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Sport Cyrus Biotechnology and CRISPR pioneers team up to boost gene-editing therapies

02:55  03 december  2019
02:55  03 december  2019 Source:   msn.com

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CRISPR gene editing is a method by which the genomes of living organisms may be edited. It is based on a simplified version of the bacterial CRISPR /Cas ( CRISPR -Cas9) antiviral defense system.

Since the gene editing technology first entered the spotlight in 2012 with the promise of revolutionizing gene editing , it has made headlines as the subject of a Up until now, TALEN has been the standard method, but will CRISPR take over? We asked VP David Sourdive of Cellectis, one of the European

Seattle-based Cyrus Biotechnology says it’ll collaborate with the Broad Institute of MIT and Harvard on ways to optimize CRISPR gene-editing techniques for use in developing novel human therapeutics.

Feng Zhang standing in front of a refrigerator: MIT researcher Feng Zhang will be the principal investigator for the Broad Institute’s collaboration with Cyrus Biotechnology. (HHMI Photo)© Provided by Geekwire MIT researcher Feng Zhang will be the principal investigator for the Broad Institute’s collaboration with Cyrus Biotechnology. (HHMI Photo)
  • CRISPR has revolutionized genetics by making it easier to modify the DNA coding in the genome, but more needs to be done to address safety concerns for human applications. Cyrus Biotech and the Broad Institute will work on ways to reduce the potential for the body to mount an immune response against CRISPR-based therapies.
  • MIT biochemist Feng Zhang, one of the pioneers in the development of CRISPR, will be the principal investigator for the effort at the Broad Institute. The results of the collaboration will be published in peer-reviewed journals and made freely available to the academic and non-profit scientific community.
  • Privately held Cyrus Biotech offers software and partnerships to accelerate the discovery of engineered proteins, primarily for therapeutic applications. Its software tools are derived from the Rosetta protein-modeling platform, which was developed at the University of Washington.

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