctors may shift from considering hydroxychloroquine to other drugs being studied as COVID-19 treatments, like remdesivir. Studies indicate that remdesivir, an antiviral that has not yet been approved to treat any disease, may help people with COVID-19 to recover faster, and the drug received FDA emergency use authorization to treat hospitalized patients. Unlike hydroxychloroquine, remdesivir has not been linked to serious side effects so far, and therefore may be a more attractive option for doctors treating COVID-19 patients.

“They may be more likely to try something where there is a better chance of showing a net positive outcome,” says Mehra. “Why would you risk harm when there is so much consistent data showing lack of benefit [with hydroxychloroquine]?”

Covid-19: what the French health authorities say about hydroxychloroquine .
This drug promoted by Didier Raoult will soon no longer be able to be administered in France, either to seriously ill patients or during clinical trials, after two opinions. © afp.com/GERARD JULIEN Hydroxychloroquine, promoted by Professor Didier Raoult, has been widely used, without formal proof of its effectiveness.

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