World Russian vaccine Sputnik V more than 90% effective in interim trial
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The Russian coronavirus vaccine, Sputnik V, was 92 percent effective at preventing symptomatic illness in a large clinical trial, robust protection that puts it in line with top vaccines developed in the United States and Europe, according to results published in a peer-reviewed journal Tuesday.
Thehas been criticized for being too rushed, elevating over scientific evidence. The publication in , a British medical journal, marks the first large-scale, peer-reviewed results to be published showing the performance of Sputnik V — despite the fact that the vaccine has been in and is being rolled out to .
A top Russian diplomat was caught secretly getting the Pfizer COVID-19 vaccine, shunning his country's prized Sputnik V
Russia has not approved a COVID-19 vaccine other than its own Sputnik V. Yuri Gribkov got his Pfizer shot in Estonia.Yuri Gribkov, who is Russia's consul general to Estonia, was confronted by a reporter from the Estonian news outlet Delfi on Wednesday as he left a hospital in Ida-Viru, an Estonian town located 32 miles from the Russian border.
Outside experts said the data convincingly shows the vaccine works. But because the trial was conducted in Russia in the fall, before the spread ofthat have shown signs of eroding vaccine effectiveness, questions loom about how protective the vaccine will be in the face of emerging threats.
“Results are great,” Hildegund C.J. Ertl, a vaccine scientist at the Wistar Institute, said in an email. “Good safety profile, more than 90% efficacy across all age groups, 100% efficacy against severe disease or death, can be stored in the fridge and low cost. What more would we want?”
Kirill Dmitriev, chief of the Russian Direct Investment Fund, a state fund that had backed the vaccine, said the results proved that criticism of the vaccine was unfounded.
If your loved one is hesitant to get the Covid-19 vaccine, share this
To answer questions you or your loved ones may have about the Covid-19 vaccine, we consulted with two experts. The evidence supports the safety and efficacy of the two Covid-19 vaccines currently authorized.But vaccine hesitancy could put a dangerous damper on the country's Covid-19 response. Pockets of some populations most at risk of severe sickness from Covid-19, including young nurses and Black Americans, are still dubious of the vaccine -- because of the speed at which it was developed, its contents and potential side effects.
“All our critics are keeping quiet at the moment because they are running out of arguments. We have addressed all of their concerns. Sputnik V has proven itself to be one of the most effective and safest vaccines in the world,” he said at a news conference.
The news was also a relief to foreign officials who had been relying on the Russian-made vaccine to fill gaps left in their supplies. Mexico’s deputy health minister, Hugo López-Gatell, had flown to Argentina last month to follow the country’s Phase 3 testing of Sputnik V. López-Gatell said Tuesday the public had felt “a concern, a worry that is totally legitimate about whether the [Russian] vaccine is effective.”
He said he hoped the results published in the Lancet put those anxieties to rest.
“This gives us an enormous opportunity to accelerate the pace of vaccination against covid in Mexico,” he said. Mexican authorities are expected to formally approve emergency use of the Russian vaccine Tuesday.
Covid-19: the effectiveness of the Russian Sputnik V vaccine confirmed by The Lancet
© Juan Mabromata, AFP The Russian Sputnik V vaccine is 91.6% effective against Covid-19, according to the medical journal The Lancet. The Sputnik V vaccine, about which Russia had been accused of lacking transparency, is 91.6% effective against symptomatic forms of Covid-19, according to results published Tuesday in the medical journal The Lancet and validated by independent experts.
Almost 20,000 participants took part in the Phase 3 trial, with roughly three-quarters receiving the vaccine, while the remainder received a placebo.
The results appear to make Sputnik V the third coronavirus vaccine to have an efficacy of more than 90 percent, along with the Pfizer-BioNTech and Moderna vaccines. But experts have repeatedly cautioned that it can be misleading to compare performance in different vaccine trials, because of differences in how the trials are designed and when and where they were conducted.
Vaccines that have been tested more recently, in areas of the world where variants have become dominant, such as vaccine candidates fromand , appear less efficacious against a form of the virus that is rapidly becoming dominant.
Peter Jay Hotez, a vaccine scientist at Baylor College of Medicine, said he was concerned that antibody levels sparked by the Russian vaccine appeared relatively modest. While the vaccine may have offered robust protection against the form of the virus circulating in Russia in September and November, laboratory tests have demonstrated that antibodies triggered by other vaccines are less effective against the variants, particularly one that originated in South Africa and is rapidly spreading globally.
Some good news from Britain on vaccines and transmission
The Covid-19 vaccine developed by the University of Oxford and AstraZeneca not only prevents people from developing symptomatic coronavirus infections, but also appears to slow down transmission of the coronavirus, researchers reported on Tuesday. © Reuters CDC releases illustration of the Coronavirus. The findings, released in a preprint paper that has not yet been peer reviewed, are the first evidence that a Covid-19 vaccine can reduce the virus' spread, and underlines the importance of mass vaccination as a way out of the pandemic.
“The worry is that when you’re starting out low like this … as the South African variant comes through, this [vaccine] may no longer protect,” Hotez said. “I think that’s what’s probably going to happen, and the Russians are going to look at recasting this vaccine in some way.”
In the trial, participants who received Sputnik V were administered two shots 21 days apart. The regimen uses two different harmless cold viruses, called adenoviruses, to infect cells with a gene that carries the blueprint for the spike protein found on the surface of the coronavirus. By using two different viruses to deliver the gene, the vaccine regimen avoids one possible problem with such an approach — that the body may build an immune response to the cold virus that delivers the gene, blocking the booster shot’s ability to rev up the immune system.
The technology is similar to that used by the single-shot Johnson & Johnson vaccine, which reported 66 percent efficacy overall at preventing moderate and severe disease four weeks after the shot, and the vaccine developed by AstraZeneca and Oxford University, which E.U. regulators have judged to be about 60 percent effective., the Russian research institute that developed Sputnik V, announced in December that they are working together to explore whether combinations of their vaccines might be beneficial.
As Europe’s vaccination efforts falter, Russia and China are now seen as options
Russia is seeking a Sputnik V partner in Germany. China is considering a bid for E.U. approval. Vaccines produced in Russia and China are already on the program in parts of the Balkans and Eastern Europe outside the E.U. Now, French President Emmanuel Macron and German Chancellor Angela Merkel have expressed their openness to using offerings from Moscow and Beijing if E.U. regulatory approval is granted.
The Russian vaccine, like those others, appeared to be most effective at preventing serious cases of disease. In the Johnson & Johnson trial, there were no cases of hospitalization or death related to covid-19, the illness caused by the virus, in people receiving the vaccine. In the Russian trial, there were no cases of moderate or severe covid-19 cases among vaccinated people, while there were 20 cases among those who received placebo. In the AstraZeneca-Oxford trial, there were 10 covid-19-related hospitalizations, all among people who received placebo.
“The vaccine appears to induce decent protection, consistent with their previous press releases,” said Konstantin Chumakov, a member of the Global Virus Network, an international coalition working on viral threats. “It confirms the expectations that adenovirus-based vaccines can be effective, at least in the short run. Now, it remains to be seen how long the immunity will last, and whether it will protect against the variant strains.”
There were 62 confirmed cases of covid-19 in the placebo group, compared with 16 infected people found in the vaccine group, none of whom had severe symptoms.
The trial included more than 2,000 volunteers who were older than 60. Results did not differ statistically for this older group.
There were limited side effects in those who received Sputnik V, the developers said, with 94 percent of adverse effects described as mild, including flu-like symptoms and reactions at the injection site.
After receiving approval Aug. 11 in Russia, the vaccine’s developers marketed Sputnik V aggressively, setting up a website that dubbed the vaccine the “″ and to not only promote it but cast doubt upon rivals.
Sputnik V’s developers say the vaccine is already registered in 12 countries. It remains the only vaccine to be used in a low-income country, after being used on a.
Mary Beth Sheridan in Mexico City contributed to this report.
Iran to Start Covid-19 Vaccinations Using Russia’s Sputnik V Jab .
(Bloomberg) -- Iran will start its first coronavirus vaccinations this week using Russia’s Sputnik V shot to inoculate health care workers at the epicenter of the Middle East’s worst outbreak, the state-run Islamic Republic News Agency reported. The shots will be given to medical personnel who have been tending to serious cases of the disease in intensive care units from Feb. 9, Iran’s Health Minister Saeed Namaki said on Sunday, without giving more details, according to IRNA.Iran has the Middle East’s worst coronavirus outbreak with more than 1.4 million cases and almost 60,000 deaths reported so far. Officials have blamed U.S.