•   
  •   
  •   

US J&J scientists refute 'class effect' to blame for clots in those who got its COVID-19 vaccine

22:35  16 april  2021
22:35  16 april  2021 Source:   reuters.com

Food banks, passing on passports, governors’ shots: News from around our 50 states

  Food banks, passing on passports, governors’ shots: News from around our 50 states How the COVID-19 pandemic is affecting every stateStart the day smarter. Get all the news you need in your inbox each morning.

By Julie Steenhuysen

a group of people sitting in chairs: FILE PHOTO: A woman receives a dose of the Johnson & Johnson coronavirus disease (COVID-19) vaccine at vaccination center in Chinatown, in Chicago © Reuters/CARLOS BARRIA FILE PHOTO: A woman receives a dose of the Johnson & Johnson coronavirus disease (COVID-19) vaccine at vaccination center in Chinatown, in Chicago

CHICAGO (Reuters) - Scientists at Johnson & Johnson on Friday refuted an assertion in a major medical journal that the adenovirus-based design of their COVID-19 vaccine, which is similar AstraZeneca's, may explain why both have been linked to very rare brain blood clots in some vaccine recipients.

The United States earlier this week paused distribution of the J&J vaccine to investigate six cases of a rare brain blood clot known as cerebral venous sinus thrombosis (CVST), accompanied by a low blood platelet count, in U.S. women under age 50, out of about 7 million people who got the shot.

Immigrant aid, lifeguard shortage, Frontier Days: News from around our 50 states

  Immigrant aid, lifeguard shortage, Frontier Days: News from around our 50 states How the COVID-19 pandemic is affecting every stateStart the day smarter. Get all the news you need in your inbox each morning.

The blood clots in patients who received the J&J vaccine bear close resemblance to 169 cases in Europe reported with the AstraZeneca vaccine, out of 34 million doses administered there.

Both vaccines are based on a new technology that uses modified versions of adenoviruses, which can cause respiratory and gastric illnesses, as vectors to ferry instructions to human cells. Several scientists have suggested the issue may be a "class effect" linked to this type of vaccine.

In a letter on Friday in the New England Journal of Medicine, J&J scientists refuted a case report published earlier this week in the NEJM by Kate Lynn-Muir and colleagues at the University of Nebraska, who asserted that the rare blood clots "could be related to adenoviral vector vaccines." (https://bit.ly/3doTsYH)

Ramadan rules, Flags of Hope, zoo overnights: News from around our 50 states

  Ramadan rules, Flags of Hope, zoo overnights: News from around our 50 states How the COVID-19 pandemic is affecting every stateStart the day smarter. Get all the news you need in your inbox each morning.

In an interview with Reuters on Thursday, Dr. Anthony Fauci, the top U.S. infectious disease expert and an adviser to the White House, said the fact that they are both adenovirus vector vaccines is a "pretty obvious clue" that the cases could be linked to the vector.

"Whether that is the reason, I can't say for sure, but it certainly is something that raises suspicion," Fauci said.

In the correspondence on Friday, Macaya Douoguih, a scientist with J&J's Janssen vaccines division, and colleagues pointed out that the vectors used in its vaccine and the AstraZeneca shot are "substantially different" and that those differences could lead to "quite different biological effects."

Specifically, they noted that the J&J vaccine uses a human adenovirus while the AstraZeneca vaccine uses a chimpanzee adenovirus. The vectors are also from different virologic families or species, and use different cell receptors to enter cells.

What to Do if You Have an Appointment for the Johnson & Johnson COVID Vaccine

  What to Do if You Have an Appointment for the Johnson & Johnson COVID Vaccine Those who have already made appointments for the J&J vaccine should consider rescheduling options that may be available to them. © Michael M. Santiago/Getty Images A dose of the Johnson & Johnson coronavirus (COVID-19) vaccine is seen on a table at the Northwell Health pop-up coronavirus (COVID-19) vaccination site at the Albanian Islamic Cultural Center in Staten Island on April 08, 2021 in New York City. NYC continues to have a 6.55 percent coronavirus (COVID-19) cases on a seven-day rolling average as the city continues to ramp up vaccinations.

The J&J shot also includes mutations to stabilize the so-called spike protein portion of the coronavirus that the vaccine uses to produce an immune response, while the AstraZeneca vaccine does not.

"The vectors are very different," said Dr. Dan Barouch of the Center for Virology and Vaccine Research at Harvard's Beth Israel Deaconness Medical Center in Boston, who helped design the J&J vaccine.

"The implications of issues with one vector for the other one are not clear at this point," he said in an interview earlier this week.

The J&J scientists said in the letter there was not enough evidence to say their vaccine caused the blood clots and they continue to work with health authorities to assess the data.

A panel of advisers to the U.S. Centers for Disease Control and Prevention are expected to meet on April 23 to determine whether the pause on use of the J&J vaccine can be lifted.

SOURCE: https://bit.ly/2P0TLQc The New England Journal of Medicine, online April 16, 2021.

Scientists exploring possible link between J&J, AstraZeneca vaccine blood clot issues .
Similarities between Johnson & Johnson and AstraZeneca blood clot issues have scientists exploring possible linkDoctors, scientists and public health experts are turning to Europe for clues, where a similar vaccine made by AstraZeneca -- not yet authorized in the U.S. -- also has been linked to a number of rare blood clots.

usr: 0
This is interesting!